OCT4 Antibody 0.1 ml Embryonic Stem Cell Marker

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Western Blot: OCT4 Antibody [NB100-2379] - Detection of OCT4 in mouse brain lysate.
Immunocytochemistry/Immunofluorescence: OCT4 Antibody [NB100-2379] - OCT4 staining in NTERA-2 cells detected with a Dylight 488 labeled secondary antibody.
Flow Cytometry: OCT4 Antibody [NB100-2379] - Staining of NTERA-2  cells using NB100-2379 at a 1:50 dilution detected using Dylight-488 conjugated goat anti-rabbit secondary antibody.
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Ordering Information: NB100-2379

  • Catalog Number
    NB100-2379
  • Displayed Format
    Unconjugated
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OCT4 Antibody Summary

Species Human, Mouse, Rat, Primate
Predicted Species
Feline (93%), Porcine (93%), Bovine (93%). Backed by our 100% Guarantee
Tested Applications WB, FLOW, ICC/IF
Clonality
Polyclonal
Host
Rabbit
Gene
POU5F1
Purity
Immunogen affinity purified
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OCT4 Antibody Details

Marker
Embryonic Stem Cell Marker
Immunogen
A synthetic peptide made to an internal portion of the human OCT4 protein (between residues 100-200) [UniProt# Q01860]
Localization
Nuclear

Species Reactivity

Human, monkey, rat, mouse. Immunogen has 93% homology to cow, feline and pig. Customer feedback suggests that this antibody does not give good results in IHC-P on feline tissues.
Publications Read Publications using NB100-2379 in the following species:


Applications/Dilutions

Dilutions
  • Western Blot 2ug/ml
  • Flow Cytometry 1:50-1:200
  • Immunocytochemistry/Immunofluorescence 1:50-1:200
Application Notes
This OCT4 antibody is useful for Immunocytochemistry/Immunofluorescence, Flow Cytometry, and Western blot where a band is seen at ~40 kDa.
Molecular Weight
40 kDa
Positive Controls
Other Available
Formats
Alexa Fluor (R) 405 Labeled NB100-2379AF405
Alexa Fluor (R) 488 Labeled NB100-2379AF488
Alexa Fluor (R) 647 Labeled NB100-2379AF647
Alexa Fluor (R) 700 Labeled NB100-2379AF700
Biotin Labeled NB100-2379B
DyLight 405 Labeled NB100-2379V
DyLight 488 Labeled NB100-2379G
DyLight 550 Labeled NB100-2379R
DyLight 650 Labeled NB100-2379C
FITC Labeled NB100-2379F
HRP Labeled NB100-2379H
PE Labeled NB100-2379PE
Control Peptide
OCT4 Peptide (NB100-2379PEP)
Publications
Read Publications using
NB100-2379 in the following applications:

Contact Information

Product PDFs

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Reviews

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Publications

OCT4 Antibody (NB100-2379) has been mentioned in at least 4 publications.
Earn rewards if you have published using OCT4 Antibody (NB100-2379).

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
Tris-glycine, 150 mM NaCl
Unit Size
0.1 ml
Concentration
0.85 mg/ml
Preservative
0.05% Sodium Azide
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

Gene Symbol POU5F1
Entrez
Uniprot

Alternate Names for OCT4 Antibody

  • class 5, transcription factor 1
  • MGC22487
  • Oct-3
  • OCT3Oct4
  • Oct-4
  • Octamer-binding protein 3
  • OTF3POU domain class 5, transcription factor 1
  • OTF4
  • POU class 5 homeobox 1
  • POU-type homeodomain-containing DNA-binding protein
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Related Products by Gene

Background

OCT4 (octamer-binding protein 4) is a transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and generates a trimeric complex with SOX2 on DNA for controlling the expression of several genes (YES1, FGF4, UTF1, ZFP206 etc.) involved in embryonic development. Expressed mainly in the nucleus, OCT4 interacts with UBE2I, ZSCAN10, PKM, WWP2 etc. and OCT4-PKM interaction positively regulate OCT4's transcriptional activity. Once translated, its modifications such as sumoylation enhances the protein stability, DNA binding and transactivation activity and is required for enhanced YES1 expression. OCT4 undergoes 'Lys-63'-linked polyubiquitination by WWP2 leading to proteasomal degradation. OCT4 is found in oocytes and is zygotically expressed in pluripotent cells of pre-gastrulation embryos, and has been observed to be essential for early embryogenesis as well as for embryonic stem cell pluripotency. OCT4 is expressed in developing brain with highest levels in specific cell layers of the cortex, the olfactory bulb, hippocampus and cerebellum. Its expression decreases gradually after embryoid body formation, however, improper re-activation of OCT4 contributes to oncogenic processes and it has been implicated in certain malignancies such as breast and ovarian cancer.

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Publications for OCT4 Antibody (NB100-2379) (4)

Read what people are writing who have used OCT4 Antibody (NB100-2379).

We have publications tested in 3 confirmed species: Human, Rat, Bovine.

We have publications tested in 2 applications: WB, ICC/IF.

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Product General Protocols

View specific protocols for OCT4 Antibody (NB100-2379): Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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FAQs for OCT4 (3)

  1. We are looking for the following markers to use to stain cells derived from both human and mouse embryonic and induced pluripotent stem cells: undifferentiated cells, neurons, oligodendrocytes, and astrocytes.
    • For ES markers some popular targets are OCT4 (NB100-2379), KLF4 (NBP2-17070) and SOX2 (NB110-37235). PEA15 is expressed in Astrocytes and this might be one of interest for you (NBP1-61390). OCT4 is one that can also be expressed in Oligodendrocytes.
  2. In the immunohistochemistry paraffin section protocol....the PBS buffer....should it be at certain pH?
    • For IHC application, different labs cites the pH of PBS buffer in the range of 7.1 - 7.6 but most commonly used pH is pH 7.4 (this is what we use in our lab). You may use this PBS (pH 7.4) for making permeablization buffer, antibody diluent buffers and for making wash buffer. For more on the protocol that we use in our lab and for IHC-P troubleshooting suggestions, you may visit: IHC-P Protocol and IHC-P Troubleshooting.
  3. I was wondering what does Format 7C mean as far as anitbodies go?
    • 7C is a fluorophore - it is useful for FLOW. The details of the fluor are (A=425, E=500)

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Rabbit Polyclonal
Species Human
Applications WB, ELISA

MAB2018
Western Blot: SOX2 Antibody (245610) [MAB2018] - Lysates of BG01V human embryonic stem cells and NTera-2 human testicular embryonic carcinoma cell line. PVDF membrane was probed with 0.2 ug/mL of Human/Mouse SOX2 Monoclonal Antibody (R&D catalog # MAB2018) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (R&D catalog # HAF007). This experiment was conducted under reducing conditions.Immunocytochemistry/Immunofluorescence: SOX2 Antibody (245610) [MAB2018] - E-Cadherin and SOX2 were detected in BG01V human embryonic stem cells using 10 ug/mL Human E-Cadherin Antigen Affinity-purified Polyclonal Antibody (R&D catalog # AF648) and 10 ug/mL Human/Mouse SOX2 Monoclonal Antibody (R&D catalog # MAB2018). Cells were incubated with primary antibodies for 3 hours at room temperature. Cells were stained for E-Cadherin using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (green; R&D catalog # NL001) and for SOX2 using the NorthernLights 493-conjugated Anti-Mouse Secondary Antibody (red; R&D catalog # NL009). Cells were counterstained with DAPI (blue).Flow (Intracellular): SOX2 Antibody (245610) [MAB2018] - SOX2 was detected in immersion fixed BG01V human embryonic stem cells using Human/Mouse SOX2 Monoclonal Antibody (R&D catalog # MAB2018) at 10 ug/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Mouse IgG Secondary Antibody (yellow; R&D catalog # NL007) and counterstained with DAPI (blue).

Mouse Monoclonal
Species Human, Mouse
Applications WB, Simple Western, ICC/IF...MORE

22 Publications
NB600-302
Western Blot: c-Myc Antibody (9E10) [NB600-302] - Analysis of c-myc in Jurkat cell lysates using NB600-302.Immunocytochemistry/Immunofluorescence: c-Myc Antibody (9E10) [NB600-302] - HeLa cells stained NB600-302 (Green) detected with DyLight Fluor 488 conjugated anti-mouse IgG secondary antibody.  Nuclei are counterstained with Hoechst 33258 (Blue).Simple Western: c-Myc Antibody (9E10) [NB600-302] - Simple Western lane view shows a specific band for c-Myc in 0.5 mg/ml of Jurkat lysate.  This experiment as performed under reducing conditions using the 12-230 kDa separation system.

Mouse Monoclonal
Species Human, Mouse, Drosophila
Applications WB, Simple Western, ChIP...MORE

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NBP2-24749
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AF-250-NA
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1 Publication
NB100-1831
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Applications WB, Simple Western, FLOW...MORE

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Goat Polyclonal
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Western Blot: steroid sulfatase Antibody [NBP1-69686] - This Anti-STS antibody was used in Western Blot of Placenta tissue lysate at a concentration of 1ug/ml.Immunohistochemistry-Paraffin: Steroid sulfatase Antibody [NBP1-69686] - Immunolocalization of Steroid Sulfatase in normal human endometrium  in proliferative phase of the menstrual cycle using NBP1-69686 at a concentration of 4ug/mlImmunohistochemistry-Paraffin: Steroid sulfatase Antibody [NBP1-69686] - Immunolocalization of Steroid Sulfatase in human endometrial tissue sample with endometrial cancer type I using NBP1-69686 at a concentration of 4ug/ml

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-P

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Mouse Monoclonal
Species Human, Mouse
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Western Blot: CD44 Antibody (8E2F3) [NBP1-47386] - Western blot analysis using anti-CD44 mAb against Hela (1) and HUVE-12 (2) cell lysates.Immunocytochemistry/Immunofluorescence: CD44 Antibody (8E2F3) [NBP1-47386] - Confocal analysis of paraffin-embedded human lung cancer tissues using anti-CD44 mAb (green), showing membrane localization. Blue: DRAQ5 fluorescent DNA dye.Immunohistochemistry-Paraffin: CD44 Antibody (8E2F3) [NBP1-47386] - Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissues, showing membrane localization with DAB staining using anti-CD44 mAb.

Mouse Monoclonal
Species Human, Mouse, Rabbit (Negative)
Applications WB, ELISA, FLOW...MORE

     1 Review

4 Publications
AF-233-NA
Immunohistochemistry-Paraffin: FGF basic/FGF2 Antibody [AF-233-NA] - FGF basic was detected in immersion fixed paraffin-embedded sections of human placenta using Goat Anti-Human FGF basic Antigen Affinity-purified Polyclonal Antibody (R&D catalog # AF-233-NA) at 10 ug/mL overnight at 4 °C. Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (R&D catalog # CTS013). Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; R&D catalog # CTS008) and counterstained with hematoxylin (blue). Specific staining was localized to trophoblast cells in chorionic villi.Blocking/Neutralizing: FGF basic/FGF2 Antibody [AF-233-NA] - Bovine FGF basic (R&D catalog # 133-FB) stimulates proliferation in the NR6R-3T3 mouse fibroblast cell line in a dose-dependent manner (orange line). Proliferation elicited by Bovine FGF basic (0.5 ng/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Human FGF basic Antigen Affinity-purified Polyclonal Antibody (R&D catalog # AF-233-NA). The ND50 is typically 0.08-0.4 ug/mL.

Goat Polyclonal
Species Human
Applications WB, B/N, IHC...MORE

13 Publications
NBP2-31143
Western Blot: CTLA4 Antibody (37B3D8.2F2) [NBP2-31143] - WB analysis of CTLA-4 protein on (A) mouse Kidney lysate (B) human Kidney lysate and on © partial recombinant protein using CTLA-4 monoclonal antibody at a concentration of 2 ug/ml.

Mouse Monoclonal
Species Human, Mouse
Applications WB

NB100-65423
Flow Cytometry: HLA DQ/DR Antibody (49.1) [NB100-65423] - Staining of sheep peripheral blood lymphocytes with MOUSE ANTI OVINE MHC CLASS II DQ/DR (POLYMORPHIC).

Mouse Monoclonal
Species Human, Bovine, Goat...MORE
Applications FLOW, IHC, IHC-Fr...MORE

Bioinformatics Tool for OCT4

Discover related pathways, diseases and genes to OCT4. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Bioinformatics Tool

Blogs on OCT4

Check out the latest blog posts on OCT4.
Nanog is a Master Controller of ES cell Pluripotency
Nanog, a homeodomain (HD) transcription factor, plays a critical role in the maintenance of embryonic stem (ES) cell self-renewal. Transcription regulator involved in inner cell mass and ES cell proliferation and self-renewal. Imposes pluripotency on ...  Read full blog post.

Histones, Bmi1 & OCT4: Investigating the Secrets of ESC Pluripotency
Epigenetic alterations have come to prominence in biomedical research. In particular, hypermethylation of CpG islands located in the promoter regions of tumor-suppressor genes is now firmly established as an important mechanism for gene inactivation i...  Read full blog post.

Sox2 and Oct4: Roles in Embryonic Stem Cell Pluripotency
Embryonic stem (ES) cells are cells derived from the inner cell mass of the blastocyst, an early-stage embryo. ES cells are distinguished from other cells due to their pluripotency, which is the ability to differentiate into any different type of cell...  Read full blog post.

An Unlikely Pairing: The SOX2 Antibody and Breast Cancer
SOX2 encodes a member of the SOX (SRY-related HMG-box) family of transcription factors, which play a vital role in embryonic development. SOX2 antibody research has identified Sox2 as a key transcription factor in pluripotent stem cells. We at Novus B...  Read full blog post.

The Sox2 Antibody Aids Brain Cancer Research
The Sox2 antibody is widely used in sensory, neuroscience and stem cell marker research. Recently, Sox2 antibody preparations identified the Sox2 protein as a marker for malignant neural gliomas. We at Novus Biologicals offer a wide variety of highly ...  Read full blog post.

Not as Pluripotent as You Used to Be: Embryonic Stem Cell Markers and the Aging Process
We at Novus Biologicals recently extended our antibody catalog to include several embryonic stem cells (ESC) antibodies validated for use in FACS (fluorescent activated cell sorting) assays. Among them was Oct4, which recently became the focus of an i...  Read full blog post.

Fluorescence Activated Cell Sorting Antibody Techniques
Recently, we at Novus Biologicals added several embryonic stem cell marker products to our antibody catalog, validated for use in fluorescent activated cell sorting (FACS) assays. They included Cripto1, PODXL, SSEA, OCT4, Nanog, SOX2, TRA-1, TERT and ...  Read full blog post.