Neuropeptide Y Antibody

A gene located on chromosome 7p15.1 encodes a 36-amino acid protein designated NPY (Neuropeptide Y). NPY consists of a polyproline stretch followed by an amphipathic alpha-helix. NPY shares a 50% amino acid homology with pancreatic polypeptide gene (PP). The NPY hormone family consists of NPY, PP and peptide YY. NPY is expressed throughout the central and peripheral nervous system, particularly in the deep layers of the cortex and smaller cell bodies in the white matter. NPY interacts with the Y-receptor family of G-protein coupled receptors. NPY interacts with NPY receptor Y1 to increase corticotropin levels and decrease noradrenaline levels in the hypothalamus. Through interactions in the hypothalus, NPY plays important roles in the regulation of energy balance by stimulating food intake. NPY favors energy storage by increasing lipoprotein lipase activity in white adipose tissue. A leucine(7)-to- proline(7) polymorphism has been implicated in an increase in alcohol preference, and decrease in cholesterol metabolism.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 3 applications: ICC/IF, IF/IHC, IHC-Fr.

Showing Publications 1 - 5 of 5.

Publications using NBP1-19808	Applications	Species
Wang, L;De Solis, AJ;Goffer, Y;Birkenbach, KE;Engle, SE;Tanis, R;Levenson, JM;Li, X;Rausch, R;Purohit, M;Lee, JY;Tan, J;De Rosa, MC;Doege, CA;Aaron, HL;Martins, GJ;Bruning, JC;Egli, D;Costa, R;Berbari, N;Leibel, RL;Stratigopoulos, G; Ciliary gene RPGRIP1L is required for hypothalamic arcuate neuron development JCI Insight 2019-02-07 [PMID: 30728336] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Dominguez JM, Yorek MA, Grant MB. Combination therapies prevent the neuropathic, pro-inflammatory characteristics of the bone marrow in streptozotocin-induced diabetic rats. Diabetes. 2014-09-09 [PMID: 25204979]
Makinde TO, Steininger R, Agrawal DK. NPY and NPY receptors in airway structural and inflammatory cells in allergic asthma Exp Mol Pathol 2012-06-12 [PMID: 22705097] (IF/IHC, ICC/IF, Mouse)	IF/IHC, ICC/IF	Mouse
Zauderer M, Fisher T, Mishra V et al. SEMA4D upregulation signals neuronal stress and triggers reactive transformation of astrocytes Research Square 2021-01-19 (IF/IHC, Mouse)	IF/IHC	Mouse
Evans EE, Mishra V, Mallow C et al. Semaphorin 4D is upregulated in neurons of diseased brains and triggers astrocyte reactivity Journal of neuroinflammation 2022-08-06 [PMID: 35933420]

Array NBP1-19808

• Neuropeptide Y Antibodies
• Neuropeptide Y ELISA Kits
• Neuropeptide Y Proteins
• Neuropeptide Y ELISA