NBS1 Antibody (NBP1-06705) | Novus Biologicals

NBS1 Antibody (NBP1-06705) (0.1 ml)

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	Catalog Number	NBP1-06705 (Sample Size Available)
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anti-p95 protein of the MRE11/RAD50 complex antibody, anti-Nijmegen breakage syndrome 1 (nibrin) antibody, anti-ATV antibody, anti-MGC87362 antibody, anti-AT-V2 antibody, anti-FLJ10155 antibody, anti-AT-V1 antibody, anti-NBS1P95 antibody, anti-NBSNijmegen breakage syndrome protein 1 antibody, anti-Cell cycle regulatory protein p95 antibody, anti-nibrin antibody

NBS1 Antibody Summary:

Species:	Hu, Mu	Gene:	NBN
Applications:	WB, IHC-P	Purity:	Peptide affinity purified
Clonality:	Polyclonal	Host:	Rabbit
Specificity:	NBS1
Publications:	NBP1-06705 has been mentioned in at least 1 Publication

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Lysates	Peptides and Proteins
Primary Antibodies	RNAi
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NBS1 Antibody Details:

Immunogen:	Synthetic peptide made to an internal portion of the mouse protein (within residues 150-200). [Swiss-Prot# Q9R207]
Localization:	Nucleus. Telomere. Note= Localizes to discrete nuclear foci after treatment with genotoxic agents.

Species Reactivity:

Human and mouse.

Applications:

Uses:	This antibody is useful for Western blot, where a band is seen at approx. 97 kDa. The antibody is also useful for immunohistochemistry-paraffin embedded sections.
Dilutions:	Western Blot 0.5 ug/ml, Immunohistochemistry-Paraffin 1:100
Unit Size:	0.1 ml (also available: 0.025 ml (sample size))
Concentration:	1.48 mg/ml
Positive Controls:	2 Positive Controls
Conjugated Antibodies:	5 Conjugated Antibodies

Packaging:

Storage:	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Buffer:	PBS, 30% glycerol
Preservative:	0.1% Sodium Azide
Limitations:	This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.

Gene Symbol: NBN

Entrez:	4683 (Human)
Entrez:	27354 (Mouse)
Uniprot:	Q9R207 (Mouse)

Related Genes:

Background:

The p95 gene (identical to NBS1 and nibrin) is a member of the hMre11/hRad50 double-strand break complex. This protein complex has been implicated in Nijmegen breakage syndrome, an autosomal recessive disorder marked by increased cancer incidence, cell cycle checkpoint deficits, and ionizing radiation sensitivity, thus revealing a direct molecular link between double-strand break repair and cell cycle checkpoint functions.

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