Sirtuin 1/SIRT1 [p Ser47] Antibody (EPR2849Y)

Name: Sirtuin 1/SIRT1 [p Ser47] Antibody (EPR2849Y)
Brand: Novus Biologicals
SKU: NBP1-40486
Price: 399 USD
Availability: Discontinued

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NBP1-40486
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Sirtuin 1/SIRT1 [p Ser47] Antibody (EPR2849Y) Summary

Immunogen	A phospho specific peptide corresponding to residues surrounding serine 47 of human Sir2/SIRT1 was used as an immunogen.
Modification	p Ser47
Specificity	This antibody detects Sir2/SIRT1 phosphorylated on ser 47
Isotype	IgG
Clonality	Monoclonal
Host	Rabbit
Gene	SIRT1
Purity	Tissue culture supernatant
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Applications/Dilutions

Dilutions	Immunocytochemistry/ Immunofluorescence 1:100-250 Immunohistochemistry 1:10-1:500 Immunohistochemistry-Paraffin 1:250-500 Western Blot 1:1000-2000
Application Notes	This product is useful for: Western Blot, Immunohistochemistry-Paraffin, Immunocytochemistry. In Western blot this antibody detects a band at approximately 110kDa.
Theoretical MW	110 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Reacts with: Human Does not react with Mouse, Rat

Packaging, Storage & Formulations

Storage	Store at -20C. Avoid freeze-thaw cycles.
Buffer	49% PBS, 0.05% BSA and 50% Glycerol
Preservative	0.01% Sodium Azide
Purity	Tissue culture supernatant

Notes

Produced using Abcam's RabMab® technology. RabMab® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

Alternate Names for Sirtuin 1/SIRT1 [p Ser47] Antibody (EPR2849Y)

EC 3.5.1
S. cerevisiae, homolog) 1
SIR2alpha
SIR2L1
SIR2-like protein 1
SIRT1
Sirtuin 1

Background

Sirt1, an HDAC human homologue of the yeast Sir2 protein important in establishing repressive chromatin structures, has been found to associate with the tumor suppressor protein p53. It binds and deacetylates p53 in response to the upregulation of promyelocytic leukemia protein (PML) nuclear bodies or oncogenic Ras. The deacetylation of p53 SIRT1 has been shown to negatively regulate p53-mediated transcription, preventing cellular senescence and apoptosis induced by DNA damage and stress. It has also been shown to play a role in increasing lifespan.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol	SIRT1
Entrez	23411(Human)
Uniprot	Q96EB6(Human)

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Sirtuin 1/SIRT1 [p Ser47] Antibody (EPR2849Y)

Species Glossary

Images

Product Details

Order Details

Sirtuin 1/SIRT1 [p Ser47] Antibody (EPR2849Y) Summary

Applications/Dilutions

Reactivity Notes

Packaging, Storage & Formulations

Notes

Alternate Names for Sirtuin 1/SIRT1 [p Ser47] Antibody (EPR2849Y)

Background

Limitations

Customers Who Viewed This Item Also Viewed...

Publications for Sirtuin 1/SIRT1 Antibody (NBP1-40486) (0)

Reviews for Sirtuin 1/SIRT1 Antibody (NBP1-40486) (0)

Product General Protocols

Video Protocols

FAQs for Sirtuin 1/SIRT1 Antibody (NBP1-40486) (0)

Secondary Antibodies

Isotype Controls

Additional Sirtuin 1/SIRT1 Products

Research Areas for Sirtuin 1/SIRT1 Antibody (NBP1-40486)

Blogs on Sirtuin 1/SIRT1

Contact Information

Product PDFs

Calculators

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Bioinformatics