Angiotensin Converting Enzyme 1 Lysate

Applications: WB

Gene: ACE Purity: Protein

Specificity:	Homo sapiens angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 (ACE), transcript variant 3, mRNA.

Immunogen:	The lysate was created in HEK293T cells, using plasmid ID RC205392 and based on accession number NM_152831.

Type: Overexpression Tissue Condition: Normal

Life Stage: Adult Protein State: Native Sub-cellular Fraction: Whole

Entrez:	1636 (Human)
Swiss Prot:	NM_152831 (Human)
Related Genes:	AGT, AGT, REN, REN, KNG1, AGT, MME, ANG, ANG, ANG, 2010317E24RIK, ATP2A2, MME, AKR1C2, MME, INS, AGTRAP, AGTR1A, AGTR1, ID1, ATP8B2, ID1, ALB, ALB, BEST1, ALB, AGTR1A, AGTR1B, SLC33A1, DDR1, TENC1, DDR1, ATM, TNF, RAPGEF5, RAPGEF5, AGXT, NOS3, MGMT, TNF

This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Two most abundant alternatively spliced variants of this gene encode two isozymes - the somatic form and the testicular form that are equally active. Multiple additional alternatively spliced variants have been identified but their full length nature has not been determined. Transcript Variant: This variant (3) differs in the 5' and 3' UTR and includes an alternate in-frame exon in the 5' coding region, compared to variant 1. It also uses an alternate splice site in the 3' coding region, compared to variant 1, that results in a frameshift. Isoform (3) is shorter and has a distinct N- and C-terminii, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Uses:	This product is intended for use as a positive control in Western Blot.
Dilutions:	Western Blot
Concentrations:	1 mg/ml

This product is manufactured by and sold under license from OriGene Technologies and its use is limited solely for research purposes.

Buffer:	This product is provided in modified RIPA buffer.
Storage:	Store at -20C. Avoid freeze-thaw cycles.
Limitations:	This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.