58K golgi protein Antibody (58K-9) - Golgi Complex Marker

Species: Rt, Hu, Ha, Ca Applications: ICC, WB, IF, IHC Clonality: Monoclonal	Gene: FTCD Purity: Ascites Host: Mouse
Specificity: The product recognizes an epitope located on the microtubule-binding peripheral Golgi membrane 58 kDa protein. Publications: Antibody has been mentioned in at least 2 publications.
See All 58K golgi protein Products See All 58K golgi protein Related Products: Peptides and Proteins Primary Antibodies RNAi
*Note not all species have been tested for reactivity. Only those species listed have been tested. We cannot make any guarantees about additional reactivities or cross reactivities beyond those that have been tested. This antibody may or may not react with other species.

Clone:	58K-9
Isotype:	IgG1
Immunogen:	Full length native protein (purified) (Rat liver).
Marker:	Golgi Complex Marker
Localization:	Cytoplasmic and Golgi Apparatus

	89833 (Rat)
Related Genes:	GOLPH3, VIM, MTAP1B, CYP2D6, GFAP, CYP2D4V1, GNMT, AHCY, SQSTM1, ARHGEF5, GLTSCR2, CTLA4, TNFRSF1A, PPR1, ABO2, ABO, GPT, HNRNPC, BCL9, CLTC, QPCT, LMNA, GOLGA2, ARHGAP4, ATP8A2, SERPINH1, YIF1, SCYL1, TST, USO1, ACOX1, XRCC5, PPIA, MTHFR, VCL, GPC3, CCL13, CBS, PEX6, EXOSC10

58K protein antibodies are excellent for use as markers for the Golgi complex. The 58K protein has been identified as being FTCD, a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a metabolite of the histidine degradation pathway, to the folate pool. Defects in FTCD are the cause of glutamate formiminotransferase deficiency; also known as formiminoglutamicaciduria (FIGLU-uria). It is an autosomal recessive disorder. Features of a severe phenotype, include elevated levels of formiminoglutamate (FIGLU) in the urine in response to histidine administration, megaloblastic anemia, and mental retardation. Features of a mild phenotype include high urinary excretion of FIGLU in the absence of histidine administration, mild developmental delay, and no hematological abnormalities.

Reactivity:	Cross-reacts with Dog, Hamster, Human, and Rat. Not yet tested in other species. It is predicted to react with Cow and Pig due to sequence homology.

Uses:	The antibody is useful for immunofluorescence and Western Blot.
Dilutions:	immunohistochemistry , immunofluorescence 1:50, Western Blot 1:5000, Immunocytochemistry
Concentrations:	3.6 mg/ml

Storage:	Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Preservative:	15mM Sodium Azide
Limitations:	This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.