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Clonality:	Polyclonal
Specificity:	Specific for ABCG8.
Purity:	Immunogen affinity purified
Host:	Rabbit

Immunogen:	A synthetic peptide from the N-terminal region of human ABCG8 protein.
Localization:	Integral membrane protein; multi-pass membrane protein

Entrez:	64241 (Human)
	67470 (Mouse)
Swiss Prot:	Q9H221 (Human)

ATP-binding cassette (ABC) transporter genes are involved in the regulation of the amount of dietary cholesterol retained in the body. ABCG8, expressed at high levels in the liver and intestine, normally cooperates with ABCG5 to limit intestinal absorption and promote biliary excretion of sterols. The mutated form of this transporter can lead to sterol accumulation and atherosclerosis or sitosterolemia, a rare autosomal recessive disorder, characterized by hyperabsorption of sterols and the inability to excrete sterols into bile.

	Mouse (-), Human
Reactivity:	Human. Does not appear to cross react with mouse..
*Note not all species have been tested for reactivity. Only those species listed have been tested. We cannot make any guarantees about additional reactivities or cross reactivities beyond those that have been tested. This antibody may or may not react with other species.

	WB
Uses:	It does not appear to be applicable in immunohistochemistry.
Dilutions:	Western Blot 1:500
Conjugated Ab's:	5 conjugated antibodies

Storage:	Store at 4C. Do not freeze.
Buffer:	PBS
Preservative:	0.1% Sodium Azide
Unit Size:	0.1ml (also available: 0.025ml (sample size))
Concentration:	1.0 mg/ml
Limitations:	This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.

1. Kobayashi, A., et al. Efflux of sphingomyelin cholesterol phosphatidylcholine by ABCG1. J. Lipid Res. 47:1791-1802, 2006.
2. Mathur, S. N., Watt, K. R., Field, F. J. (2007) Regulation of intestinal NPC1L1 expression by dietary fish oil docosahexaenoic acid, 48, 395-404.

2 publications available on website

 

Western Blot: ABCG8 Antibody [NB400-110] - Western blot analysis of ABCG8, using NB400-110. Samples: mouse liver microsomes from G5/G8 knockout mice, wildtype human G5/G8, and transgenic human G5/G8.

2 Peptides and Proteins

6 Primary Antibodies

1 RNAi

123 Secondary Antibodies

ABCG5, ABCA1, NPC1L1, SCARB1, NR1H2, ABCB11, ABCB1A, CYP7A1, ABCB4, NR1H4, ABCG1, SREBF2, LDLR, PRL2C3, ABCC1, ABCC3, ABCC2, HMGCR, ABCA13, SREBF1, SOAT2, STN, APOA1, KLHL1, CCL9, BAT5, BAT4, NR0B2, SYCE1L, HNRNPC, ARHGAP4, ABCG2, PFDN4, NR1H3, PPARA, SLCO1A1, MTTP, SLCO1A2, INS, SLC10A1

General Protocols

• Protocol specific for ABCG8 Antibody (NB400-110)