Novus Biologicals, LLC
PO Box 802; Littleton, CO, 80160 USA
Phone: 303.730.1950 Fax: 303.730.1966
ABCG8 Antibody (NB400-110)
ABCG8 Antibody
| Catalog#: | NB400-110 |
This product is fully covered under guarantee+ |
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| Storage: | Store at 4C. Do not freeze. |
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| Buffer: | PBS |
| Preservative: | 0.1% Sodium Azide |
| Purity: | Immunogen affinity purified |
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| Host: | Rb |
| Clonality: | Polyclonal |
| Specificity: | Specific for ABCG8. |
| Modification: | No |
| Immunogen: | A synthetic peptide from the N-terminal region of human ABCG8 protein. |
| Entrez: | 64241 (Human) |
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| 67470 (Mouse) | |
| Related Genes: | 64241 |
| Swiss Prot: | Q9H221 (Human) |
Background:
ATP-binding cassette (ABC) transporter genes are involved in the regulation of the amount of dietary cholesterol retained in the body. ABCG8, expressed at high levels in the liver and intestine, normally cooperates with ABCG5 to limit intestinal absorption and promote biliary excretion of sterols. The mutated form of this transporter can lead to sterol accumulation and atherosclerosis or sitosterolemia, a rare autosomal recessive disorder, characterized by hyperabsorption of sterols and the inability to excrete sterols into bile.
| Mu(-), Hu | |
| reactivity: | Human. Does not appear to cross react with mouse.. |
| WB | |
| Uses: | It does not appear to be applicable in immunohistochemistry. |
| Dilutions: | Western Blot 1:500 |
| Publications: | Kobayashi, A., et al. Efflux of sphingomyelin cholesterol phosphatidylcholine by ABCG1. J. Lipid Res. 47:1791-1802, 2006. Mathur, S. N., Watt, K. R., Field, F. J. (2007) Regulation of intestinal NPC1L1 expression by dietary fish oil docosahexaenoic acid, 48, 395-404. |
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Protocols
General Protocols
Reviews
No reviews have been submitted for this product.
Working with ABCG8
Publications (2)
Product Specific:
Kobayashi, A., et al. Efflux of sphingomyelin cholesterol phosphatidylcholine by ABCG1. J. Lipid Res. 47:1791-1802, 2006.
Mathur, S. N., Watt, K. R., Field, F. J. (2007) Regulation of intestinal NPC1L1 expression by dietary fish oil docosahexaenoic acid, 48, 395-404.
Images (1)
![Western Blot: ABCG8 Antibody [NB400-110] - Western blot analysis of ABCG8, using NB400-110. Samples: mouse liver microsomes from G5/G8 knockout mice, wildtype human G5/G8, and transgenic human G5/G8.](/sites/default/files/p_43e3c097a1236.jpg "Western Blot: ABCG8 Antibody [NB400-110] - Western blot analysis of ABCG8, using NB400-110. Samples: mouse liver microsomes from G5/G8 knockout mice, wildtype human G5/G8, and transgenic human G5/G8.")
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Western Blot: ABCG8 Antibody [NB400-110] - Western blot analysis of ABCG8, using NB400-110. Samples: mouse liver microsomes from G5/G8 knockout mice, wildtype human G5/G8, and transgenic human G5/G8. |
Protocols/Procedures (1)
Additional General Protocols
- Protocol specific for ABCG8 Antibody (NB400-110)