Peripherin Antibody

Species: Ma, Hu Applications: IHC-P, ICC, WB, IF, IHC, ELISA Clonality: Polyclonal

Gene: PRPH Purity: Whole antisera Host: Rabbit

Specificity:	Specifically recognizes peripherin, showing no cross reactivity with other Class III intermediate filament proteins.
Publications:	Antibody has been mentioned in at least 3 publications.

Immunogen:	Recombinant full length rat peripherin
Localization:	Neuronal Marker

Entrez:	5630 (Human)
Related Genes:	GFAP, PRPH2, RHO, RHO, RHO, ROM1, NGF, NEFL, NEFM, ROM1, ROM1, VIM, VIM, VIM, NEFL, NEFL, PRPH2, NEFM, CALCA, GFAP, NEFH, GFAP, NFASC, NFASC, NFASC, CEBPB, NGF, NGF, NES, NES, NES, MERTK, SOD1, ERG, KCNH2, ERG, KCNH2, ERG, KCNH2, RP

Peripherin is a Class III intermediate filament subunit found in both the peripheral and central nervous systems, though it is concentrated, as its name suggests, in the neurons of peripheral ganglia and their processes. Antibodies to peripherin can be used in identifying, classifying, and studying neurons in the nervous system. Peripherin is also a good diagnostic marker for ballooned axons seen in Lou Gehrig's disease and some neuronally derived tumors. Peripherin is also a major component of the cytoskeleton of PC12 cells, widely used model system for studies of neuronal differentiation. Autoantibodies to peripherin are frequently seen in the sera of patients with diabetes. Peripherin is not related to peripherin-RDS, a photoreceptor protein associated with retinal degeneration and blindness.

Reactivity:	Human and all other mammalian species to date. Results on avian tissues are however not conclusive.

Uses:	Can be used on formalin-fixed paraffin-embedded histological sections, immunocytochemistry, ELISA, Immunofluorescence and Western blotting. A band at ~57 kDa can be seen in Western blotting.
Dilutions:	ELISA, immunohistochemistry, immunofluorescence 1:1000, Western Blot 1:5000, Immunocytochemistry, Immunohistochemistry-Paraffin,

Storage:	Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Preservative:	No Preservative
Limitations:	This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.