Adiponectin Antibody (Ne.Na)

Species: Mu(-), Hu Applications: WB, IP, ELISA Clonality: Monoclonal	Gene: ADIPOQ Purity: Affinity purified Host: Mouse
Specificity: Acrp30 (Ne.Na)
See All Adiponectin Products See All Adiponectin Related Products: Kits Peptides and Proteins Primary Antibodies RNAi
*Note not all species have been tested for reactivity. Only those species listed have been tested. We cannot make any guarantees about additional reactivities or cross reactivities beyond those that have been tested. This antibody may or may not react with other species.

Clone:	Ne.Na
Isotype:	IgG1
Immunogen:	Recombinant human ACRP30 headless (tail adiponectin) protein.
Localization:	Secreted

Entrez:	9370 (Human)
	11450 (Mouse)
Related Genes:	INS, LEP, TNF, IL6, RETN, CRP, ADIPOR1, PRKAA2, GRPCB, CRIP2, DMBT1, CSRP1, ADIPOR2, CCL2, SERPINE1, NAMPT, PPARG, INSR, TG, PPARA, AKT1, GH, SLC2A4, SERPINE2, LPL, MAPK3, ALB, IL10, AGT, FABP4, MCPT1, ZBTB7C, NOS3, RBP4, SHBG, LEPR, ERMAP, NPPB, MAPK1, SLC17A5

Adipose cells produce and secrete numerous physiologically important proteins, such as Lipoprotein Lipase, Leptin, and Adipocyte Complement Related protein of 30 kDa, also known as Acrp30 or Adiponectin. Adiponectin is a circulating protein that is secreted exclusively by differentiated adipocytes. During adipocyte differentiation, Adiponectin mRNA is induced >100 fold. Adiponectin improves the ability of insulin to suppress glucose production, at sub physiological levels, thereby linking adipose tissue to whole body glucose regulation. Adiponectin function appears to be regulated by phosphatidylinositol 3 kinase (PI3K) since Adiponectin secretion is blocked by pharmacologic inhibitors of this kinase. Adiponectin mRNA is significantly reduced in adipose tissue of obese patients with Type 2 diabetes. The structural similarity of Adiponectin to TNF alpha suggests that Adiponectin may play a role in pathogenesis of insulin resistance in Type 2 diabetes. Adiponectin is implicated as a regulator of whole body energy homeostasis.

Reactivity:	Cross-reacts with Human.Does not cross-react with Mouse.Not yet tested in other species.

Uses:	ELISA: Use at an assay dependent dilution. IP: Use at an assay dependent dilution. WB: Use at a concentration of 1 ug/ml. Predicted molecular weight: 29 kDa. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user.
Dilutions:	ELISA, immunoprecipitation, Western Blot
Concentrations:	1.0 mg/ml
Positive Controls:	1 positive controls

Buffer:	PBS
Storage:	Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Preservative:	0.02% Sodium Azide
Limitations:	This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.