ACCN1 Antibody

Catalog#:	NB110-74733	This product is fully covered under guarantee+

Storage:	Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer:	Lyophilized
Preservative:	No Preservative

Purity:	Whole antisera
Host:	Rb
Clonality:	Polyclonal
Specificity:	ASIC2.
Modification:	No
Immunogen:	A synthetic peptide as a part of human & monkey (macaca fascicularis) amiloride-sensitive cation channel 1 (ASIC1) conjugated to immunogenic carrier protein was used as the immunogen.

Entrez:	40 (Human)
Omim:	ASIC1_HUMAN ; ASIC1_MONKEY (Human)
Related Genes:	40
Swiss Prot:	Q16515 (Human)

ACCN1 is a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. ACCN1 may play a role in neurotransmission. In addition, a heteromeric association between ACCN1 and ACCN3 (variant 1) has been observed to co-assemble into proton-gated channels sensitive to gadolinium. FUNCTION: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate. SUBUNIT: Homotetramer or heterotetramer with other ASIC proteins (Probable). Interacts with STOM. Interacts with PRKCABP and ACCN3. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Note=Localized at the plasma membrane of neurons, in the soma and punctated peripheral processes.

	Hu
reactivity:	Human. .

	WB, IHC
Uses:	Immunohistochemistry and Western Blot
Dilutions:	immunohistochemistry Western Blot 1:300
Positive Controls:	ACCN1 Lysate (ACCN1 Lysate (NBL1-07230)(0.1mg))

Publications:	Price M.P, et al. J. Biol. Chem. 271:7879-7882(1996). Waldmann R, et al. J. Biol. Chem. 271:10433-10436(1996). Garcia-Anoveros J, et al. Proc. Natl. Acad. Sci. U.S.A. 94:1459-1464(1997). 5 publications available on website

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Reconstitute in 0.1 ml of sterile water. Centrifuge to remove any insoluble material. When reconstituting, glycerol (1:1) may be added for an additional stability.