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Clonality:	Polyclonal
Specificity:	ASIC2.
Purity:	Whole antisera
Host:	Rabbit

Immunogen:	A synthetic peptide as a part of human & monkey (macaca fascicularis) amiloride-sensitive cation channel 1 (ASIC1) conjugated to immunogenic carrier protein was used as the immunogen.
Localization:	Cell Membrane; multi-pass membrane protein

Entrez:	40 (Human)
Omim:	ASIC1_HUMAN ; ASIC1_MONKEY (Human)
Swiss Prot:	Q16515 (Human)

ACCN1 is a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. ACCN1 may play a role in neurotransmission. In addition, a heteromeric association between ACCN1 and ACCN3 (variant 1) has been observed to co-assemble into proton-gated channels sensitive to gadolinium. FUNCTION: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate. SUBUNIT: Homotetramer or heterotetramer with other ASIC proteins (Probable). Interacts with STOM. Interacts with PRKCABP and ACCN3. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Note=Localized at the plasma membrane of neurons, in the soma and punctated peripheral processes.

	Human
Reactivity:	Human. .
*Note not all species have been tested for reactivity. Only those species listed have been tested. We cannot make any guarantees about additional reactivities or cross reactivities beyond those that have been tested. This antibody may or may not react with other species.

	WB, IHC
Uses:	Immunohistochemistry and Western Blot
Dilutions:	immunohistochemistry Western Blot 1:300
Positive Controls:	ACCN1 Lysate (ACCN1 Lysate (NBL1-07230)(0.1mg))

Storage:	Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer:	Lyophilized
Preservative:	No Preservative
Limitations:	This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.

1. Price M.P, et al. J. Biol. Chem. 271:7879-7882(1996).
2. Waldmann R, et al. J. Biol. Chem. 271:10433-10436(1996).
3. Garcia-Anoveros J, et al. Proc. Natl. Acad. Sci. U.S.A. 94:1459-1464(1997).

5 publications available on website

ACCN2, ACCN3, PICK1, ACCN4, DRG1, STOM, LBR, ATP8B1, ACCN5, BDNF, SCNN1G, TRPV1, QPCT, DLG4, SCNN1D, SCNN1B, HSPA8, SCNN1A, BNC1, BNC2, NTRK1, NTF5, CFTR, NTF4, LTK, NTF3, TNFRSF11A, MSX1, CDKN1C, NPFF, TYRP1, MPP6, S100A10, TXNL1, USH1C, TRPA1, TBPL1, EIF2C2, FMR1, FUT2