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ACCN1 Antibody

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Product Details

Summary
Product Discontinued
View other related ACCN1 Primary Antibodies

Order Details


    • Catalog Number
      NB110-74733
    • Availability
      Product Discontinued

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ACCN1 Antibody Summary

Immunogen
A synthetic peptide as a part of human & monkey (macaca fascicularis) amiloride-sensitive cation channel 1 (ASIC1) conjugated to immunogenic carrier protein was used as the immunogen.
Localization
Cell Membrane; multi-pass membrane protein
Specificity
ASIC2.
Clonality
Polyclonal
Host
Rabbit
Gene
ASIC2
Purity
Unpurified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
  • Western Blot
Control
ACCN1 Overexpression Lysate

Reactivity Notes

Human.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
Whole antisera
Preservative
No Preservative
Concentration
LYOPH
Purity
Unpurified
Reconstitution Instructions
Please contact technical support for detailed reconstituion instruction.

Notes

Reconstitute in 0.1 ml of sterile water. Centrifuge to remove any insoluble material. When reconstituting, glycerol (1:1) may be added for an additional stability.

Alternate Names for ACCN1 Antibody

  • Acid-sensing ion channel 2
  • Amiloride-sensitive brain sodium channel
  • amiloride-sensitive cation channel 1, neuronal
  • ASIC2a
  • ASIC2Mammalian degenerin homolog
  • BNAC1
  • BNaC1ACCN
  • BNC1Amiloride-sensitive cation channel neuronal 1
  • degenerin
  • hBNaC1
  • MDEGBrain sodium channel 1
  • neuronal amiloride-sensitive cation channel 1

Background

ACCN1 is a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. ACCN1 may play a role in neurotransmission. In addition, a heteromeric association between ACCN1 and ACCN3 (variant 1) has been observed to co-assemble into proton-gated channels sensitive to gadolinium. FUNCTION: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate. SUBUNIT: Homotetramer or heterotetramer with other ASIC proteins (Probable). Interacts with STOM. Interacts with PRKCABP and ACCN3. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Note=Localized at the plasma membrane of neurons, in the soma and punctated peripheral processes.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

Additional ACCN1 Products

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Bioinformatics

Gene Symbol ASIC2
Entrez
Uniprot