Novus Biologicals, LLC
PO Box 802; Littleton, CO, 80160 USA
Phone: 303.730.1950 Fax: 303.730.1966
ACP1 Antibody (NB100-56474)
ACP1 Antibody
| Catalog#: | NB100-56474 |
This product is fully covered under guarantee+ |
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| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
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| Buffer: | PBS containing 0.2% gelatin |
| Preservative: | 0.05% Sodium Azide |
| Purity: | protein G purified |
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| Host: | Rb |
| Clonality: | Polyclonal |
| Specificity: | The amino acid sequence used as immunogen is 100% homologous in human, 93% in dog and orangutan, 86% in chicken and 80% homologous in mouse and rat (isoform a). It is also 100% homologous in human ACP1 isoforms c and d. An uncharacterized 45 kD band is also seen and blocked by the immunizing peptide. |
| Modification: | No |
| Isotype: | IgG |
| Immunogen: | A portion of amino acids 50-100 of human ACP1 was used as the immunogen. |
| Entrez: | 52 (Human) |
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| Related Genes: | 52 |
Background:
Official Gene Symbol: ACP1 Gen Bank Accession Number: NP_009030 Gene ID: 52 (Human) Gene Map Locus: 2p25 (Human) ACP1 (E.C 3.1.3.2) is a unique member of Phosphotyrosine Protein phosphotase family of proteins. It is ubiquitously expressed acid phosphotase functioning as an acid phosphotase and a protein tyrosine phosphotase. ACP1 has a cysteine-based catalytic mechanism and hydrolyzes protein tyrosine phosphate to protein tyrosine and orthophosphate. Reports suggest a functional role of ACP1 in TCR signaling and control of cell-cell adhesion through regulation of cytoskeletion assembly.
| Hu | |
| reactivity: | Cross reacts with Human. . |
| WB | ||
| Uses: | Western Blot | |
| Dilutions: | Western Blot 1-3 ug/ml | |
| Positive Controls: | Whole Normal Liver Lysate (Whole Normal Liver Lysate (NB820-59232)(1mg)) | ACP1 Lysate (ACP1 Lysate (NBL1-07250)(0.1mg)) |
| Publications: | Wo,Y.Y., McCormack,A.L., Shabanowitz,J., Hunt,D.F., Davis,J.P., Mitchell,G.L. Van Etten,R.L. Sequencing, cloning, expression of human red cell-type acid phosphatase, a cytoplasmic phosphotyrosyl protein phosphatase J. Biol. Chem. 267 (15), 10856-10865 (1992) Bottini et.al 277 (27) 24220-24224 (July 5, 2002) Giannoni et.al JBC 278 (38) 36763-36776 (September 19, 2003) |
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ACP1 in Context
Working with ACP1
Publications (3)
General:
Wo,Y.Y., McCormack,A.L., Shabanowitz,J., Hunt,D.F., Davis,J.P., Mitchell,G.L. Van Etten,R.L. Sequencing, cloning, expression of human red cell-type acid phosphatase, a cytoplasmic phosphotyrosyl protein phosphatase J. Biol. Chem. 267 (15), 10856-10865 (1992)
Bottini et.al 277 (27) 24220-24224 (July 5, 2002)
Giannoni et.al JBC 278 (38) 36763-36776 (September 19, 2003)
Images (1)
![Western Blot: ACP1 Antibody [NB100-56474] - Western blot analysis of ACP1 in the 1) absence and 2) presence of immunizing peptide in human liver lysate using NB100-56474 at 1 ug/ml.](/sites/default/files/p_56474_1.jpg "Western Blot: ACP1 Antibody [NB100-56474] - Western blot analysis of ACP1 in the 1) absence and 2) presence of immunizing peptide in human liver lysate using NB100-56474 at 1 ug/ml.")
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Western Blot: ACP1 Antibody [NB100-56474] - Western blot analysis of ACP1 in the 1) absence and 2) presence of immunizing peptide in human liver lysate using NB100-56474 at 1 ug/ml. |