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Sex Hormone Binding Globulin Antibody (NB100-56417)

Sex Hormone Binding Globulin Antibody

Catalog#: NB100-56417 100% Guarantee
This product is fully covered under guarantee+
Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer: PBS containing 0.2% gelatin
Preservative: 0.05% Sodium Azide
Purity: protein G purified
Host: Rb
Clonality: Polyclonal
Specificity: The NCBI accession number for ABP is NP-055407. The amino acid sequence used as immunogen is 100% homologous in human, mouse, rat, pig and bovine.
Modification: No
Isotype: IgG
Immunogen: Amino acids 11-28 (LQTKQRRPSKDKIEDELE) of human ABP protein were used as the immunogen.
Gene Symbol: SHBG 
Entrez: 6462 (Human)
20415 (Mouse)
24775 (Rat)
Related Genes: 6462
Background:
The gene encodes an EF hand-containing small calcium binding protein. It is an integral subunit component of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Kv4 potassium channels regulate action potentials in neurons and cardiac myocytes. The coexpression of ABP with pore-forming Kv4 alpha subunits causes changes in the gating and amplitude of Kv4 currents, thus profoundly affect the intracellular trafficking and molecular properties of Kv4.2 alpha subunits. It also cause a dramatic redistribution of Kv4.2, releasing intrinsic endoplasmic reticulum retention and allowing for trafficking to the cell surface. It may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. It maps to 5q35.1 region of human chromosome. Alternative splicing results in multiple transcript variant encoding different isoforms. Isoform 1 and isoform 2 are expressed in brain and kidney.
Species:
Bv, Po, Rt, Mu, Hu
reactivity: Reacts with Human, mouse, rat, porcine and bovine..
Applications:
WB
Uses: Western Blot
Dilutions: Western Blot 0.5-2 ug/ml
Positive Controls: Whole Normal Brain Lysate (Whole Normal Brain Lysate (NB820-59177)(1.0mg)) Whole Normal Heart Lysate (Whole Normal Heart Lysate (NB820-59217)(1.0mg))
Publications: Lin,Y.L., Chen,C.Y., Cheng,C.P. Chang,L.S. Protein-protein interactions of KChIP proteins Kv4.2. Biochem. Biophys. Res. Commun. 321 (3), 606-610 (2004). Nakamura,T.Y., Ni,S., Pountney,D.J., Artman,M., Rudy,B. Coetzee,W.A. Different effects of the Ca(2+)-binding protein, KChIP1, on two Kv4 subfamily members, Kv4.1 Kv4.2. FEBS Lett. 499 (3), 205-209 (2001). W. Frank An, Mark R. Bowlby, Maria Betty, Jie Cao, Huai-Ping Ling, Grace Mendoza, Joseph W. Hinson, Karen I. Mattsson, Brian W. Strassle, James S. Trimmer Kenneth J. Rhodes. Modulation of A-type potassium channels by a family of calcium sensors; Nature 403, 553-556 (3 February 2000).
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Sex Hormone Binding Globulin in Context

Research Areas related to Sex Hormone Binding Globulin (2):

Working with Sex Hormone Binding Globulin

Publications (3)
General:

Lin,Y.L., Chen,C.Y., Cheng,C.P. Chang,L.S. Protein-protein interactions of KChIP proteins Kv4.2. Biochem. Biophys. Res. Commun. 321 (3), 606-610 (2004).

Nakamura,T.Y., Ni,S., Pountney,D.J., Artman,M., Rudy,B. Coetzee,W.A. Different effects of the Ca(2+)-binding protein, KChIP1, on two Kv4 subfamily members, Kv4.1 Kv4.2. FEBS Lett. 499 (3), 205-209 (2001).

W. Frank An, Mark R. Bowlby, Maria Betty, Jie Cao, Huai-Ping Ling, Grace Mendoza, Joseph W. Hinson, Karen I. Mattsson, Brian W. Strassle, James S. Trimmer Kenneth J. Rhodes. Modulation of A-type potassium channels by a family of calcium sensors; Nature 403, 553-556 (3 February 2000).


 
Images (1)
Western Blot: ABP Antibody [NB100-56417] - Western blot analysis of ABP in (A) human brain and (B) human heart cell lysate using NB100-56417 at 1 ug/ml. Western Blot: ABP Antibody [NB100-56417] - Western blot analysis of ABP in (A) human brain and (B) human heart cell lysate using NB100-56417 at 1 ug/ml.