Activin A Receptor Type II-like 1 Antibody

Species: Hu Applications: WB, PEP-ELISA Clonality: Polyclonal

Gene: ACVRL1 Purity: Immunogen affinity purified Host: Goat

Specificity:	ACVRL1
Publications:	Antibody has not yet been mentioned in a publication.

Isotype:	IgG
Immunogen:	Synthetic peptide: KISNSPEKPKVIQ representing the C-Terminus of the human protein (residues 491-503) according to NP_000011.

Entrez:	94 (Human)
Swiss Prot:	NP_000011. (Human)
Related Genes:	ENG, ENG, ENG, TGFBR1, TGFBR1, SLPI, ALK, ALK, ALK, TGFB1, BMPR2, SMAD1, TGFB1, GARS, SMAD1, SMAD2, SMAD1, VEGFA, VEGFA, VEGFA, BMPR2, TNFRSF8, TNFRSF8, SMAD2, SMAD2, TNFRSF8, BMPR2, ACVR1, SMAD4, SMAD4, SMAD4, TGFBR2, TGFBR2, INHBA, GDF2, INHBB, ID1, ID1, SMAD5, MS4A1

**Please note, this product is one of a range of Investigative Grade antibodies, made against targets that have limited or no commercial antibodies available to them and for which there are no data on the expression of the protein in the range of common cell lines and tissues available to us. These antibodies are affinity purified using their peptide immunogen and are known to give low background staining in a western blot. However no additional claims are made for their ability to recognise native protein in any application. Activin A receptor, type II-like 1 is a type I cell-surface receptor for the TGF-beta superfamily of ligands. ACVRL1 is most highly expressed in human placenta and lung. ACVRL1 deficiency causes hemorrhagic telangiectasia type 2 (HHT2; MIM 600376 ) also known as Rendu-Osler-Weber syndrome 2 (ORW2).Note: ACVRL1 is also known as ALK1 - not to be confused with the similarly named ALK (anaplastic lymphoma kinase).

Reactivity:	Human.

Uses:	This antibody is useful for Peptide ELISA and Western Blot. Preliminary experiments gave no signal but low background in Human Lung and Liver extracts.
Dilutions:	Peptide ELISA 1:32000, Western Blot 1µg/ml
Concentrations:	0.5 mg/ml
Positive Controls:	1 positive controls

Buffer:	Tris saline containing [pH7.3] with 0.5% BSA
Storage:	Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Preservative:	0.02% Sodium Azide
Limitations:	This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.