Myeloperoxidase/MPO Antibody (8F4) 0.025 mg



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Ordering Information: NBP1-51148

  • Catalog Number
    NBP1-51148
  • Displayed Format
    Unconjugated
  • Other Formats
  • Size(s)
    0.025 mg
  • Availability
  • Price
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Myeloperoxidase/MPO Antibody (8F4) Summary

Species Mouse, Rat
Tested Applications Flow, IA, IHC, IHC-Fr
Clonality
Monoclonal
Host
Mouse
Gene
MPO
Purity
IgG purified
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Myeloperoxidase/MPO Antibody (8F4) Details

Clone
8F4
Isotype
IgG1
Immunogen
Purified mouse MPO from WEHI-3 cells

Species Reactivity

Please be aware that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional optimization may be required. Please contact Technical Support for more information.

Applications/Dilutions

Dilutions
  • Flow Cytometry 1:10-1:1000
  • Immunoassay
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
Positive Controls
Other Available
Formats
Biotin Labeled NBP1-51149B
FITC Labeled NBP1-79141
Publications
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NBP1-51148 in the following applications:

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    Publications

    Myeloperoxidase/MPO Antibody (NBP1-51148) has been mentioned in at least 5 publications.
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    Notes

    Positive control: Neutrophils isolated from digested infarcts Negative control: Lymphocytes isolated from digested infarcts

    Packaging, Storage & Formulations

    Storage
    Store at 4C. Do not freeze.
    Buffer
    0.2 um filtered antibody solution in PBS, containing 0.1% bovine serum albumin.
    Unit Size
    0.025 mg
    Concentration
    0.1 mg/ml
    Preservative
    0.02% Sodium Azide
    Limitations
    This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

    Bioinformatics

    Gene Symbol MPO

    Alternate Names for Myeloperoxidase/MPO Antibody (8F4)

    • EC 1.11.1
    • EC 1.11.1.7
    • myeloperoxidase

    Related Products by Gene

    Background

    The monoclonal antibody 8F4 recognizes mouse myeloperoxidase (MPO). MPO is a glycoprotein produced as a single precursor, which is subsequently cleaved into a alpha and beta chain. In human the biologically active MPO is a 150kDa tetramer composed of 2 glycosylated alfa chains of 59-64 kDa and 2 beta chains of 14 kDa. MPO is stored in azurophilic granules of polymorphonuclear leukocytes and is rapidly released into the phagosome and extracellular space during inflammatory conditions.The enzyme catalyzes the conversion of chloride and hydrogen peroxide to hypochlorite, a potent oxidant, which functions in host defense against microorganisms. Involvement of MPO has been described in several human diseases, such as cardiovascular disease, airway inflammation, lung cancer, Alzheimer's disease and multiple sclerosis. A positive correlation between elevated MPO levels in serum and cardiovascular disease suggest an interesting role for MPO as an diagnostic marker, making it possible to identify patients at risk for future cardiac events. Furthermore, there are some autoimmune diseases, in which MPO is targeted by antineutrophil cytoplasm antibodies. Studies with MPO-knockout mice have shown an increased susceptibility to pneumonia following intratracheal infections. Moreover, MPO deficient mice are more susceptible to experimental autoimmune encephalitis, a T cell-dependent neuronal disease, and have an increased expression of arteriosclerotic plaques compared to wild-type mice.

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    Publications for Myeloperoxidase/MPO Antibody (NBP1-51148) (5)

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    Product General Protocols

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    FAQs for Myeloperoxidase/MPO (2)

    1. In the immunohistochemistry paraffin section protocol....the PBS buffer....should it be at certain pH?
      • For IHC application, different labs cites the pH of PBS buffer in the range of 7.1 - 7.6 but most commonly used pH is pH 7.4 (this is what we use in our lab). You may use this PBS (pH 7.4) for making permeablization buffer, antibody diluent buffers and for making wash buffer. For more on the protocol that we use in our lab and for IHC-P troubleshooting suggestions, you may visit: IHC-P Protocol and IHC-P Troubleshooting.
    2. I was wondering what does Format 7C mean as far as anitbodies go?
      • 7C is a fluorophore - it is useful for FLOW. The details of the fluor are (A=425, E=500)

    Bioinformatics Tool for Myeloperoxidase/MPO

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