Myeloperoxidase Antibody (8F4) 0.025 mg

Myeloperoxidase NBP1-51148

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Ordering Information: NBP1-51148

Catalog NumberNBP1-51148
  • FormUnconjugated
  • Formats
  • Size(s)0.025 mg
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Myeloperoxidase Antibody (8F4) Summary

 
Species Mouse, Rat
Tested Applications FLOW, IA, IHC, IHC-Fr
Clonality Monoclonal
Host Mouse
Gene MPO
Purity IgG purified
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Myeloperoxidase Antibody (8F4) Details

 
Clone 8F4
Isotype IgG1
Immunogen Purified mouse MPO from WEHI-3 cells

Applications/Dilutions

 
Dilutions
  • Flow Cytometry 1:10-1:1000
  • Immunoassay
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
Positive Controls

1 Positive Control

Other Available
Formats
Biotin Labeled NBP1-51149B
FITC Labeled NBP1-79141
Learn about Custom Antibody Labeling

Product PDFs

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Publications

Myeloperoxidase Antibody (NBP1-51148) has been mentioned in at least 5 publications.
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Controls & Support Products

Research Tools

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Notes

 
Positive control: Neutrophils isolated from digested infarcts Negative control: Lymphocytes isolated from digested infarcts

Packaging, Storage & Formulations

 
Storage Store at 4C. Do not freeze.
Buffer 0.2 um filtered antibody solution in PBS, containing 0.1% bovine serum albumin.
Unit Size 0.025 mg
Concentration 0.1 mg/ml
Preservative 0.02% Sodium Azide
Limitations This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

 
Gene Symbol MPO

Alternate Names for Myeloperoxidase

 
  • EC 1.11.1
  • EC 1.11.1.7
  • myeloperoxidase

Related Products by Gene

Background

 
The monoclonal antibody 8F4 recognizes mouse myeloperoxidase (MPO). MPO is a glycoprotein produced as a single precursor, which is subsequently cleaved into a alpha and beta chain. In human the biologically active MPO is a 150kDa tetramer composed of 2 glycosylated alfa chains of 59-64 kDa and 2 beta chains of 14 kDa. MPO is stored in azurophilic granules of polymorphonuclear leukocytes and is rapidly released into the phagosome and extracellular space during inflammatory conditions.The enzyme catalyzes the conversion of chloride and hydrogen peroxide to hypochlorite, a potent oxidant, which functions in host defense against microorganisms. Involvement of MPO has been described in several human diseases, such as cardiovascular disease, airway inflammation, lung cancer, Alzheimer's disease and multiple sclerosis. A positive correlation between elevated MPO levels in serum and cardiovascular disease suggest an interesting role for MPO as an diagnostic marker, making it possible to identify patients at risk for future cardiac events. Furthermore, there are some autoimmune diseases, in which MPO is targeted by antineutrophil cytoplasm antibodies. Studies with MPO-knockout mice have shown an increased susceptibility to pneumonia following intratracheal infections. Moreover, MPO deficient mice are more susceptible to experimental autoimmune encephalitis, a T cell-dependent neuronal disease, and have an increased expression of arteriosclerotic plaques compared to wild-type mice.