Mre11 Antibody (NB100-276) | Novus Biologicals

Mre11 Antibody (NB100-276) (0.1 mg)

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	Catalog Number	NB100-276
	Size(s)	0.1 mg	Price:
	Availability
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anti-endo/exonuclease Mre11 antibody, anti-MRE11 homolog 1 antibody, anti-double-strand break repair protein MRE11A antibody, anti-HNGS1 antibody, anti-DNA recombination and repair protein antibody, anti-Meiotic recombination 11 homolog A antibody, anti-AT-like disease antibody, anti-Meiotic recombination 11 homolog 1 antibody, anti-MRE11MRE11B antibody, anti-ATLDmeiotic recombination (S. cerevisiae) 11 homolog A antibody, anti-MRE11 homolog A antibody, anti-MRE11 meiotic recombination 11 homolog A (S. cerevisiae) antibody

Mre11 Antibody Summary:

Species:	Hu	Gene:	MRE11A
Applications:	WB, IHC-P	Purity:	Affinity purified
Clonality:	Polyclonal	Host:	Rabbit
Specificity:	This is specific for human Mre11.
Publications:

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Lysates	Peptides and Proteins
Primary Antibodies	RNAi
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Mre11 Antibody Details:

Immunogen:	The epitope recognized by this antibody maps to a region between residues 1 and 50 of human Meiotic Recombination 11 homolog A using the numbering given in entry NP_005582.1 (GeneID 4361).

Species Reactivity:

Human Mre11. Reactivity with Mouse and Rat is likely (28/30 residues of the peptide used for immunogen are identical to Mouse and Rat Mre11).

Applications:

Uses:	This antibody works in Immunohistochemistry-Paraffin and Western blot.
Dilutions:	Immunohistochemistry-Paraffin, Western Blot
Unit Size:	0.1 mg
Concentration:	1.0 mg/ml
Positive Controls:	2 Positive Controls

Packaging:

Storage:	Store at 4°C. Do not freeze.
Buffer:	Tris-citrate/phosphate buffer, pH 7 to 8
Preservative:	0.1% Sodium Azide
Limitations:	This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.

Gene Symbol: MRE11A

Entrez:	4361 (Human)
Uniprot:	NP_005582.1 (Human)

Related Genes:

Background:

The hMre11-hRad50-NBS1 protein plays a central role in the human cellular DNA-Damage response, with recent studies indicating that these proteins help link DNA-damage detection to DNA-repair and cell cycle-checkpoint functions (1). This protein complex has been implicated in the activation of cell cycle-regulatory pathways, due to the fact that the NBS1 gene mutates in the chromosomal-instability syndrome, Nijmegen breakdown syndrome (NBS), which is characterized by increased cancer incidence, cell cycle checkpoint defects, and ionizing radiation sensitivity

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Mre11 Antibody Images (2)

	Western Blot: Mre11 Antibody [NB100-276] - Samples: Whole cell lysate from HeLa cells. Antibodies: Affinity purified rabbit anti-Mre11 antibody used for WB at 0.1 mcg/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.

	Immunohistochemistry-Paraffin: Mre11 Antibody [NB100-276] - FFPE section of human basal cell carcinoma. Affinity purified rabbit anti-Mre11 used at a dilution of 1:250. Detection: DAB staining using Immunohistochemistry Accessory Kit