MTH1 Antibody 0.2 ml

MTH1 NB100-109

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Ordering Information: NB100-109

Catalog NumberNB100-109
  • FormUnconjugated
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MTH1 Antibody Summary

 
Species Human, Mouse, Rat
Tested Applications WB, ICC/IF, IHC, IHC-Fr, IHC-P
Clonality Polyclonal
Host Rabbit
Gene NUDT1
Purity Immunogen affinity purified
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MTH1 Antibody Details

 
Immunogen A C-terminal peptide derived from human MTH1, conjugated to KLH. [UniProt# P36639]

Species Reactivity

 
Human, Mouse and Rat.
Publications Read Publications using NB100-109 in the following species:
 

Applications/Dilutions

 
Dilutions
  • Western Blot 1:500
  • Immunocytochemistry/Immunofluorescence 1:50-1:200
  • Immunohistochemistry 1:200
  • Immunohistochemistry-Frozen 1:200
  • Immunohistochemistry-Paraffin
Application Notes

This MTH1 antibody is useful for Western blot, Immunocytochemistry/Immunofluorescence and Immunohistochemistry on frozen sections. In WB, a band can be seen at ~18kDa.

Molecular Weight

18 kDa

Positive Controls

2 Positive Controls

Other Available
Formats
Alexa Fluor (R) 405 Labeled NB100-109AF405
Alexa Fluor (R) 488 Labeled NB100-109AF488
Alexa Fluor (R) 647 Labeled NB100-109AF647
Alexa Fluor (R) 700 Labeled NB100-109AF700
Biotin Labeled NB100-109B
DyLight 405 Labeled NB100-109V
DyLight 488 Labeled NB100-109G
DyLight 550 Labeled NB100-109R
DyLight 650 Labeled NB100-109C
FITC Labeled NB100-109F
HRP Labeled NB100-109H
Learn about Custom Antibody Labeling
Publications
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NB100-109 in the following applications:

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Publications

MTH1 Antibody (NB100-109) has been mentioned in at least 7 publications.
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Protocols and FAQs

Controls & Support Products

Research Tools

View all MTH1 Research Tools.

Packaging, Storage & Formulations

 
Storage Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer PBS
Unit Size 0.2 ml (also available in 0.05 ml (sample size))
Concentration 1.0 mg/ml
Preservative 0.05% Sodium Azide
Limitations This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

 
Gene Symbol NUDT1
Entrez
Uniprot

Alternate Names for MTH1

 
  • 8-oxo-7,8-dihydrodeoxyguanosine triphosphatase
  • EC 3.6.1.-
  • nucleoside diphosphate-linked moiety X-type motif 17,8-dihydro-8-oxoguanine triphosphatase
  • mutT human homolog 1,8-oxo-dGTPase
  • Nudix motif 1
  • MTH1Nucleoside diphosphate-linked moiety X motif 1
  • nudix (nucleoside diphosphate linked moiety X)-type motif 1,8-oxo-7,8-dihydroguanosine triphosphatase

Related Products by Gene

Background

 
MTH1 (human MutT Homolog 1) is an oxidized purine nucleoside triphosphatase enzyme that belongs to the Nudix hydrolase family and it acts as major mammalian detoxifier of the oxidized DNA precursor, 8-oxo-dGTP thereby exerting antimutagenic effects and suppressing cell dysfunction/death induced by oxidative stress. MTH1 hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thereby preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. MTH1 also hydrolyzes the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP. 2-OH-dADP, 8-OH-dGDP and 8-OH-dGTP inhibit the 2-OH-dATPase activity whereas 8-OH-dGTPase activity is inhibited by 8-OH-dGDP, 2-OH-dADP and 2-OH-dATP. Localized mainly in the cytoplasm, MTH1 has been found in nucleus and mitochondria also, and is widely expressed with highest expression in thymus, testis, embryo, proliferating blood lymphocytes etc. Oxidative DNA damage, e.g. 8-oxoG is known to accumulate both in nuclear and mitochondrial genomes during aging, carcinogenesis or various neurodegenerative diseases, such as Parkinson's disease, Alzheimer's disease or amyotrophic lateral sclerosis and MTH1 deficiency can increase susceptibility to these oxidative damage mediated dysfunctions.