MSH2 Antibody (EPR3943) (NBP1-40818)

MSH2 Antibody (EPR3943) (NBP1-40818) (0.1 ml)

Additional Products Available View our MSH2 products. Call 303-730-1950 for recommended products	Ordering Information:
	Catalog Number	NBP1-40818
	Size(s)	0.1 ml	Price:
	Availability
Why Choose Novus?	Bulk Quote
	View All MSH2 Primary Antibodies

anti-COCA1 antibody, anti-DNA mismatch repair protein Msh2 antibody, anti-hMSH2 antibody, anti-MutS protein homolog 2 antibody, anti-LCFS2 antibody, anti-HNPCC antibody, anti-HNPCC1mutS (E. coli) homolog 2 (colon cancer, nonpolyposis type 1) antibody, anti-FCC1 antibody, anti-mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) antibody

MSH2 Antibody (EPR3943) Summary:

Species:	Hu	Gene:	MSH2
Applications:	WB, FACS, IHC (-)	Purity:	IgG purified
Clonality:	Monoclonal	Host:	Rabbit
Publications:

View Additional MSH2 Products

Lysates	Peptides and Proteins
Primary Antibodies	RNAi
» View All MSH2 Related Products

MSH2 Antibody (EPR3943) Details:

Clone:	EPR3943
Isotype:	IgG
Immunogen:	A synthetic peptide corresponding to residues on the N-terminus in human MSH2 was used as an immunogen.

Species Reactivity:

Reacts in Human.

Applications:

Uses:	Due to non-specific staining using this antibody on human tissue, this antibody is not recommended for IHC usage. In Western blot this antibody detects a band at approximately 100kDa.
Dilutions:	Flow Cytometry 1 : 10-100, Immunohistochemistry (-), Western Blot 1 : 1000-10000
MW:	100 kDa
Unit Size:	0.1 ml
Concentration:	Please see the vial label for concentration.

Packaging:

Storage:	Store at -20°C. Avoid freeze-thaw cycles.
Buffer:	50mM Tris-Glycine [pH 7.4] containing 0.15M NaCl, 40% Glycerol and 0.05% BSA
Preservative:	0.01% Sodium Azide
Limitations:	This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.

Gene Symbol: MSH2

Uniprot:	P43246 (Human)

Related Genes:

Background:

MSH2 is a 100 kDa nuclear antigen and encodes a protein of 934 amino acids. The MSH2 gene is one of 4 known genes encoding proteins involved in the rapair of mismatch nucleotides following DNA replications or repair. Mutations in the NSH2 gene contribute to the development of sporadic colorectal carcinoma. MSHS mutations are responsible for 50% of inherited non-polyposis colorectal (HNPCC). The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. MSH-2 is involved in the intial cognition of mismatch nucleotides during the replication mismatch repair process.

Images (2)


View All Images...

Be the first to review this product for a reward!

Review this product now.

MSH2 Antibody (EPR3943) Images (2)

	Western Blot: MSH2 Antibody (EPR3943) [NBP1-40818] - Western blot analysis on (A) A375, (B) A431, (C) SW480, and (D) HeLa cell lysates using anti-MSH2

	Western Blot: MSH2 Antibody (EPR3943) [NBP1-40818] - (A) MSH2 positive cell line SW480 and (B) MSH2 negative cell line LOVO. Note: distinct band on positive cell line and no specific band on negative cell line.