MSH2 Antibody (A00799.01) (NBP1-49261)

MSH2 Antibody (A00799.01) (NBP1-49261) (40 ug)

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	Catalog Number	NBP1-49261
	Size(s)	40 ug	Price: N/A
	Availability	Discontinued
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anti-COCA1 antibody, anti-DNA mismatch repair protein Msh2 antibody, anti-hMSH2 antibody, anti-MutS protein homolog 2 antibody, anti-LCFS2 antibody, anti-HNPCC antibody, anti-HNPCC1mutS (E. coli) homolog 2 (colon cancer, nonpolyposis type 1) antibody, anti-FCC1 antibody, anti-mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) antibody

MSH2 Antibody (A00799.01) Summary:

Species:	Hu	Gene:	MSH2
Applications:	WB, ELISA, IHC-Fr, IHC-P	Purity:	Protein G purified
Clonality:	Monoclonal	Host:	Mouse
Specificity:	A431 cell lysate (WB) human MSH2 recombinant protein (ELISA) human rectum carcinoma tissue (IHC)
Publications:

View Additional MSH2 Products

Lysates	Peptides and Proteins
Primary Antibodies	RNAi
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MSH2 Antibody (A00799.01) Details:

Clone:	A00799.01
Isotype:	IgG1
Immunogen:	Ni-NTA purified recombinant human MSH2 expressed in E. coli strain BL21 (DE3)

Species Reactivity:

Human

Applications:

Uses:	This antibody is useful in Western Blot, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, ELISA.
Dilutions:	Western Blot 1:200-1:1000, Immunohistochemistry-Paraffin 1:200-1:1000, Immunohistochemistry-Frozen 1:200-1:1000, ELISA 1:10000
Unit Size:	40 ug
Concentration:	1.0 mg/ml

Packaging:

Storage:	Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
Buffer:	10mm PBS, pH 7.6
Preservative:	0.02% Sodium Azide
Limitations:	This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.

Gene Symbol: MSH2

Related Genes:

Background:

MSH2 is a 100 kDa nuclear antigen and encodes a protein of 934 amino acids. The MSH2 gene is one of 4 known genes encoding proteins involved in the rapair of mismatch nucleotides following DNA replications or repair. Mutations in the NSH2 gene contribute to the development of sporadic colorectal carcinoma. MSHS mutations are responsible for 50% of inherited non-polyposis colorectal (HNPCC). The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. MSH-2 is involved in the intial cognition of mismatch nucleotides during the replication mismatch repair process.

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MSH2 Antibody (A00799.01) Images (2)

	Western Blot: MSH2 Antibody (A00799.01) [NBP1-49261]

	Immunohistochemistry: MSH2 Antibody (A00799.01) [NBP1-49261] - Immunohistochemical analysis of paraffin-embedded human rectum carcinoma tissue showing nuclear and cytoplasmic localization using Mouse Anti-MSH2 Monoclonal Antibody with DAB staining.