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MEKK3 Antibody

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Product Details

Summary
Product Discontinued
View other related MEKK3 Primary Antibodies

Order Details


    • Catalog Number
      NBP1-68134
    • Availability
      Product Discontinued

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MEKK3 Antibody Summary

Immunogen
The antiserum was produced against synthesized peptide derived from human MAP3K3. The immunogen region is: Internal.
Specificity
MAP3K3 Antibody detects endogenous levels of total MAP3K3 protein.
Clonality
Polyclonal
Host
Rabbit
Gene
MAP3K3
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • ELISA 1:20000
  • Western Blot 1:500-1:1000

Reactivity Notes

Human,Mouse

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
PBS (without Mg2+ and Ca2+, pH 7.4), 0.15M NaCl and 50% Glycerol
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for MEKK3 Antibody

  • EC 2.7.11.25
  • MAP/ERK kinase kinase 3
  • MAP3K3
  • MAPK/ERK kinase kinase 3
  • MAPKKK3
  • MAPKKK3MEKK 3
  • MEK kinase 3
  • MEKK3
  • mitogen-activated protein kinase kinase kinase 3

Background

MEKK3 is a Ser/Thr protein kinase belonging to the MAP/ERK kinase kinase family (1). Closely related to MEKK2, MEKK3 is expressed in a multitude of tissues. MEKK3 directly regulates SAPKs and ERKs pathway via SEK and MEK1, respectively but not the p38 pathway (2) and is also involved in the NF-kB pathway (3). MEKK3 as well as MEKK2 bind, phosphorylate and activate MEK5 through their PB1 domain (4). hKSR-2 (human kinase suppressor of ras-2) has been shown to regulate the activity of MEKK3 (5).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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MEKK3 Antibody
NBP1-68134
MEKK3 Antibody
Species: Hu, Mu
Applications: WB, ELISA

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Bioinformatics

Gene Symbol MAP3K3
Uniprot