MDR1 Antibody (NBP1-19787)
MDR1 Antibody
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Distributor Data...
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anti-ABCB1 antibody, anti-PGY1 antibody, anti-P-GP antibody, anti-MDR1 antibody, anti-GP170 antibody, anti-EC 3.6.3.44 antibody, anti-CLCS antibody, anti-CD243 antibody, anti-ABC20 antibody, |
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MDR1 Antibody Summary: | | Gene: | ABCB1 |
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| Purity: | Affinity purified |
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| Host: | Rabbit |
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| | | Note: Not all species have been tested for usefulness with this product. Only those species listed have been tested. We cannot make any guarantees about additional reactivities which may or may not occur. |
View Additional MDR1 Products MDR1 Antibody Details: | Immunogen: | Synthetic peptide corresponing to the residues surrounding Isoleucine 583 of human Mdr-1 |
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| Uses: | This antibody is useful for Immunohistochemistry analysis of Mdr-1 (I583) antibody in paraffin-embedded human brain tissue. Customers have also reported successful IF staining using this antibody. Purity is > 95% (by SDS-PAGE). |
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| Dilutions: | Immunofluorescence 1:100, Immunohistochemistry-Paraffin 1:50-1:200 |
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| Unit Size: | 0.1 mg |
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| Concentration: | 1.0 mg/ml |
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Packaging: | Storage: | Store at 4 °C short term. Aliquot and store at -20 °C long term. Avoid freeze-thaw cycles. |
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| Buffer: | Phosphate buffered saline (PBS), approx. pH 7.2. |
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| Preservative: | 0.05% Sodium Azide |
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| Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. |
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Background: Cells selected for resistance to a single cytotoxic drug may become crossresistant
to a broad range of drugs with different structures and cellular
targets. This phenomenon is called multiple drug resistance (MDR). The
MDR proteins (Mdrs) are members of a highly conserved superfamily of ATPbinding
cassette transport proteins. Mdr functions as an energy-dependent
efflux pump for structurally diverse agents ranging from ions to peptides. It is
implicated in the development of the multiple drug resistance observed in
human cancer cells following prolonged chemotherapy. The classic form of
MDR is associated with an increase in the Mdr protein, but not all cases of
MDR can be attributed to a rise in Mdr levels. Mdr-1 is an apical transmembrane
protein that is an integral part of the blood-brain barrier and functions
as a drug-transport pump transporting a variety of drugs from the brain back
into the blood. In the human population, there are 15 polymorphisms in the
Mdr-1 gene.
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Images (2) Reviews (1) Related Products (18) Exploring MDR1 Working with MDR1
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Jump to: Images, Reviews, Ask a Question
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Working with MDR1
MDR1 Antibody Images (2) Immunofluorescence: P Glycoprotein Antibody [NBP1-19787] - IF staining of frozen human tumor tissues. Data submitted by Chia-Hung Hsieh and Chien-Yi Chiang from the Graduate Institute of Basic Medical Science , China Medical University. |  Immunohistochemistry: Mdr-1 Antibody [NBP1-19787] - Mdr-1 Antibody [NBP1-19787] - paraffin-embedded human brain tissue. |
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Reviewed by:
Chia-Hung Hsieh 12/28/2011
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Application:
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IHC-P
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Sample Tested:
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Human Brain Tissue
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Species:
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Human
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Species Other:
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Also tested mouse
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Sample Pretreatment:
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Formaldehyde
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Results:
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The signal is strong and clear for both human brain tissue and mouse tissue.
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Dilution Ratio:
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100x dilution
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Incubation Time:
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1hr
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Incubation Temperature:
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RT RT
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Description:
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Goat anti-rabbit IgG Dylight 649
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Visualization Method:
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Image Quant, Confocul Microscopy
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Ask a Scientist
Can't find an answer to your question about MDR1? Ask us by using live
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Jump to: Peptides and Proteins, Primary Antibodies, RNAi, Secondary Antibodies
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Related ProductsPeptides and ProteinsPrimary Antibodies (10)| Name | Catalog# | Reactivity | Applications | Images | Publications | Reviews | |
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| MDR1 Antibody (C219) | NB600-1036 | Ca, Hu, Mk, Mu, Rt | ICC, IHC-Fr, IHC-P, IP, WB | | (6) | | | | MDR1 Antibody (PG-13) | NBP1-42581 | Hu | ICC, IF, IHC-Fr, IHC-P, IP, WB | | | | | | MDR1 Antibody (JSB-1) | NBP1-51768 | Ha, Mu(-), Rt(-) | FACS, IHC-Fr, IHC-P, WB | | | | | | MDR1 Antibody | NBP1-90291 | Hu | IF, IHC-P, WB | (1) | | | | | MDR1 Antibody | NB100-80870 | Ca, Hu, Mk, Mu(-), Rt | ELISA, IHC-P, WB | (1) | | | | | ... and 5 more. See All » |
RNAi (1)Secondary Antibodies| Name | Catalog# | Reactivity | Applications | Images | Publications | Reviews | |
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| Rabbit IgG Antibody [HRP] | NB730-H | Rb | ELISA, ICC, IHC-P, WB | | (5) | | | | Rabbit IgG Antibody [FITC] | NB730-F | Rb | ICC, IHC-P | | (1) | | | | Rabbit IgG Antibody [Biotin] | NB730-B | Rb | ELISA, ICC, IHC-P, WB | | | | | | Rabbit IgG, H/L Chains Antibody [DyLight 488] | NBP1-72944 | Rb | FLISA, IF, WB | (3) | | | | | Rabbit IgG Antibody [Alkaline Phosphatase] | NB730-AP | Rb | ELISA, ICC, IHC-P, WB | | (1) | | | | See All » |
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