MDR1 Antibody (NBP1-42581)

MDR1 Antibody (PG-13)

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MDR1 Antibody (PG-13) Summary:
Species:Hu
Applications:ICC, IF, IHC-Fr, IHC-P, IP, WB
Clonality:Monoclonal
Gene:ABCB1
Purity:Affinity purified
Host:Mouse
 
 
Note: Not all species have been tested for usefulness with this product. Only those species listed have been tested. We cannot make any guarantees about additional reactivities which may or may not occur.
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MDR1 Antibody (PG-13) Details:
Clone:PG-13
Isotype:IgG1
Immunogen:A mixture of human and hamster drug-resistant whole cells and crude plasma membranes.
Species Reactivity:

Human

Applications:
Uses:This antibody is useful in Western Blot, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Immunoprecipitation, Immunofluorescence and Immunocytochemistry.
Dilutions:Immunocytochemistry, Immunofluorescence, Immunohistochemistry-Frozen 1-2ug/ml, Immunohistochemistry-Paraffin 1-2ug/ml, Immunoprecipitation, Western Blot 0.5-1ug/ml
Unit Size:0.1 mg
Concentration:Lyoph
Packaging:
Storage:Store at 4 °C short term. Aliquot and store at -20 °C long term. Avoid freeze-thaw cycles.
Buffer:Lyophilized from 1.2% sodium acetate, with 2mg BSA Add diH20 for desired concentration.
Preservative:No Preservative
Limitations:This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.
Gene Symbol: ABCB1
 
Background:

P Glycoprotein, the product of the MDR1 gene, is expressed in distinct non-malignant cells, typically cells with secretory and excretory functions. It is assumed to function as an ATP-dependent drug efflux pump with broad substrate specificity. The highest expression of P Glycoprotein has been observed in kidney (proximal tubules), liver (bile canaliculi), adrenal gland and intestine, suggesting that the primary role of P Glycoprotein is in the normal secretion of physiological metabolites and ingested chemicals into bile, urine and the lumen of the intestinal tract. Elevated levels of P Glycoprotein have also been reported in multidrug-resistant cell lines and in colon, endometrial, ovarian, and breast tumors, as well as in sarcomas and leukemias / lymphomas.

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