MDR1 Antibody (H00005243-M01)

MDR1 Antibody (1F11)

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MDR1 Antibody (1F11) Summary:
Species:Hu
Applications:ELISA, WB
Clonality:Monoclonal
Gene:ABCB1
Purity:IgG purified
Host:Mouse
Specificity:ABCB1 - ATP-binding cassette, sub-family B (MDR/TAP), member 1
 
Note: Not all species have been tested for usefulness with this product. Only those species listed have been tested. We cannot make any guarantees about additional reactivities which may or may not occur.
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MDR1 Antibody (1F11) Details:
Clone:1F11
Isotype:IgG1 Kappa
Immunogen:ABCB1 (NP_000918, 620 a.a. ~ 710 a.a) partial recombinant protein with GST tag.
Epitope:GIYFKLVTMQTAGNEVELENAADESKSEID ALEMSSNDSRSSLIRKRSTRRSVRGSQAQD RKLSTKEALDESIPPVSFWRIMKLNLTEWP *
Species Reactivity:

Human. Other species not tested.

Applications:
Uses:Antibody Reactive against Recombinant Protein with GST tag on ELISA and Western Blot. GST tag alone is used as a negative control.
Dilutions:ELISA, Western Blot 1:500
Unit Size:0.1 mg
Concentration:Please see the vial label for concentration.
Notes:
This product is produced by and distributed for Abnova, a company based in Taiwan.
Packaging:
Storage:Aliquot and store at -20 °C or -80 °C. Avoid freeze-thaw cycles.
Buffer:In 1x PBS, pH 7.2
Preservative:No Preservative
Limitations:This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.
Gene Symbol: ABCB1
Entrez5243 (Human)
OMIM171050 (Human)
Swiss ProtNP_000918 (Human)
 
Background:

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.

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Jump to: Peptides and Proteins, Primary Antibodies, RNAi, Secondary Antibodies

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