MCP1 Antibody (20530002) | Novus Biologicals

MCP1 Antibody (20530002) (0.05 mg)

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	Catalog Number	20530002
	Size(s)	0.05 mg	Price:
	Availability
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anti-small inducible cytokine A2 (monocyte chemotactic protein 1, homologous tomouse Sig-je) antibody, anti-small inducible cytokine subfamily A (Cys-Cys), member 2 antibody, anti-SMC-CF antibody, anti-monocyte chemoattractant protein-1 antibody, anti-MGC9434 antibody, anti-C-C motif chemokine 2 antibody, anti-GDCF-2 antibody, anti-SCYA2HSMCR30 antibody, anti-MCP-1Small-inducible cytokine A2 antibody, anti-HC11Monocyte secretory protein JE antibody, anti-MCP1Monocyte chemotactic protein 1 antibody, anti-MCAFMonocyte chemotactic and activating factor antibody, anti-Monocyte chemoattractant protein 1 antibody, anti-chemokine (C-C motif) ligand 2 antibody

MCP1 Antibody Summary:

Species:	Hu	Gene:	CCL2
Applications:	ELISA, IHC-P	Purity:	Affinity purified
Clonality:	Polyclonal	Host:	Rabbit
Specificity:	This product is specific for Human CCL2.
Publications:

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MCP1 Antibody Details:

Immunogen:	This antibody is specific for the entire range of the target protein.

Species Reactivity:

Human.

Applications:

Uses:	This antibody is useful in ELISA and Immunohistochemistry-Paraffin.
Dilutions:	ELISA, Immunohistochemistry-Paraffin
Unit Size:	0.05 mg
Concentration:	Please see the vial label for concentration.

Notes:

Manufactured by SDIX's proprietary Genomic Antibody Technology™. GAT FAQs.

Packaging:

Storage:	Store at -20°C. Avoid freeze-thaw cycles.
Buffer:	20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0
Preservative:	No Preservative
Limitations:	This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.

Gene Symbol: CCL2

Uniprot:	NM_002982 (Human)

Related Genes:

Background:

Monocyte chemoattractant protein-1 (MCP-1) is a member of the chemokine-beta family of cytokines. The protein is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. It may play a inprotant role in the initiation and/or progression of pulmonary hypertension (PH). Blockade of a systemic MCP-1 signal pathway in vivo may prevent PH.

Images (2)


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MCP1 Antibody Images (2)

	Immunohistochemistry: MCP1 Antibody [20530002] - Strong cytoplasmic positivity with additional staining of luminal membranes was seen in mucus-producing cells of the gastro-intestinal tract. Cells of the CNS and lymphoid tissues were in general negative, except for mast cells, which were strongly positive. In malignant tissues, mucin secreting colo-rectal carcinomas and mucinous cystadenocarcinomas of ovary exhibited strong cytoplasmic staining with additional positivity of luminal membranes. Few other adenocarcinomas were strongly stained in cytoplasm. Malignant gliomas, lymphomas and renal cancers were mainly negative. Image and statement courtesy of the Human Protein Atlas (HPA).

	ELISA: MCP1 Antibody [20530002]