MAG/Siglec-4a Antibody (EP971Y)

Produced using Abcam's RabMab® technology. RabMab® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

Myelin-associated glycoprotein (MAG), a membrane glycoprotein of 100 kDa, is thought to be involved in the process of myelination (1). Axonal regeneration in the adult central nervous system (CNS) is limited by two proteins in myelin, Nogo and MAG (2). MAG has been implicated in inhibition of nerve regeneration in the CNS. This results from interactions between MAG and the Nogo receptor and gangliosides on the apposing axon, which generates intracellular inhibitory signals in the neuron (3). Results also suggest that MAG binds to a specific receptor and initiates a signal transduction cascade to effect inhibition. These results indicate that soluble dMAG detected in vivo could contribute to the lack of regeneration in the mammalian CNS after injury (4).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Images	Ratings	Applications	Species	Date	Details
	4 reviewed by: Sandra Canosa	WB	Mouse	06/15/2010	View Summary Application Western Blot Sample Tested Mouse neural stem cells lysate and whole embryo (E8.5) homogenate, Sample Amount: 15 ug Species Mouse Lot YD070601

Array NB110-57177

• MAG/Siglec-4a Antibodies
• MAG/Siglec-4a ELISA Kit
• MAG/Siglec-4a Lysate
• MAG/Siglec-4a Protein
• MAG/Siglec-4a Proteins and Enzymes