Lipoprotein Lipase/LPL Antibody Summary
| Immunogen |
A synthetic peptide (EKVSHLQKGKAPAVFVKCHDKSL) corresponding to a region (448-470 aa) from the C-terminus of human Lipoprotein lipase (LPL). |
| Specificity |
The specificity of this antibody has been confirmed by WB against the antigen. |
| Clonality |
Polyclonal |
| Host |
Rabbit |
| Gene |
LPL |
| Purity |
Immunogen affinity purified |
| Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
| Dilutions |
|
| Application Notes |
Western Blot. A concentration of 1.0 ug/ml is recommended for WB. Human LPL (precursor) has a predicted length of 475 amino acids and MW of 53 kDa. |
Reactivity Notes
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Buffer |
0.2 mg DiSodium Phosphate, 0.9 mg NaCl and 5 mg BSA |
| Preservative |
0.05mg Sodium Azide |
| Concentration |
LYOPH |
| Purity |
Immunogen affinity purified |
| Reconstitution Instructions |
Reconstitute with 0.1 ml sterilized distilled water to a final concentration of 1.0 mg/ml. Centrifuge to remove any insoluble material. |
Alternate Names for Lipoprotein Lipase/LPL Antibody
Background
LPL, also known as Lipoprotein lipase, is a 475 amino acid that is 53 kDa, is a vascular lipase, but not synthesized in endothelial cells. It is anchored to the capillary endothelium by proteoglycans and acts as a catalyzer of triglycerides hydrolysis to release free fatty acids into the circulation and initiates the processing of triglyceride-rich lipoproteins such as chylomicrons and VLDL. It is being studied for its involvement in 150+ diseases and disorders including high density lipoprotein cholesterol level qtl 11, hyperlipoproteinemia, lipoprotein lipase deficiency, familial lipoprotein lipase deficiency, hyperlipoproteinemia type v, lipase deficiency combined, hyperlipoproteinemia type iii, glycogen storage disease, hyperlipidemia, hypertriglyceridemia, glucose intolerance, cetp deficiency, hypertension, fatty liver, nephrotic syndrome, kidney failure, and myocardial infarction. This protein has been shown to interact with 50 proteins including COPS6, PTPN4, RPL18A, ASCC2, KIAA1377 in developmental biology, transcriptional regulation of white adipocyte differentiation, lipid digestion, mobilization, and transport, metabolism, lipoprotein metabolism, glycerolipid metabolism, PPAR signaling pathway, and Alzheimer's disease pathways.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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