Lck Antibody (Y123) (NB110-57284)

Lck Antibody (Y123) (NB110-57284) ( 0.1 ml)

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	Catalog Number	NB110-57284
	Size(s)	0.1 ml	Price:
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anti-EC 2.7.10 antibody, anti-YT16 antibody, anti-Proto-oncogene Lck antibody, anti-Protein YT16 antibody, anti-p56-LCK antibody, anti-tyrosine-protein kinase Lck antibody, anti-EC 2.7.10.2 antibody, anti-T-lymphocyte specific protein tyrosine kinase p56lck antibody, anti-LSK antibody, anti-proto-oncogene tyrosine-protein kinase LCK antibody, anti-T cell-specific protein-tyrosine kinase antibody, anti-pp58lck antibody, anti-Lymphocyte cell-specific protein-tyrosine kinase antibody, anti-p56lck antibody, anti-Leukocyte C-terminal Src kinase antibody, anti-p56(LSTRA) protein-tyrosine kinase antibody, anti-lymphocyte-specific protein tyrosine kinase antibody

Lck Antibody (Y123) Summary:

Species:	Hu	Gene:	LCK
Applications:	WB, FACS, ICC, IHC-P, IP	Purity:	IgG purified
Clonality:	Monoclonal	Host:	Rabbit
Specificity:	The antibody does not cross-react with other SRC family member.
Publications:	NB110-57284 has at least 1 Background Reference

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Lck Antibody (Y123) Details:

Clone:	Y123
Isotype:	IgG
Immunogen:	A synthetic peptide corresponding to residues before SH3 domain of human Lck was used as immunogen.

Species Reactivity:

Human. Cross reactivity determined by Western Blot only.

Applications:

Uses:	This product is useful for: Western Blot, Immunohistochemistry-Paraffin, Immunocytochemistry, Immunoprecipitation, Flow Cytometry. In Western blot this antibody detects a band at approximately 56kDa.
Dilutions:	Western Blot 1:1000, Immunohistochemistry-Paraffin 1:250-500, Immunocytochemistry 1:100, Immunoprecipitation 1:200, Flow Cytometry 1:20
Unit Size:	0.1 ml
Concentration:	Please see the vial label for concentration.
Positive Controls:	1 Positive Controls

Packaging:

Storage:	Store at -20°C. Avoid freeze-thaw cycles.
Buffer:	50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA.
Preservative:	0.01% Sodium Azide
Limitations:	This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.

Gene Symbol: LCK

Entrez:	3932 (Human)
	16818 (Mouse)
	313050 (Rat)
Uniprot:	P06239 (Human)

Related Genes:

Background:

The human T-cell or lymphocyte specific gene Lck/p56 is a member of the Src family of non-receptors tyrosine kinase. Mostly expressed in T cells, Lck has been shown to be critical for the normal development of T lymphocytes (1). Additionally, the N-terminal region of the tyrosine kinase Lck interacts with the cytoplasmic domains of CD4 and CD8 (2). Autophosphorylation at Tyr-394 appears to be required for maximum catalytic activity (3) but it can also be suppressed by phosphorylation of the carboxyl-terminal tyrosine Tyr-505 (4).

Images (2)


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Lck Antibody (Y123) Images (2)

	Western Blot: Lck/p56 Antibody (Y123) [NB110-57284] - Western blot analysis on Jurkat cell lysate using anti-Lck/p56 (catalog #110-57284), dilution 1:1,000.

	Immunohistochemistry: Lck/p56 Antibody (Y123) [NB110-57284] - Immunohistochemical analysis of paraffin-embedded human lymphoma using anti-Lck/p56 (catalog #110-57284).