Lamin B Receptor Antibody (E398L)

Produced using Abcam's RabMab® technology. RabMab® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

Lamins are nuclear membrane proteins that serve to maintain specific cellular functions, such as DNA replication and chromatin organization (1). Lamin B receptor (LBR) is an integral protein of the nuclear envelope inner membrane. It is phosphorylated by CDC2 protein kinase in mitosis when the inner nuclear membrane breaks down into vesicles that dissociate from the lamina and the chromatin. It is phosphorylated by different protein kinases in interphase when the membrane is associated with these structures (2). The cleavage of lamins results in nuclear disregulation and cell death (3,4).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 applications: EM, ICC/IF, WB.

Showing Publications 1 - 7 of 7.

Publications using NB110-56894	Applications	Species
Funakoshi T, Clever M, Watanabe A et al. Localization of Pom121 to the inner nuclear membrane is required for an early step of interphase nuclear pore complex assembly. Mol Biol Cell 2011-04-01 [PMID: 21289085] (WB)	WB
Barrowman J, Hamblet C, George CM et al. Analysis of prelamin A biogenesis reveals the nucleus to be a CaaX processing compartment. Mol Biol Cell 2008-12-01 [PMID: 18923140] (ICC/IF)	ICC/IF
Geiger SK, B,r H, Ehlermann P et al. Incomplete nonsense-mediated decay of mutant lamin A/C mRNA provokes dilated cardiomyopathy and ventricular tachycardia. J Mol Med (Berl) 2008-03-01 [PMID: 17987279] (ICC/IF)	ICC/IF
Chi YH, Haller K, Peloponese JM Jr et al. Histone acetyltransferase hALP and nuclear membrane protein hsSUN1 function in de-condensation of mitotic chromosomes. J Biol Chem 2007-09-01 [PMID: 17631499] (ICC/IF)	ICC/IF
Fuchs TA, Abed U, Goosmann C et al. Novel cell death program leads to neutrophil extracellular traps. J Cell Biol 2007-01-01 [PMID: 17210947] (EM)	EM
Ulbert S, Antonin W, Platani M et al. The inner nuclear membrane protein Lem2 is critical for normal nuclear envelope morphology. FEBS Lett 2006-11-01 [PMID: 17097643] (ICC/IF)	ICC/IF
Maeshima K, Yahata K, Sasaki Y et al. Cell-cycle-dependent dynamics of nuclear pores: pore-free islands and lamins. J Cell Sci. [PMID: 17074834] (ICC/IF)	ICC/IF

Array NB110-56894

• Lamin B Receptor Antibodies
• Lamin B Receptor Lysates
• Lamin B Receptor Proteins