Lamin B Receptor Antibody (NB110-56894)
Lamin B Receptor Antibody (E398L)
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anti-DHCR14B antibody, anti-PRO0650 antibody, anti-PHA antibody, anti-MGC9041 antibody, anti-LMN2R antibody, anti-LMN 2R antibody, anti-LBR antibody, anti-Integral nuclear envelope inner membrane protein antibody, anti-DHCR14B antibody, anti-DHCR 14B antibody, |
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Lamin B Receptor Antibody (E398L) Summary: | | Gene: | LBR |
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| Purity: | Affinity purified |
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| Host: | Rabbit |
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| | | Note: Not all species have been tested for usefulness with this product. Only those species listed have been tested. We cannot make any guarantees about additional reactivities which may or may not occur. |
View Additional Lamin B Receptor Products Lamin B Receptor Antibody (E398L) Details: | Clone: | E398L |
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| Isotype: | IgG |
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| Immunogen: | A synthetic peptide corresponding to residues of human Lamin B Receptor was used as immunogen. |
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Reacts in Human, Rat. Does not react to Mouse. |
| Uses: | This product is useful for: Western Blot, Immunocytochemistry, Immunoprecipitation. In Western blot this antibody detects a band at approximately 71kDa. |
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| Dilutions: | Western Blot 1:1000-10000, Immunocytochemistry 1:500, Immunoprecipitation 1:50 |
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| TMW: | 71 kDa |
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| Unit Size: | 0.1 ml |
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| Concentration: | Please see the vial label for concentration. |
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Packaging: | Storage: | Store at -20 °C. Avoid freeze-thaw cycles. |
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| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
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| Preservative: | 0.01% Sodium Azide |
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| Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. |
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Background: Lamins are nuclear membrane proteins that serve to maintain specific cellular functions, such as DNA replication and chromatin organization (1). Lamin B receptor (LBR) is an integral protein of the nuclear envelope inner membrane. It is phosphorylated by CDC2 protein kinase in mitosis when the inner nuclear membrane breaks down into vesicles that dissociate from the lamina and the chromatin. It is phosphorylated by different protein kinases in interphase when the membrane is associated with these structures (2). The cleavage of lamins results in nuclear disregulation and cell death (3,4).
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Images (2) Reviews (0) Related Products (10) Working with Lamin B Receptor
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Working with Lamin B Receptor
Lamin B Receptor Antibody (E398L) Images (2) Western Blot: Lamin B Receptor Antibody (E398L) [NB110-56894] - A. Western blot analysis on Jurkat cell lysate using anti-LBR (NB110-56894), dilution 1:500. |  Immunofluorescent: Lamin B Receptor Antibody (E398L) [NB110-56894] - B. Immunofluorescent staining of HeLa cells using anti-LBR. |
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Publications (1)Lamin B Receptor Antibody (E398L) Background References:- Gruenbaum, Y., et al. Review: nuclear lamins
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