Note: Not all species have been tested for usefulness with this product. Only those species listed have been tested. We cannot make any guarantees about additional reactivities which may or may not occur.
Synthetic peptide: C-DFSYNREDFAKA, corresponding to amino acids 318-329 of Human LXR alpha.
Species Reactivity:
Cross-reacts with Human.Not yet tested in other species.
Applications:
Uses:
By Western blot, this antibody detects an ~64 kDa protein representing recombinant human LXR alpha.
Dilutions:
Western Blot 1:300
Unit Size:
0.2 mg
Concentration:
1.0 mg/ml
Packaging:
Storage:
Store at -20 °C. Avoid freeze-thaw cycles.
Buffer:
PBS, 1 mg/ml BSA
Preservative:
0.05% Sodium Azide
Limitations:
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.
Liver X Receptors (LXRs) are oxysterol activated nuclear receptors which are involved in the regulation of cholesterol metabolism and bile acids. Two known isoforms, alpha and beta, are differentially expressed. The alpha isoform is predominantly expressed in liver, whereas the beta isoform expression has been shown to be ubiquitous.
DiBlasio-Smith EA, Arai M, Quinet EM, et al. Discovery and implementation of transcriptional biomarkers of synthetic LXR agonists in peripheral blood cells (BioMed Central). J Transl Med (2008).
Zhang, Chi., et al. Research Articles: NO-1886 upregulates ATP binding cassette transporter A1 inhibits diet-induced atherosclerosis in Chinese Bama minipigs. J. Lipid Res., 47: 2055-2063, 2006