LXR Antibody Summary:

Species:	Hu, Mu, Rt
Applications:	PEP-ELISA
Clonality:	Polyclonal

Gene:	NR1H3
Purity:	Immunogen affinity purified
Host:	Goat

Specificity:	This antibody is expected to recognise an epitope corresponding to aa 429-442 of human LXR alpha protein (NP_005684.2) and to aa 443-456 of human LXR beta protein (NP_009052.3).
Publications:	Antibody has at least 1 Background Reference.

Note: Not all species have been tested for usefulness with this product. Only those species listed have been tested. We cannot make any guarantees about additional reactivities which may or may not occur.

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Peptides and Proteins	Primary Antibodies

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LXR Antibody Details:

Isotype:	IgG
Immunogen:	Synthetic peptide CRLQDKKLPPLLSEI, representing the C-Terminus of the human protein according to NP_005684; NP_009052.

Species Reactivity:

Human, Mouse, Rat, Dog, Cow

Applications:

Uses:	This antibody is useful for Peptide ELISA and Western Blot. Approx 55kDa band observed in human spleen lysates (calculated MW of 50.5kDa according to NP_005684 and 50.1kDa according to NP_009052). Additional minor bands were also consistently observed at 38kDa and 75kDa. These bands were successfully blocked by incubation with the immunising peptide.
Dilutions:	Peptide ELISA 1:16000
Unit Size:	0.1 mg
Concentration:	0.5 mg/ml
Positive Controls:	1 Positive Controls

Packaging:

Storage:	Aliquot and store at -20 °C or -80 °C. Avoid freeze-thaw cycles.
Buffer:	Tris-saline (pH7.3) with 0.5% BSA
Preservative:	0.02% Sodium Azide
Limitations:	This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.

Gene Symbol: NR1H3

Entrez	10062 (Human)
Swiss Prot	NP_005684; NP_009052.

Background:

Liver X Receptors (LXRs) are oxysterol activated nuclear receptors which are involved in the regulation of cholesterol metabolism and bile acids. Two known isoforms, alpha and beta, are differentially expressed. The alpha isoform is predominantly expressed in liver, whereas the beta isoform expression has been shown to be ubiquitous.

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Working with LXR

LXR Antibody Images (1)

NB 100-1465 (1µg/ml) staining of Human Spleen lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

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Publications (1)

LXR Antibody Background References:

Tangirala RK et al. Identification of macrophage liver X receptors as inhibitors of atherosclerosis. Proc Natl Acad Sci U S A 99:11896-901 (2002).

Protocols

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Jump to: Positive Controls, Peptides and Proteins, Primary Antibodies, Secondary Antibodies

Related Products

Positive Controls

Name	Catalog#	Reactivity	Applications	Images	Publications	Reviews
LXR alpha Lysate	NBL1-13768		WB	(1)

Peptides and Proteins

Name	Catalog#	Reactivity	Applications	Images	Publications	Reviews
LXR Peptide	NB400-157PEP

Primary Antibodies (7)

Name	Catalog#	Reactivity	Applications	Images	Publications
LXR Antibody	NB400-157	Ch, Hu, Mk, Mu, Rt	WB	(2)	(4)
LXR Antibody [DyLight 550]	NB400-157R	Ch, Hu, Mk, Mu, Rt	WB
LXR Antibody [DyLight 488]	NB400-157G	Ch, Hu, Mk, Mu, Rt	WB
LXR Antibody [HRP]	NB400-157H	Ch, Hu, Mk, Mu, Rt	WB
LXR Antibody [DyLight 650]	NB400-157C	Ch, Hu, Mk, Mu, Rt	WB
... and 2 more. See All »

Secondary Antibodies

Name	Catalog#	Reactivity	Applications	Publications
Goat IgG Antibody [FITC]	NB710-F	Gt	ICC, IHC-P
Goat IgG Antibody [Biotin]	NB710-B	Gt	ELISA, ICC, IHC-P, WB
Goat IgG Antibody [Alkaline Phosphatase]	NB710-AP	Gt	ELISA, ICC, IHC-P, WB
Goat IgG Antibody [HRP]	NB710-H	Gt	ELISA, ICC, IHC-P, WB	(4)
Goat IgG Antibody [Cy3]	NB120-6949	Gt	ELISA, FACS, ICC, IF, IHC-Fr, IHC-P
See All »

Jump to: Novus Explorer, Research Areas

LXR in Context

Research Areas related to LXR (1):

Lipid and Metabolism

Novus Explorer for LXR gene

Try our bioinformatic tool that shows the relationships between NR1H3 and other genes, diseases, pathways and post-translational modifications.

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