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LOX propeptide Antibody (NBP1-30327)

LOX propeptide Antibody

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LOX propeptide Antibody Summary:
Species:Hu, Rt
Applications:FACS, ICC, IF, WB
Clonality:Polyclonal
Gene:LOX
Purity:Affinity purified
Host:Rabbit
Specificity:This antibody recognizes the glycosylated propeptide form (~35 kDa) and the proenzyme form (~50 kDa).
Publications:Antibody has been mentioned in at least 2 Publications.
Note: Not all species have been tested for usefulness with this product. Only those species listed have been tested. We cannot make any guarantees about additional reactivities which may or may not occur.
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LOX propeptide Antibody Details:
Immunogen:Synthetic peptide made to an internal portion of the human protein (within residues 118-168. [Swiss-Prot# P28300]
Species Reactivity:

Human and rat.

Applications:
Uses:This antibody is useful for Western Blot analysis where a band can be seen at ~35 kDa, the glycosylated propeptide form and ~50 kDa, the proenzyme form. This antibody is also useful for immunocytochemistry/immunofluorescence and Flow cytometry/analysis.
Dilutions:Flow Cytometry 1:200, Immunocytochemistry 1:200, Immunofluorescence 1:200, Western Blot 0.5 ug/ml
Unit Size: 0.1 ml (also available: 0.05 ml (sample size))
Concentration:1.0 mg/ml
Positive Controls:1 Positive Controls
Conjugated Antibodies:5 Conjugated Antibodies
Packaging:
Storage:Store at 4 °C short term. Aliquot and store at -20 °C long term. Avoid freeze-thaw cycles.
Buffer:PBS with 30% glycerol
Preservative:0.1% Sodium Azide
Limitations:This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.
Gene Symbol: LOX
Entrez4015 (Human)
Swiss ProtP28300 (Human)
 
Background:

Lysyl oxidase (LOX) is an extracellular enzyme that is critical for the normal biosynthesis of collagens and elastin. LOX is synthesized as a 50 kDa precursor, secreted into the extracellular matrix and subsequently proteolytically processed to a 30 kDa active enzyme and an 18 kDa propeptide. LOX also reverts ras-mediated transformation and its expression is down-regulated in human cancers. Most recently, the lysyl oxidase pro-peptide (LOPP) has been associated with tumor suppression, as it inhibits ras-dependent cellular transformation.
Images (3)
  • Immunoctyochemistry: LOX propeptide Antibody [NBP1-30327] – LOX propeptide staining in Hela cells detected with a Dylight 488 labeled secondary antibody (Green) with Hoechst 33258 nuclear counterstain (Blue).
  • Flow Cytometry: LOX propeptide Antibody [NB100-1833] - FACS staining of NTERA-2 cells using NP1-30327 at a 1:200 dilution detected using Dylight-488 conjugated goat anti-rabbit IgG secondary antibody.
  • Western Blot: LOX propeptide Antibody [NBP1-30327] - Western blot analysis of LOX propeptide on MDA-MB-231 using NBP1-30327.

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Secondary Antibodies

Exploring LOX propeptide

2 Related Research Areas

Working with LOX propeptide

2 Publications

1 Protocols and Procedures
Jump to: Publications, Images, Protocols/Procedures, Ask a Question

Working with LOX propeptide

LOX propeptide Antibody Images (3)
Immunoctyochemistry: LOX propeptide Antibody [NBP1-30327] – LOX propeptide staining in Hela cells detected with a Dylight 488 labeled secondary antibody (Green) with Hoechst 33258 nuclear counterstain (Blue). Flow Cytometry: LOX propeptide Antibody [NB100-1833] - FACS staining of NTERA-2 cells using NP1-30327 at a 1:200 dilution detected using Dylight-488 conjugated goat anti-rabbit IgG secondary antibody.
Western Blot: LOX propeptide Antibody [NBP1-30327] - Western blot analysis of LOX propeptide on MDA-MB-231 using NBP1-30327.
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Publications (2)

LOX propeptide Antibody Product Specific:

  1. Sato S, Trackman PC, Mäki JM, et al. The Ras Signaling Inhibitor LOX-PP Interacts with Hsp70 and c-Raf To Reduce Erk Activation and Transformed Phenotype of Breast Cancer Cells. Mol. Cell. Biol. 2011 July. [PMID 21536655]
  2. Sánchez-Morgan N, Kirsch KH, Trackman PC, Sonenshein GE. The Lysyl Oxidase Propeptide Interacts with the Receptor-Type Protein Tyrosine Phosphatase-Kappa (RPTP-{kappa}) and Inhibits {beta}-Catenin Transcriptional Activity in Lung Cancer Cells. Mol Cell Biol. 2011 Jun 20.[PMID: 21690299]
Protocols

Product Specific (1)


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Jump to: Conjugated Antibodies, Positive Controls, Peptides and Proteins, Primary Antibodies, Secondary Antibodies

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Conjugated Antibodies
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LOX propeptide Antibody [DyLight 650]NBP1-30327CHu, RtFACS, ICC, IF, WB

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LOX propeptide Antibody [DyLight 550]NBP1-30327RHu, RtFACS, ICC, IF, WB

LOX propeptide Antibody [Biotin]NBP1-30327BHu, RtFACS, ICC, WB

LOX propeptide Antibody [HRP]NBP1-30327HHu, RtFACS, ICC, WB

Positive Controls
NameCatalog#ReactivityApplicationsImagesPublicationsReviews
Jurkat Whole Cell LysateNB800-PC2(2)

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LOX propeptide AntibodyNB110-41568Hu, Mk, Mu, Po, RtICC, IF, IHC, IHC-P, WB(3)(1)

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LOX propeptide Antibody [DyLight 488]NB110-41568GHu, Mk, Mu, Po, RtIHC, IHC-P, WB

LOX propeptide Antibody [DyLight 650]NB110-41568CHu, Mk, Mu, Po, RtIHC, IHC-P, WB

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Secondary Antibodies
NameCatalog#ReactivityApplicationsImagesPublicationsReviews
Rabbit IgG Antibody [HRP]NB730-HRbELISA, ICC, IHC-P, WB(5)

Rabbit IgG Antibody [FITC]NB730-FRbICC, IHC-P(1)

Rabbit IgG Antibody [Biotin]NB730-BRbELISA, ICC, IHC-P, WB

Rabbit IgG, H/L Chains Antibody [DyLight 488]NBP1-72944RbFLISA, IF, WB(3)

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LOX propeptide in Context

Research Areas related to LOX propeptide (2):
Novus Explorer for LOX propeptide gene
Try our bioinformatic tool that shows the relationships between LOX and other genes, diseases, pathways and post-translational modifications.