LDLR (AAH14514, 1 a.a. - 861 a.a.) recombinant protein with a ~26kD N-terminal GST tag.
Note: Not all species have been tested for usefulness with this product. Only those species listed have been tested. We cannot make any guarantees about additional reactivities which may or may not occur.
This protein is not active and should not be used for experiments requiring activity.
Species Reactivity:
Human
Applications:
Uses:
Useful in Western Blot and ELISA. This protein has not been tested for any functionality. This product may contain endotoxins and is not suitable for use with live cells.
This product is produced by and distributed for Abnova, a company based in Taiwan.
Packaging:
Storage:
Store at -80 °C. Avoid freeze-thaw cycles.
Buffer:
Tris-HCI + Glutathione, pH=8.0
Limitations:
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia.
LDLR( AAH14514, 1 a.a. - 861 a.a.) recombinant protein with GST.