LDL Receptor Peptide (NBP1-06709PEP)

LDL Receptor Peptide

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LDL Receptor Peptide Summary:
Protein Type:Peptide
Applications:WB
Gene:LDLR
Purity:Peptide affinity purified
 
Publications:Antibody has at least 3 Background References.
Note: Not all species have been tested for usefulness with this product. Only those species listed have been tested. We cannot make any guarantees about additional reactivities which may or may not occur.
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LDL Receptor Peptide Details:
Immunogen:Synthetic peptide made to an internal portion of the human protein (within residues 500-550). [Swiss-Prot# P01130]
Localization:Membrane; Single-pass type I membrane protein. Membrane ? clathrin-coated pit; Single-pass type I membrane protein.
Applications:
Uses:This peptide is useful as a negative control for Western blot.
Dilutions:Western Blot 0.5 ug/ml
Unit Size:0.1 ml
Concentration:Please see the vial label for concentration.
Positive Controls:1 Positive Controls
Packaging:
Storage:Store at -80 °C. Avoid freeze-thaw cycles.
Buffer:PBS, 30% glycerol
Preservative:0.1% Sodium Azide
Limitations:This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.
Gene Symbol: LDLR
Entrez3949 (Human)
16835 (Mouse)
Swiss ProtP01130 (Human)
 
Background:

The low density lipoprotein (LDL) receptor system coordinates the metabolism of cholesterol, an essential component of the plasma membrane of all mammalian cells. Study of this system has led to an enhanced understanding of the cellular basis of cholesterol homeostasis. It has also brought into focus an important mechanism of metabolic regulation--the process of receptor-mediated endocytosis (1). Data suggest that the juxtamembranous region of the cytoplasmic domain participates in protein:protein interactions that allow the low density lipoprotein receptor to cluster in coated pits (2). It has been shown that the family of LDL receptors may serve as viral receptors. Endocytosis of the Flaviviridae viruses, hepatitis C virus, GB virus C/hepatitis G virus, and bovine viral diarrheal virus (BVDV) was shown to be mediated by LDL receptors on cultured cells (3).

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Publications (3)

LDL Receptor Peptide Background References:

  1. Agnello V, et al. Proc Natl Acad Sci 96(22):12766-71, 1999
  2. Davis CG, et al. J Biol Chem 262(9):4075-82, 1987.

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Jump to: Positive Controls, Lysates, Peptides and Proteins, Primary Antibodies, RNAi

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Positive Controls
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Lysates (2)
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LDL Receptor LysateH00003949-T01HuWB(2)

LDL Receptor LysateNBL1-12475WB(1)

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LDL Receptor Recombinant ProteinH00003949-P01HuELISA, WB(1)

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LDL Receptor Antibody (C7)NBP1-78159Bv, HuICC, IF, IHC-P, IP, WB(2)(6)

LDL Receptor AntibodyNBP1-06709Hu, Mk, MuWB(1)(3)

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RNAi (1)
NameCatalog#ReactivityApplicationsImagesPublicationsReviews
LDL Receptor RNAiH00003949-R01Hu(1)(4)


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