LDL Receptor Antibody (EP1553Y) (NB110-57162)

LDL Receptor Antibody (EP1553Y) (NB110-57162) (0.1 ml)

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	Catalog Number	NB110-57162
	Size(s)	0.1 ml	Price:
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anti-FHC antibody, anti-low-density lipoprotein receptor class A domain-containing protein 3 antibody, anti-FH antibody, anti-low-density lipoprotein receptor antibody, anti-LDL receptor antibody, anti-LDLCQ2 antibody, anti-low density lipoprotein receptor antibody

LDL Receptor Antibody (EP1553Y) Summary:

Species:	Hu, Mu, Rt	Gene:	LDLR
Applications:	WB, FACS, ICC, IHC-P, IP	Purity:	Whole antisera
Clonality:	Monoclonal	Host:	Rabbit
Specificity:	This antibody detects both isoforms of LDL receptor.
Publications:	NB110-57162 has been mentioned in at least 3 Publications

View Additional LDL Receptor Products

Lysates	Peptides and Proteins
Primary Antibodies	RNAi
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LDL Receptor Antibody (EP1553Y) Details:

Clone:	EP1553Y
Isotype:	IgG
Immunogen:	A synthetic peptide corresponding to residues on the C-terminus of human LDL receptor was used as an immunogen.

Species Reactivity:

Reacts in Human, Mouse, Rat. Rat cross reactivity tested by western blot only

Applications:

Uses:	This product is useful for: Western Blot, Immunohistochemistry-Paraffin, Immunocytochemistry, Immunoprecipitation, Flow Cytometry. In Western blot this antibody detects a band at approximately 140/160, two isoforms.
Dilutions:	Western Blot 1:1000-10000, Immunohistochemistry-Paraffin 1:100-250, Immunocytochemistry 1:100-250, Immunoprecipitation 1:50, Flow Cytometry 1:70
Unit Size:	0.1 ml
Concentration:	This product is unpurified. Concentration is not relevant.
Positive Controls:	1 Positive Controls

Packaging:

Storage:	Store at -20°C. Avoid freeze-thaw cycles.
Buffer:	50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA.
Preservative:	0.01% Sodium Azide
Limitations:	This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.

Gene Symbol: LDLR

Entrez:	3949 (Human)
	16835 (Mouse)
	300438 (Rat)
Uniprot:	P01130 (Human)

Related Genes:

Background:

The low density lipoprotein (LDL) receptor system coordinates the metabolism of cholesterol, an essential component of the plasma membrane of all mammalian cells. Study of this system has led to an enhanced understanding of the cellular basis of cholesterol homeostasis. It has also brought into focus an important mechanism of metabolic regulation--the process of receptor-mediated endocytosis (1). Data suggest that the juxtamembranous region of the cytoplasmic domain participates in protein:protein interactions that allow the low density lipoprotein receptor to cluster in coated pits (2). It has been shown that the family of LDL receptors may serve as viral receptors. Endocytosis of the Flaviviridae viruses, hepatitis C virus, GB virus C/hepatitis G virus, and bovine viral diarrheal virus (BVDV) was shown to be mediated by LDL receptors on cultured cells (3).

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Reviews (1)

Anonymous on 7/30/2009

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LDL Receptor Antibody (EP1553Y) Images (3)

	Western Blot: LDL Receptor Antibody (EP1553Y) [NB110-57162] - Western blot analysis on HepG2 cell lysate using anti-LDL receptor, dilution 1:5000.

	Immunofluorescent: LDL Receptor Antibody (EP1553Y) [NB110-57162] - Immunofluorescent staining of HEPG2 cells.

	Immunohistochemistry: LDL Receptor Antibody (EP1553Y) [NB110-57162] - Immunohistochemical staining of paraffin-embedded human liver.

Reviews (1) Have you used this product? Review this product to earn Novus Rewards.

Reviewed by:
Anonymous 7/30/2009

Application:	Western Blot
Sample Tested:	cell lines (Hep2 HepG2)
Sample Loaded:	50ug
Lot:	YD112703
Results:	"So far the best antibody for LDLr receptor. I did try a bunch of them (from Abcam for example without success). Wish you have one good antibody for the LRP receptor"