LDL Receptor Antibody (H00003949-M02)

LDL Receptor Antibody (5E6)

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LDL Receptor Antibody (5E6) Summary:
Species:Hu
Applications:ELISA, WB
Clonality:Monoclonal
Gene:LDLR
Purity:IgG purified
Host:Mouse
Specificity:LDLR - low density lipoprotein receptor (familial hypercholesterolemia) (5E6)
 
Note: Not all species have been tested for usefulness with this product. Only those species listed have been tested. We cannot make any guarantees about additional reactivities which may or may not occur.
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LDL Receptor Antibody (5E6) Details:
Clone:5E6
Isotype:IgG2a Kappa
Immunogen:LDLR (NP_000518, 105 a.a. ~ 206 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Epitope:PPKTCSQDEFRCHDGKCISRQFVCDSDRDC LDGSDEASCPVLTCGPASFQCNSSTCIPQL WACDNDPDCEDGSDEWPQRCRGLYVFQGDS SPCSAFEFHCL*
Species Reactivity:

Human.

Applications:
Uses:Antibody Reactive Against Recombinant Protein with GST tag on ELISA and Western Blot. GST tag alone is used as a negative control.
Dilutions:Western Blot 1:500, ELISA
Unit Size:0.05 mg
Concentration:Please see the vial label for concentration.
Notes:
This product is produced by and distributed for Abnova, a company based in Taiwan.
Packaging:
Storage:Aliquot and store at -20 °C or -80 °C. Avoid freeze-thaw cycles.
Buffer:In 1x PBS, pH 7.2
Preservative:No Preservative
Limitations:This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.
Gene Symbol: LDLR
Entrez3949 (Human)
Swiss ProtNP_000518 (Human)
 
Background:

The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. [provided by RefSeq]

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Working with LDL Receptor

LDL Receptor Antibody (5E6) Images (1)
Detection limit for recombinant GST tagged LDLR is approximately 0.03ng/ml as a capture antibody.
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Jump to: Lysates, Peptides and Proteins, Primary Antibodies, RNAi, Secondary Antibodies

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