LC3C Antibody (R-140-100)
LC3C Antibody
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anti-Microtubule-associated proteins 1A/1B light chain 3C antibody, biosensis. GENE NAME: MAP1LC3C antibody, anti-Microtubule-associated protein 1 light chain 3 gamma antibody, anti-MAP1A/MAP1B LC3 C antibody, anti-MAP1A/1B light chain 3 C antibody, anti-MAP1 light chain 3-like protein 3 antibody, anti-Autophagy-related ubiquitin-like modifier LC3 C antibody, anti-Autophagy-related protein LC3 C antibody, anti-APG8c, |
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LC3C Antibody Summary: | | Gene: | MAP1LC3C |
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| Purity: | Whole antisera |
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| Host: | Rabbit |
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| | Specificity: | IHC and WB confirmed the specificity for MAP1LC3 C (MAP1LC3C, APG8c). This should recognise MAP1LC3 C only and not the other forms MAP1LC3A and MAP1LC3B. |
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| Publications: | Antibody has been mentioned in at least 1 Publication. |
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| | Note: Not all species have been tested for usefulness with this product. Only those species listed have been tested. We cannot make any guarantees about additional reactivities which may or may not occur. |
View Additional LC3C Products LC3C Antibody Details: | Immunogen: | A synthetic peptide (CQEEVAGIRAKF) corresponding to the N-terminal of human MAP1LC3 C (MAP1LC3C, APG8c) conjugated to Blue Carrier Protein has been used as the immunogen. The peptide is homologous with the corresponding sequence deriven from MAP1LC3 C (MAP1LC3C, APG8c) protein in Macaca mulatta (monkey) and Canis familiaris (dog). |
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| Localization: | Accession Number: MLP3C_HUMAN |
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Human, other species have not yet been tested. |
| Uses: | IHC-P, immunofluorescence, WB. A dilution of 1:100 to 1:1000 dilution is recommended for these applications. The optimal working dilution should be determined by the end user. |
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| Dilutions: | Immunofluorescence, Immunohistochemistry-Paraffin, Western Blot |
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| Unit Size: | 0.1 ml |
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| Concentration: | lyoph |
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Packaging: | Storage: | Store at 4 °C short term. Aliquot and store at -20 °C long term. Avoid freeze-thaw cycles. |
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| Buffer: | Lyophilized. Add diH20 to desired concentration. |
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| Preservative: | No Preservative |
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| Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. |
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Background: FUNCTION: Probably involved in formation of autophagosomal vacuoles (autophagosomes). SUBUNIT: 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins. SUBCELLULAR LOCATION: LC3-I: Cytoplasm. LC3-II: Intracytoplasmic membrane; lipid-anchor. LC3-II binds to the autophagic membranes. TISSUE SPECIFICITY: Most abundant in placenta, lung and ovary. PTM: The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II. SIMILARITY: Belongs to the MAP1 LC3 family.
This product is distributed on behalf of Biosensis Pty. Ltd. of Australia.
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Images (5) Reviews (0) Related Products (7) Exploring LC3C Working with LC3C
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Jump to: Publications, Images, Ask a Question
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Working with LC3C
LC3C Antibody Images (5) Immunofluorescence: MAP1LC3 C Antibody [R-140-100] - Confocal microscopy on immunofluorescently detected MAP1LC3 C (MAP1LC3C, APG8c) in cytospin-isolated human white blood cells using Rabbit antibody to MAP1LC3 C (MAP1LC3C, APG8c): whole serum (R-140-100) at a dilution of 1: 200, incubated for 1 h at room temperature. The detected MAP1LC3 C (MAP1LC3C, APG8c) appears red. The cells were also stained for Myeloperoxidase (MPO) appearing in green. The cells were counter stained with Hoechst Dye (blue colour). Here, the merged picture is presented. |  Immunofluorescence: MAP1LC3 C Antibody [R-140-100] - Confocal microscopy on immunofluorescently detected MAP1LC3 C (MAP1LC3C, APG8c) in cytospin-isolated human white blood cells using Rabbit antibody to MAP1LC3 C (MAP1LC3C, APG8c): whole serum (R-140-100) at a dilution of 1: 200, incubated for 1 h at room temperature. The detected MAP1LC3 C (MAP1LC3C, APG8c) appears red. The cells were also stained for Myeloperoxidase (MPO) appearing in green. The cells were counter stained with Hoechst Dye (blue colour). Here, the merged picture is presented. |  Immunofluorescence: MAP1LC3 C Antibody [R-140-100] - Confocal microscopy on immunofluorescently detected MAP1LC3 C (MAP1LC3C, APG8c) in cytospin-isolated human white blood cells using Rabbit antibody to MAP1LC3 C (MAP1LC3C, APG8c): whole serum (R-140-100) at a dilution of 1: 200, incubated for 1 h at room temperature. The detected MAP1LC3 C (MAP1LC3C, APG8c) appears red. The cells were also stained for Myeloperoxidase (MPO) appearing in green. The cells were counter stained with Hoechst Dye (blue colour). Here, the merged picture is presented. |  Immunofluorescence: MAP1LC3 C Antibody [R-140-100] - Confocal microscopy on immunofluorescently detected MAP1LC3 C (MAP1LC3C, APG8c) in cytospin-isolated human white blood cells using Rabbit antibody to MAP1LC3 C (MAP1LC3C, APG8c): whole serum (R-140-100) at a dilution of 1: 200, incubated for 1 h at room temperature. The detected MAP1LC3 C appears red. The cells were also stained for Myeloperoxidase (MPO) appearing in green. The cells were counter stained with Hoechst Dye (blue colour). Here, the merged picture is presented. |  Western Blot: MAP1LC3 C Antibody [R-140-100] - Western blot under reduceding condition on 293 cell lysate using Rabbit antibody to MAP1LC3 C (MAP1LC3C, APG8c): whole serum (R-140-100) at a dilution of 1:100. |
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Publications (1)LC3C Antibody Product Specific:- Greenberg JT. Dev Cell. 8(6):799-801. (2005) ;
2. Baehrecke EH. Nat Rev Mol Cell Biol. 6(6):505-10. (2005) ;
3. Levine B. Cell. 120(2):159-62. (2005) ;
4. Tanida I., et al. J. Biol. Chem. 279:36268-36276(2004) ;
5. Lum JJ, et al. Nat Rev Mol Cell Biol. 6(6):439-48. (2005) ;
6. Tanida I., et al. Int. J. Biochem. Cell Biol. 36:2503-2518(2004)
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