Integrin alpha 6/CD49f Antibody (NKI-GoH3) [Biotin] 0.1 mg

Click image to view larger
Flow Cytometry: Integrin alpha 6 Antibody (NKI-GoH3) [Biotin] [NB100-63904] Staining of human peripheral blood platelets with Rat anti Human CD49f:Biotin
Flow Cytometry: Integrin alpha 6 Antibody (NKI-GoH3) [Biotin] [NB100-63904] - Staining of human peripheral blood lymphocytes.
Download Datasheet
See All Related

Ordering Information: NB100-63904

  • Catalog Number
    NB100-63904
  • Displayed Format
    Biotin
  • Other Formats
  • Size(s)
    0.1 mg
  • Availability
  • Price
    Shipping
  

Integrin alpha 6/CD49f Antibody (NKI-GoH3) [Biotin] Summary

Species Human, Mouse, Canine, Primate
Tested Applications FLOW
Clonality
Monoclonal
Host
Rat
Gene
ITGA6
Purity
Protein G purified
Specificity
NB100-63904 recognizes CD49F (VLA-6 alpha chain), a 120kD cell surface glycoprotein that can form distinct complexes with CD29 (VLA beta-chain), resulting in the VLA-6 (alpha-6 beta-1) complex, which is expressed on human platelets, or with the beta-4 integrin resulting in the alpha-6 beta-4 complex which is expressed on various human epithelial cells. Clone NKI-GoH3 reacts with platelets, megakaryocytes, T lymphocytes and common Acute Lymphoblastic Leukaemia cells (alpha-6 beta-1). In immunohistology the monoclonal antibody reacts with epithelial cells of a variety of tissues, peripheral nerves, microvascular endothelial cells, placenta cyto- and syncytotrophoblasts.VLA-6 is an important mediator of cell binding to laminin. Studies suggest that clone GoH3 specifically blocks the binding of cells to the E8 fragment of laminin (7).
Guarantee Plus
All of our products are backed by our 100% guarantee to work for stated and predicted species and applications.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Integrin alpha 6/CD49f Antibody (NKI-GoH3) [Biotin] Details

Format
Biotin
Clone
NKI-GoH3
Isotype
IgG2a
Immunogen
BALB/c mouse mammary tumour cells

Species Reactivity

Cross reacts with Cynomolgus monkey, Monkey, Dog, Human and Mouse.

Applications/Dilutions

Dilutions
  • Flow Cytometry 1:10-1:1000
Positive Controls
Other Available
Formats
FITC Labeled NB100-63905
PE Labeled NB100-63906
Readout System

Contact Information

Product PDFs

Frequently Purchased Together

Reviews

Earn rewards points by submitting your review for Integrin alpha 6/CD49f Antibody (NB100-63904). Be the first to review this product and earn double rewards points!

Publications

Earn rewards if you have published using Integrin alpha 6/CD49f Antibody (NB100-63904).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
Phosphate buffered saline pH7.4
Unit Size
0.1 mg
Concentration
0.1 mg/ml
Preservative
0.09% Sodium Azide
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

Gene Symbol ITGA6
Entrez
Uniprot

Alternate Names for Integrin alpha 6/CD49f Antibody (NKI-GoH3) [Biotin]

  • CD49 antigen-like family member F
  • CD49f
  • CD49f antigen
  • DKFZp686J01244
  • FLJ18737
  • integrin alpha-6
  • integrin alpha6B
  • integrin, alpha 6
  • ITGA6B
  • VLA-6
Show More

Related Products by Gene

Background

Integrins are important extracellular matrix (ECM) receptor proteins located on cell surfaces. They are hetrodimers composed of an alpha and a beta transmembrane glycoprotein subunit. Around twenty two different integrins (different alpha/ beta subunit combinations) are found in nature. Integrins are generally present in high concentrations at the cell surface, but, unlike most other cell surface receptors, they bind ligands with very low affinity. Due to their weak individual binding, integrins need to cluster and bind in groups in order to effectively bind the ECM. Integrins bind many different ligands including laminin. Each integrin is made up of a large N terminal extracellular domain that binds the ECM ligand and a small C terminal cytoplasmic domain that mediates interaction with the actin cytoskeleton and signaling function. Integrin alpha 6 complexes are receptors for laminins, which are components of basement membranes. Integrin alpha 6 complexes may play an important role in embryogenesis.

Reviews for Integrin alpha 6/CD49f Antibody (NB100-63904) (0)

There are no reviews for Integrin alpha 6/CD49f Antibody (NB100-63904).
By submitting a review earn points towards our Rewards Program.
  • 250 points for product review
  • 500 additional points for an image with your product review
  • Double points (500) if you are the first to review this product
  • Double points (1000) if you are the first to review this product with an image
Have you used Integrin alpha 6/CD49f Antibody (NB100-63904)? Submit your review and earn rewards points which can be used for merchandise & discounts.
Points can be redeemed for discounts and gift cards:
$50/€35/£30/$50CAN Amazon Gift Card1000 Points
Items ships for Free, please disregard any shipping charges.
$50/€35/£30/$50CAN Off Purchase (credited after checkout)1000 Points
Discount is removed from total when the order is processed. The discount will not appear in your shopping cart on check out.

Publications for Integrin alpha 6/CD49f Antibody (NB100-63904) (0)

There are no publications for Integrin alpha 6/CD49f Antibody (NB100-63904).
By submitting a publication earn 200 points for your submission points towards our Rewards Program.
Have you published using Integrin alpha 6/CD49f Antibody (NB100-63904)? Earn rewards points which can be used for merchandise & discounts.
Points can be redeemed for discounts and gift cards:
$50/€35/£30/$50CAN Amazon Gift Card1000 Points
Items ships for Free, please disregard any shipping charges.
$50/€35/£30/$50CAN Off Purchase (credited after checkout)1000 Points
Discount is removed from total when the order is processed. The discount will not appear in your shopping cart on check out.

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Ask a Scientist

Submit your question on below.
During business hours, we will respond to your email within 24 hours. For any questions submitted on the weekend, a response will be received on Monday.
For immediate assistance during business hours M- F (excluding major holidays), please contact us.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

FAQs for Integrin alpha 6/CD49f (2)

  1. In the immunohistochemistry paraffin section protocol....the PBS buffer....should it be at certain pH?
    • For IHC application, different labs cites the pH of PBS buffer in the range of 7.1 - 7.6 but most commonly used pH is pH 7.4 (this is what we use in our lab). You may use this PBS (pH 7.4) for making permeablization buffer, antibody diluent buffers and for making wash buffer. For more on the protocol that we use in our lab and for IHC-P troubleshooting suggestions, you may visit: IHC-P Protocol and IHC-P Troubleshooting.
  2. I was wondering what does Format 7C mean as far as anitbodies go?
    • 7C is a fluorophore - it is useful for FLOW. The details of the fluor are (A=425, E=500)

Bioinformatics Tool for Integrin alpha 6/CD49f

Discover related pathways, diseases and genes to Integrin alpha 6/CD49f. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Bioinformatics Tool

Research Areas for Integrin alpha 6/CD49f

Find related products by research area.

PTMs for Integrin alpha 6/CD49f

Learn more about PTMs related to Integrin alpha 6/CD49f.

Blogs on Integrin alpha 6/CD49f

There are no specific blogs for Integrin alpha 6/CD49f, but you can read our latest blog posts.