Integrin alpha 6 Antibody (NKI-GoH3) [Biotin] 0.1 mg

Integrin alpha 6 NB100-63904

Contact Information

Choose a country to view pricing and purchasing information.

More on NB100-63904

  • All Integrin alpha 6 Products
  • Alternate Names
     
  • Submit a Review

Ordering Information: NB100-63904

Catalog NumberNB100-63904
  • FormBiotin
  • Formats
  • Size(s)0.1 mg
  • Price, Shipping
    & Availability
     

     
  •  

Integrin alpha 6 Antibody (NKI-GoH3) [Biotin] Summary

 
Species Human, Mouse, Canine, Primate
Tested Applications FLOW
Clonality Monoclonal
Host Rat
Gene ITGA6
Purity Protein G purified
Specificity NB100-63904 recognizes CD49F (VLA-6 alpha chain), a 120kD cell surface glycoprotein that can form distinct complexes with CD29 (VLA beta-chain), resulting in the VLA-6 (alpha-6 beta-1) complex, which is expressed on human platelets, or with the beta-4 integrin resulting in the alpha-6 beta-4 complex which is expressed on various human epithelial cells. Clone NKI-GoH3 reacts with platelets, megakaryocytes, T lymphocytes and common Acute Lymphoblastic Leukaemia cells (alpha-6 beta-1). In immunohistology the monoclonal antibody reacts with epithelial cells of a variety of tissues, peripheral nerves, microvascular endothelial cells, placenta cyto- and syncytotrophoblasts.VLA-6 is an important mediator of cell binding to laminin. Studies suggest that clone GoH3 specifically blocks the binding of cells to the E8 fragment of laminin (7).
Guarantee Plus All of our products are backed by our 100% guarantee to work for stated and predicted species and applications.
Innovator's Reward Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Integrin alpha 6 Antibody (NKI-GoH3) [Biotin] Details

 
Format Biotin
Clone NKI-GoH3
Isotype IgG2a
Immunogen BALB/c mouse mammary tumour cells

Species Reactivity

 
Cross reacts with Cynomolgus monkey, Monkey, Dog, Human and Mouse.

Applications/Dilutions

 
Dilutions
  • Flow Cytometry 1:10-1:1000
Positive Controls

1 Positive Control

Other Available
Formats
FITC Labeled NB100-63905
PE Labeled NB100-63906
Learn about Custom Antibody Labeling
Readout System

Product PDFs

Reviews

Earn rewards points by submitting your review for Integrin alpha 6 Antibody (NB100-63904).
Submit a Review

Publications

Earn rewards if you have published using Integrin alpha 6 Antibody (NB100-63904).
Submit a Publication

Protocols and FAQs

Controls & Support Products

Research Tools

View all Integrin alpha 6 Research Tools.

Packaging, Storage & Formulations

 
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer Phosphate buffered saline pH7.4
Unit Size 0.1 mg
Concentration 0.1 mg/ml
Preservative 0.09% Sodium Azide
Limitations This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

 
Gene Symbol ITGA6
Entrez
Uniprot

Alternate Names for Integrin alpha 6

 
  • CD49f antigen
  • ITGA6B
  • integrin alpha6B
  • FLJ18737
  • integrin alpha-6
  • DKFZp686J01244
  • CD49 antigen-like family member F
  • VLA-6
  • CD49f
  • integrin, alpha 6

Related Products by Gene

Background

 
Integrins are important extracellular matrix (ECM) receptor proteins located on cell surfaces. They are hetrodimers composed of an alpha and a beta transmembrane glycoprotein subunit. Around twenty two different integrins (different alpha/ beta subunit combinations) are found in nature. Integrins are generally present in high concentrations at the cell surface, but, unlike most other cell surface receptors, they bind ligands with very low affinity. Due to their weak individual binding, integrins need to cluster and bind in groups in order to effectively bind the ECM. Integrins bind many different ligands including laminin. Each integrin is made up of a large N terminal extracellular domain that binds the ECM ligand and a small C terminal cytoplasmic domain that mediates interaction with the actin cytoskeleton and signaling function. Integrin alpha 6 complexes are receptors for laminins, which are components of basement membranes. Integrin alpha 6 complexes may play an important role in embryogenesis.