Integrin alpha 6 Antibody (NKI-GoH3) [Biotin] 0.1 mg

Integrin alpha 6 NB100-63904

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Ordering Information: NB100-63904

Catalog NumberNB100-63904
  • FormBiotin
  • Formats
  • Size(s)0.1 mg
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Integrin alpha 6 Antibody (NKI-GoH3) [Biotin] Summary

Species Human, Mouse, Canine, Primate
Tested Applications FLOW
Clonality Monoclonal
Host Rat
Gene ITGA6
Purity Protein G purified
Specificity NB100-63904 recognizes CD49F (VLA-6 alpha chain), a 120kD cell surface glycoprotein that can form distinct complexes with CD29 (VLA beta-chain), resulting in the VLA-6 (alpha-6 beta-1) complex, which is expressed on human platelets, or with the beta-4 integrin resulting in the alpha-6 beta-4 complex which is expressed on various human epithelial cells. Clone NKI-GoH3 reacts with platelets, megakaryocytes, T lymphocytes and common Acute Lymphoblastic Leukaemia cells (alpha-6 beta-1). In immunohistology the monoclonal antibody reacts with epithelial cells of a variety of tissues, peripheral nerves, microvascular endothelial cells, placenta cyto- and syncytotrophoblasts.VLA-6 is an important mediator of cell binding to laminin. Studies suggest that clone GoH3 specifically blocks the binding of cells to the E8 fragment of laminin (7).
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Integrin alpha 6 Antibody (NKI-GoH3) [Biotin] Details

Format Biotin
Clone NKI-GoH3
Isotype IgG2a
Immunogen BALB/c mouse mammary tumour cells

Species Reactivity

Cross reacts with Cynomolgus monkey, Monkey, Dog, Human and Mouse.


  • Flow Cytometry 1:10-1:1000
Positive Controls

1 Positive Control

Other Available
FITC Labeled NB100-63905
PE Labeled NB100-63906
Learn about Custom Antibody Labeling
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Packaging, Storage & Formulations

Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer Phosphate buffered saline pH7.4
Unit Size 0.1 mg
Concentration 0.1 mg/ml
Preservative 0.09% Sodium Azide
Limitations This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.


Gene Symbol ITGA6

Alternate Names for Integrin alpha 6

  • CD49f antigen
  • ITGA6B
  • integrin alpha6B
  • FLJ18737
  • integrin alpha-6
  • DKFZp686J01244
  • CD49 antigen-like family member F
  • VLA-6
  • CD49f
  • integrin, alpha 6

Related Products by Gene


Integrins are important extracellular matrix (ECM) receptor proteins located on cell surfaces. They are hetrodimers composed of an alpha and a beta transmembrane glycoprotein subunit. Around twenty two different integrins (different alpha/ beta subunit combinations) are found in nature. Integrins are generally present in high concentrations at the cell surface, but, unlike most other cell surface receptors, they bind ligands with very low affinity. Due to their weak individual binding, integrins need to cluster and bind in groups in order to effectively bind the ECM. Integrins bind many different ligands including laminin. Each integrin is made up of a large N terminal extracellular domain that binds the ECM ligand and a small C terminal cytoplasmic domain that mediates interaction with the actin cytoskeleton and signaling function. Integrin alpha 6 complexes are receptors for laminins, which are components of basement membranes. Integrin alpha 6 complexes may play an important role in embryogenesis.