IRS2 Antibody (NB100-68242)
IRS2 Antibody
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Distributor Data...
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anti-IRS2 antibody, anti-IRS-2 antibody, anti-insulin receptor substrate 2 antibody, |
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IRS2 Antibody Summary: | | Gene: | IRS2 |
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| Purity: | Immunogen affinity purified |
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| Host: | Rabbit |
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| | | Note: Not all species have been tested for usefulness with this product. Only those species listed have been tested. We cannot make any guarantees about additional reactivities which may or may not occur. |
View Additional IRS2 Products IRS2 Antibody Details: | Isotype: | IgG |
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| Immunogen: | The epitope recognized by this antibody maps to a region between residue 600 and 650 of human insulin receptor substrate 2 using the numbering given in entry NP_003740.2 (GeneID 8660). |
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| Uses: | Western Blot and Immunoprecipitation |
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| Dilutions: | Western Blot 1:2000-1:10000
immunoprecipitation 2-5 ug/mg lysate |
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| Unit Size: | 0.01 ml |
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| Concentration: | 0.2 mg/ml |
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Packaging: | Storage: | Store at 4 °C. Do not freeze. |
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| Buffer: | Tris-buffered Saline containing 0.1% BSA |
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| Preservative: | 0.09% Sodium Azide |
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| Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. |
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Background: IRS2 is a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1 (IGF1), and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. IRS2 is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment.
IRS2-deficient mice display all the characteristics of type 2 diabetes, suggesting that dysfunction of the IRS2 gene may contribute to the pathogenesis of human type 2 diabetes. Recent work has demonstrated a critical role for IRS2 in the maintenance of peripheral insulin sensitivity, central leptin sensitivity, proper beta cell development in the islets of Langerhans and expansion of functional beta-cell mass in vivo.
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Images (1) Reviews (0) Related Products (14) Exploring IRS2
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Working with IRS2
IRS2 Antibody Images (1) Western Blot and Immunoprecipitation: IRS2 Antibody [NB100-68242] - Detection of Human IRS2 NB100-68242. IRS2 was also immunoprecipitated by rabbit anti-IRS2 antibodies NB100-68243 and NB100-68244. |
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Jump to: Peptides and Proteins, Primary Antibodies, Secondary Antibodies
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Related ProductsPeptides and ProteinsPrimary Antibodies (13)| Name | Catalog# | Reactivity | Applications | Images | Publications | Reviews | |
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| IRS2 [p Ser731] Antibody | NBP1-72215 | Hu, Mu, Rt | ELISA, IHC-P, IP, WB | (2) | (1) | | | | IRS2 Antibody | NBP1-96563 | Hu, Mu | FACS, IHC-P, WB | (3) | | | | | IRS2 Antibody (EP903Y) | NB110-57138 | Hu, Mu(-), Rt(-) | ICC, IP, WB | (2) | (1) | | | | IRS2 Antibody | NBP1-74482 | Hu, Mu, Rt | ELISA, IHC-P, IP, WB | (2) | (1) | | | | IRS2 Antibody | NB100-68243 | Hu | IP, WB | (1) | | | | | ... and 8 more. See All » |
Secondary Antibodies| Name | Catalog# | Reactivity | Applications | Images | Publications | Reviews | |
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| Rabbit IgG Antibody [HRP] | NB730-H | Rb | ELISA, ICC, IHC-P, WB | | (5) | | | | Rabbit IgG Antibody [FITC] | NB730-F | Rb | ICC, IHC-P | | (1) | | | | Rabbit IgG Antibody [Biotin] | NB730-B | Rb | ELISA, ICC, IHC-P, WB | | | | | | Rabbit IgG, H/L Chains Antibody [DyLight 488] | NBP1-72944 | Rb | FLISA, IF, WB | (3) | | | | | Rabbit IgG Antibody [Alkaline Phosphatase] | NB730-AP | Rb | ELISA, ICC, IHC-P, WB | | (1) | | | | See All » |
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