IRE1 alpha [p Ser724] Antibody (NB100-2323)

IRE1 alpha [p Ser724] Antibody (NB100-2323) (0.1 ml)

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	Catalog Number	NB100-2323 (Sample Size Available)
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anti-FLJ30999 antibody, anti-EC 2.7.11 antibody, anti-hIRE1p antibody, anti-Ire1-alpha antibody, anti-IRE1a antibody, anti-serine/threonine-protein kinase/endoribonuclease IRE1 antibody, anti-Inositol-requiring protein 1 antibody, anti-protein kinase/endoribonuclease antibody, anti-Endoplasmic reticulum-to-nucleus signaling 1 antibody, anti-ire1-alpha antibody, anti-ER to nucleus signalling 1 antibody, anti-inositol-requiring 1 antibody, anti-IRE1P antibody, anti-IRE1MGC163279 antibody, anti-MGC163277 antibody, anti-endoplasmic reticulum to nucleus signaling 1 antibody

IRE1 alpha [p Ser724] Antibody Summary:

Species:	Hu, Mu, Rt, Mk(-)	Gene:	ERN1
Applications:	WB	Purity:	Immunogen affinity purified
Clonality:	Polyclonal	Host:	Rabbit
Specificity:	IRE-1 alpha Phosphospecific [Ser724]
Publications:	NB100-2323 has been mentioned in at least 20 Publications

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IRE1 alpha [p Ser724] Antibody Details:

Immunogen:	A synthetic peptide surrounding the phosphorylated serine 724 of the human IRE1 alpha protein. [Swiss-Prot #O75460]
Localization:	Endoplasmic reticulum
Modification:	p Ser724

Species Reactivity:

Reacts with human, mouse, and rat. Does not react with monkey.

Applications:

Uses:	This antibody is useful for Western blot of the phosphorylated protein. The molecular weight of IRE-1 alpha is ~110 kD.
Dilutions:	Western Blot 1:1000
Unit Size:	0.1 ml (also available: 0.025 ml (sample size))
Concentration:	1.16 mg/ml
Positive Controls:	1 Positive Controls
Conjugated Antibodies:	5 Conjugated Antibodies

Packaging:

Storage:	Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
Buffer:	PBS containing 30% glycerol
Preservative:	0.1% Sodium Azide
Limitations:	This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.

Gene Symbol: ERN1

Entrez:	2081 (Human)
	78943 (Mouse)
	498013 (Rat)
Uniprot:	O75460 (Human)

Related Genes:

Background:

IRE1 acts as the sensor of unfolded proteins in the ER that initiates transmittance of the unfolded protein signal from the ER to the nucleus by splicing XBP1 mRNA converting it into a potent unfolded-protein response transcriptional activator. It is a transmembrane protein that has both serine-threonine kinase and endoribonuclease activities. Null mutants are viable, but IRE1 is essential for viability under stress conditions that cause unfolded proteins to accumulate in the ER.

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