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IQGAP1 Antibody (1260)

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Product Details

Summary
Product Discontinued
View other related IQGAP1 Primary Antibodies

Order Details


    • Catalog Number
      NB100-63052
    • Availability
      Product Discontinued

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IQGAP1 Antibody (1260) Summary

Immunogen
Fusion protein of a domain of murine mKIAA0051 (amino acid residues 1536-1675, MW 14 kDa) expressed in E. coli.
Specificity
NB100-63052 binds to the C-terminal 122 amino acids of mKIAA0051, also known as Murine IQ motif containing GTPase activating protein 1.The mKIAA0051 protein (IQGAP1) has a fundamental role in cell motility and invasion. It binds to activated CDC42 but does not stimulate its GTPase activity. It also associates with calmodulin and regulates cadherin-based cell adhesion. Potentially mKIAA0051 serves as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. NB100-63052 may bind to the human Ras GTPase-activating-like protein IQGAP1 (p195), due to 98% sequence identity in the antigen region.
Clonality
Monoclonal
Host
Human
Gene
IQGAP1
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • ELISA Immunohistochemistry-FrozenWestern Blot
  • Immunohistochemistry
  • Immunohistochemistry-Frozen
  • Western Blot

Reactivity Notes

Mouse. Not yet tested in other species.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
No buffer
Preservative
Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for IQGAP1 Antibody (1260)

  • HUMORFA01
  • IQ motif containing GTPase activating protein 1
  • IQGAP1
  • KIAA0051ras GTPase-activating-like protein IQGAP1
  • p195
  • p195RasGAP-like with IQ motifs
  • SAR1

Background

IQGAP1 encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol IQGAP1