IQGAP1 Antibody (NB100-63052)

IQGAP1 Antibody (1260)

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IQGAP1 Antibody (1260) Summary:
Species:Mu
Applications:ELISA, IHC-Fr, WB
Clonality:Monoclonal
Gene:IQGAP1
Purity:Affinity purified
Host:Human
Specificity:NB100-63052 binds to the C-terminal 122 amino acids of mKIAA0051, also known as Murine IQ motif containing GTPase activating protein 1.The mKIAA0051 protein (IQGAP1) has a fundamental role in cell motility and invasion. It binds to activated CDC42 but does not stimulate its GTPase activity. It also associates with calmodulin and regulates cadherin-based cell adhesion. Potentially mKIAA0051 serves as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. HCA008 may bind to the human Ras GTPase-activating-like protein IQGAP1 (p195), due to 98% sequence identity in the antigen region.
Publications:Antibody has at least 2 Background References.
Note: Not all species have been tested for usefulness with this product. Only those species listed have been tested. We cannot make any guarantees about additional reactivities which may or may not occur.
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IQGAP1 Antibody (1260) Details:
Clone:1260
Immunogen:Fusion protein of a domain of murine mKIAA0051 (amino acid residues 1536-1675, MW 14 kDa) expressed in E. coli.
Species Reactivity:

Mouse. Not yet tested in other species.

Applications:
Uses:This antibody is useful for ELISA, Immunohistochemistry-Frozen, Western Blot
Dilutions:ELISA Immunohistochemistry-Frozen Western Blot
Unit Size:0.1 mg
Concentration:Please see the vial label for concentration.
Packaging:
Storage:Store at 4 °C short term. Aliquot and store at -20 °C long term. Avoid freeze-thaw cycles.
Preservative:Sodium Azide
Limitations:This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.
Gene Symbol: IQGAP1
 
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Working with IQGAP1

IQGAP1 Antibody (1260) Images (2)
Western Blot: KIAA0051 Antibody (1260) [NB100-63052] - analysis of various adult mouse tissues showing a band at approx. 191kDa when probed with 0.5ug/ml NB100-63052 followed by Goat anti Human IgG F(ab')2: HRP Immunohistochemistry-Frozen: KIAA0051 Antibody (1260) [NB100-63052] - Staining of frozen sections from 10 week-old ICR mice stained with 2ug/ml KIAA0051
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Publications (2)

IQGAP1 Antibody (1260) Background References:

  1. Ohara, R. et al. (2006) Antibodies for proteomic research: comparison of traditional immunization with recombinant antibody technology. Proteomics. 6: 2638-2646.
  2. Mataraza, J. M. et al. (2003) IQGAP1 promotes cell motility invasion. J. Biol. Chem. 278: 41237-41245.

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Jump to: Peptides and Proteins, Primary Antibodies, RNAi, Secondary Antibodies

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IQGAP1 in Context


Research Areas related to IQGAP1 (1):
Novus Explorer for IQGAP1 gene

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