Recombinant Human IGFBP-1 Protein Summary
| Description |
IGFBP-1 (Human) Recombinant Protein
Source: Mouse
Amino Acid Sequence: |
Preparation Method |
Mammalian cell (NSO) expression system |
| Details of Functionality |
The ED50 as determined by its ability to inhibit IGF-I induced proliferation of NUC-1 cells is ~100 ng/mL. |
| Protein/Peptide Type |
Recombinant Protein |
| Gene |
IGFBP1 |
Applications/Dilutions
| Dilutions |
|
| Application Notes |
This product is useful for and SDS-PAGE and Functional assays. |
Reactivity Notes
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles. |
| Buffer |
Lyophilized from 10 mM HCl |
| Preservative |
No Preservative |
| Reconstitution Instructions |
Reconstitute with deionized water to desired concentration. |
Notes
This product is produced by and distributed for Abnova, a company based in Taiwan.
Alternate Names for Recombinant Human IGFBP-1 Protein
Background
IGFBP1 is a gene that codes for an IGF-binding protein that circulates in the plasma and prolongs the half-life of IGFs and works to either inhibit of stimulate the growth promoting effects while also promoting cell migration and has a length of 259 amino acids and a weight of approximately 28 kDa. Current studies are being done on several diseases and disorders relating to this gene including protein-energy malnutrition, pre-eclampsia, persistent fetal circulation syndrome, Silver-Russell syndrome, growth hormone deficiency, Ehlers-Danlos syndrome, glucose intolerance, Prader-Willi syndrome, and chronic fatigue syndrome. IGFBP1 has also been shown to have interactions with IGF1, IGF2, MMP26, TF, and ARNT in pathways such as the myometrial relaxation and contraction, HIF-1-alpha transcription factor, IGF regulation, and protein metabolism pathways.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are
guaranteed for 1 year from date of receipt.
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