Heme Oxygenase 1 Antibody (EP1391Y) (NB110-57028)

Heme Oxygenase 1 Antibody (EP1391Y) (NB110-57028) (0.1 ml)

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	Catalog Number	NB110-57028
	Size(s)	0.1 ml	Price:
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anti-HSP32 antibody, anti-HO1 antibody, anti-EC 1.14.99.3 antibody, anti-HO antibody, anti-bK286B10 antibody, anti-HO-1heme oxygenase 1 antibody, anti-heat shock protein, 32-kD antibody, anti-heme oxygenase (decycling) 1 antibody

Heme Oxygenase 1 Antibody (EP1391Y) Summary:

Species:	Hu, Mu, Rt(-)	Gene:	HMOX1
Applications:	WB, ICC, IHC-P, IP	Purity:	IgG purified
Clonality:	Monoclonal	Host:	Rabbit
Publications:	NB110-57028 has at least 3 Background References

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Heme Oxygenase 1 Antibody (EP1391Y) Details:

Clone:	EP1391Y
Isotype:	IgG
Immunogen:	A synthetic peptide corresponding to residues near the C-terminus of human HO-1 was used as an immunogen.
Localization:	Microsomal
Marker:	Endoplasmic Reticulum Marker

Species Reactivity:

Reacts in Human and Mouse. Does not react in Rat.

Applications:

Uses:	This product is useful for: Western Blot, Immunohistochemistry-Paraffin, Immunocytochemistry, Immunoprecipitation. In Western blot this antibody detects a band at approximately 32kDa.
Dilutions:	Western Blot 1:1000-10000, Immunohistochemistry-Paraffin 1:100-250, Immunocytochemistry 1:250-500, Immunoprecipitation 1:60
MW:	32 kDa
Unit Size:	0.1 ml
Concentration:	Please see the vial label for concentration.
Positive Controls:	1 Positive Controls

Packaging:

Storage:	Store at -20°C. Avoid freeze-thaw cycles.
Buffer:	50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA.
Preservative:	0.01% Sodium Azide
Limitations:	This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.

Gene Symbol: HMOX1

Entrez:	3162 (Human)
	15368 (Mouse)
	24451 (Rat)
Uniprot:	P09601 (Human)

Related Genes:

Background:

Stressed mammalian cells up-regulate heme oxygenase 1 (HO-1), which catabolizes heme to biliverdin, carbon monoxide, and free iron. Results provide genetic evidence that up-regulation of HO-1 serves as an adaptive mechanism to protect cells from oxidative damage during stress (1). When cells are injured they release their contents, resulting in a local accumulation of free heme proteins and heme. HO-1 plays a crucial role in the inflammatory process during wound healing (2). TNFalpha accelerates inflammatory responses by down-regulating HO-1 expression in human monocytes. TNF antagonists may block this TNF-dependent suppression of HO-1 expression, resulting in an amelioration of inflammation (3).

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Heme Oxygenase 1 Antibody (EP1391Y) Images (3)

	Western Blot: Heme Oxygenase 1 (HO-1) Antibody (EP1391Y) [NB110-57028] - Western blot analysis on fetal liver lysate using anti-HO-1 (cat. # 110-57028), dilution 1:2000

	Immunofluorescent: Heme Oxygenase 1 (HO-1) Antibody (EP1391Y) [NB110-57028] - Immunofluorescent staining of HeLa cells using anti-HO-1 (cat. #110-57028).

	Immunohistochemistry: Heme Oxygenase 1 (HO-1) Antibody (EP1391Y) [NB110-57028] - Immunohistochemical staining of paraffin-embedded human liver using anti-HO-1 (cat. #110-57028).