Heterochromatin protein 1 (HP1) is localized at heterochromatin sites, where it mediates gene silencing. A component of heterochromatin, HP1 recognizes and binds histone H3, leading to epigenetic repression. HP1 may interact with lamin B receptor (LBR), and this interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. The Drosophila HP1 protein, product of the Su(var)2-5 locus, is a dose dependent regulator of gene silencing. HP1 interacts with compacted chromatin (heterochromatin) via its chromodomain (CD). The HP1 protein is also known to interact with a number of transcriptional regulators via its chromoshadow (CSD) domain, suggesting that HP1 is a bridging factor that couples particular chromatin structures with effects on gene expression.
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FAQs for HP1 alpha (2)
In the immunohistochemistry paraffin section protocol....the PBS buffer....should it be at certain pH?
For IHC application, different labs cites the pH of PBS buffer in the range of 7.1 - 7.6 but most commonly used pH is pH 7.4 (this is what we use in our lab). You may use this PBS (pH 7.4) for making permeablization buffer, antibody diluent buffers and for making wash buffer. For more on the protocol that we use in our lab and for IHC-P troubleshooting suggestions, you may visit: IHC-P Protocol and IHC-P Troubleshooting.
I was wondering what does Format 7C mean as far as anitbodies go?
7C is a fluorophore - it is useful for FLOW. The details of the fluor are (A=425, E=500)