HP1 alpha Antibody (MAC385) 2 ml Heterochromatin Marker

HP1 alpha SM1543

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Ordering Information

Catalog Number  SM1543

Availability  Discontinued

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HP1 alpha Antibody (MAC385) Summary

 
Species Human, Mouse
Tested Applications WB, ELISA, IHC, IHC-Fr
Clonality Monoclonal
Host Rat
Gene CBX5
Purity Tissue culture supernatant
Specificity This recognizes the M32 molecule in mouse and the HP1 HS gamma molecule in man. MAC385 has also been reported for use in Western blotting and recognizes a 22kD protein in murine nuclear extracts. M32 has been shown to be distributed in a fine grain pattern within interphase nucleui.
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HP1 alpha Antibody (MAC385) Details

 
Clone MAC385
Isotype IgM
Marker Heterochromatin Marker
Immunogen Full length M32 fusion protein
Localization Nuclear

Species Reactivity

 
Human and mouse. Other species not tested.

Applications/Dilutions

 
Dilutions
  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
Application Notes

Immunohistochemistry of frozen sections. ELISA. Western blotting. Other applications not tested. Optimal dilutions of this antibody are dependent on conditions and should be determined by the user.

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Protocols and FAQs

Controls & Support Products

Research Tools

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Packaging, Storage & Formulations

 
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Unit Size 2 ml
Concentration This product is unpurified. The exact concentration of antibody is not quantifiable.
Preservative 0.09% Sodium Azide
Limitations This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

 
Gene Symbol CBX5
Entrez

Alternate Names for HP1 alpha

 
  • HP1 alpha
  • HP1A
  • HP1Hs alpha
  • Heterochromatin protein 1 homolog alpha
  • HP1 alpha homolog
  • Antigen p25
  • heterochromatin protein 1-alpha
  • chromobox homolog 5 (HP1 alpha homolog, Drosophila)
  • chromobox protein homolog 5
  • HP1-ALPHA
  • chromobox homolog 5 (Drosophila HP1 alpha)
  • HP1
  • HP1Hs-alpha
  • chromobox homolog 5

Related Products by Gene

Background

 
Heterochromatin protein 1 (HP1) is localized at heterochromatin sites, where it mediates gene silencing. A component of heterochromatin, HP1 recognizes and binds histone H3, leading to epigenetic repression. HP1 may interact with lamin B receptor (LBR), and this interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. The Drosophila HP1 protein, product of the Su(var)2-5 locus, is a dose dependent regulator of gene silencing. HP1 interacts with compacted chromatin (heterochromatin) via its chromodomain (CD). The HP1 protein is also known to interact with a number of transcriptional regulators via its chromoshadow (CSD) domain, suggesting that HP1 is a bridging factor that couples particular chromatin structures with effects on gene expression.