HP1 alpha Antibody (MAC385) 2 ml Heterochromatin Marker

HP1 alpha SM1543

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Ordering Information

Catalog Number  SM1543

Availability  Discontinued

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HP1 alpha Antibody (MAC385) Summary

Species Human, Mouse
Tested Applications WB, ELISA, IHC, IHC-Fr
Clonality Monoclonal
Host Rat
Gene CBX5
Purity Tissue culture supernatant
Specificity Please Note: Catalog Number SM1543 has been replaced with NBP2-34835. Please contact Novus Biologicals with questions.
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HP1 alpha Antibody (MAC385) Details

Clone MAC385
Isotype IgM
Marker Heterochromatin Marker
Immunogen Full length M32 fusion protein
Localization Nuclear

Species Reactivity

Human and mouse. Other species not tested.


  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
Application Notes

Immunohistochemistry of frozen sections. ELISA. Western blotting. Other applications not tested. Optimal dilutions of this antibody are dependent on conditions and should be determined by the user.

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Protocols and FAQs

Controls & Support Products

Research Tools

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Packaging, Storage & Formulations

Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Unit Size 2 ml
Concentration This product is unpurified. The exact concentration of antibody is not quantifiable.
Preservative 0.09% Sodium Azide
Limitations This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.


Gene Symbol CBX5

Alternate Names for HP1 alpha

  • HP1 alpha
  • HP1A
  • HP1Hs alpha
  • Heterochromatin protein 1 homolog alpha
  • HP1 alpha homolog
  • Antigen p25
  • heterochromatin protein 1-alpha
  • chromobox homolog 5 (HP1 alpha homolog, Drosophila)
  • chromobox protein homolog 5
  • chromobox homolog 5 (Drosophila HP1 alpha)
  • HP1
  • HP1Hs-alpha
  • chromobox homolog 5

Related Products by Gene


Heterochromatin protein 1 (HP1) is localized at heterochromatin sites, where it mediates gene silencing. A component of heterochromatin, HP1 recognizes and binds histone H3, leading to epigenetic repression. HP1 may interact with lamin B receptor (LBR), and this interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. The Drosophila HP1 protein, product of the Su(var)2-5 locus, is a dose dependent regulator of gene silencing. HP1 interacts with compacted chromatin (heterochromatin) via its chromodomain (CD). The HP1 protein is also known to interact with a number of transcriptional regulators via its chromoshadow (CSD) domain, suggesting that HP1 is a bridging factor that couples particular chromatin structures with effects on gene expression.