HOMER2 Antibody (NB100-98712)
HOMER2 Antibody
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anti-Home2 antibody, anti-HOMER-2 antibody, anti-Homer protein homolog 2 antibody, anti-Homer 2 antibody, anti-Home 2 antibody, anti-Cupidin antibody, |
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HOMER2 Antibody Summary: | | Gene: | HOMER2 |
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| Purity: | Whole antisera |
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| Host: | Rabbit |
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| | | Note: Not all species have been tested for usefulness with this product. Only those species listed have been tested. We cannot make any guarantees about additional reactivities which may or may not occur. |
View Additional HOMER2 Products HOMER2 Antibody Details: | Immunogen: | A synthetic peptide from the internal part of human HOMER2 conjugated to an immunogenic carrier protein was used as the immunogen. The immunogen is homologous with the corresponding sequence in mouse, rat, bovine. |
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| Uses: | Immunohistochemistry-Paraffin/Frozen and Western Blot. |
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| Dilutions: | Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Western Blot 1:300-1:2000 |
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| Unit Size: | 0.1 ml |
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| Concentration: | lyoph |
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| Positive Controls: | 1 Positive Controls |
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Packaging: | Storage: | Store at 4 °C short term. Aliquot and store at -20 °C long term. Avoid freeze-thaw cycles. |
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| Buffer: | Lyophilized Reconstitute in 0.1 ml of sterile water. Centrifuge to remove any insoluble material. When reconstituting, glycerol (1:1) may be added for an additional stability. |
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| Preservative: | No Preservative |
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| Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. |
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Background: FUNCTION: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with CENTG1. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. SUBUNIT: Isoform 1 and isoform 2 encode coiled-coil structures that mediate homo- and heteromultimerization. SUBCELLULAR LOCATION: Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Note: Postsynaptic density of neuronal cells. The stabilization and clustering of the metabotropic glutamate receptors appears to be mediated by isoform 1 and isoform 2 at the cell surface.
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Working with HOMER2
HOMER2 Antibody Images (0)
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Publications (6)HOMER2 Antibody Background References:- Rong R, et a. Nat. Neurosci. 6:1153-1161(2003).
- Kato A, et al. J. Biol. Chem. 273:23969-23975(1998).
more... - Barzik M, et al. J. Mol. Biol. 309:155-169(2001).
- Tu J.C, et al. Neuron 21:717-726(1998).
- Soloviev M, et al. J. Mol. Biol. 295:1185-1200(2000).
- Xiao B, et al. Neuron 21:707-716(1998).
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