HIF-1 alpha Antibody (H1alpha67) 0.1 ml

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Western Blot: HIF-1 alpha Antibody (H1alpha67) [NB100-105] - HIF-1 alpha induction by CoCl2 on Caki-1 cell lysate. Image from verified customer review.
Immunocytochemistry/Immunofluorescence: HIF-1 alpha Antibody (H1alpha67) [NB100-105] - Expression of HIF-1 in intresititial pig cells under 12% of 02 condition. Image from verified customer review.
Immunohistochemistry: HIF-1 alpha Antibody (H1alpha67) [NB100-105] - Staining of HIF1 alpha in human kidney. Renal tubular epithelium showed moderate membranous, cytoplasmic and nuclear staining, and glomeruli showed faint to moderate nuclear staining.
Flow Cytometry: HIF-1 alpha Antibody (H1alpha67) [NB100-105] - Analysis of HIF-1 alpha in multiple myeloma cells: H929 cells (0.5x10^6) were stained with HIF-1a antibody (NB100-105) conjugated with Alexa Fluor ® 488. Image courtesy of Dr. Barbara Muz at Washington University in St. Louis School of Medicine.
Western Blot: HIF-1 alpha Antibody (H1alpha67) [NB100-105] - Analysis of 50ug cobalt chloride (CoCl2) induced COS-7 nuclear extracts (NB800-PC26).
Tissue Culture Substratum: HIF-1 alpha Antibody (H1alpha67) [NB100-105] - analysis of HIF-1 alpha in human hepatocytes from cancer patient using anti-HIF-1 alpha antibody. Image from verified customer review.
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HIF-1 alpha Antibody (H1alpha67) Summary

Species Human, Mouse, Rat, Bovine, Ferret, Porcine, Primate, Rabbit, Sheep, Xenopus, Yeast
Tested Applications WB, ChIP, ELISA, Flow, GS, ICC/IF, IHC, IHC-Fr, IHC-P, IP
Protein G purified
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HIF-1 alpha Antibody (H1alpha67) Details

Fusion protein containing amino acids 432-528 of human HIF-1 alpha. [UniProt# Q16665]
HIF-1 is a nuclear protein.

Species Reactivity

Human, monkey, sheep, mouse, rat, rabbit, pig, bovine and ferret. Reactivity with Candida albicans reported by a customer review. Reactivity with Xenopus reported in the scientific literature (PMID: 18303027).
Publications Read Publications using NB100-105 in the following species:


  • Western Blot 1:500
  • Chromatin Immunoprecipitation 1:10-1:500
  • Flow Cytometry
  • Gel Super Shift Assays 1:1-1:100
  • Immunocytochemistry/Immunofluorescence 1:50
  • Immunohistochemistry 1:20-1:50
  • Immunohistochemistry-Frozen 1:20-1:50
  • Immunohistochemistry-Paraffin 1:20-1:50
  • Immunoprecipitation 1:10-1:500
Application Notes
This HIF-1 alpha (H1alpha67) antibody is useful for Chromatin Immunoprecipitation (PMID: 21871655), ELISA (PMID: 20042684), Flow Cytometry, Gel Super Shift Assays, Immunocytochemistry/Immunofluorescence, Immunohistochemistry on frozen and paraffin-embedded sections, Immunoprecipitation and Western Blot. In WB, a band can be seen at 120 kDa representing HIF-1 alpha in induced tissues and cells. Multiple bands may be seen at 100-120 kDa representing post-translational modification of HIF-1 alpha. For WB, testing on nuclear extracts is recommended. This antibody has been used to immunoprecipitate human HIF-1 alpha. For ChIP, refer to research papers with PubMed ID 16204079 and 21871655. This product has been cited for Gel Super Shift Assays in PubMed ID 22411794.
Molecular Weight
120 kDa
Positive Controls
Other Available
Alexa Fluor (R) 405 Labeled NB100-105AF405
Alexa Fluor (R) 488 Labeled NB100-105AF488
Alexa Fluor (R) 647 Labeled NB100-105AF647
Alexa Fluor (R) 700 Labeled NB100-105AF700
Biotin Labeled NB100-105B
DyLight 405 Labeled NB100-105V
DyLight 488 Labeled NB100-105G
DyLight 550 Labeled NB100-105R
DyLight 650 Labeled NB100-105C
FITC Labeled NB100-105F
HRP Labeled NB100-105H
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NB100-105 in the following applications:

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HIF-1 alpha Antibody (NB100-105) has been mentioned in at least 481 publications.
Earn rewards if you have published using HIF-1 alpha Antibody (NB100-105).


There are reports that this antibody does not detect mouse in IHC-paraffin embedded tissue. It does work to detect mouse protein in Western blot.

Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS with 1% BSA
Unit Size
0.1 ml
1.0 mg/ml
0.05% Sodium Azide
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.


Gene Symbol HIF1A

Alternate Names for HIF-1 alpha Antibody (H1alpha67)

  • ARNT-interacting protein
  • Basic-helix-loop-helix-PAS protein MOP1
  • BHLHE78
  • Class E basic helix-loop-helix protein 78
  • HIF-1-alpha
  • HIF1-alpha
  • hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcriptionfactor)
  • hypoxia-inducible factor 1-alpha
  • Member of PAS protein 1
  • member of PAS superfamily 1
  • PAS domain-containing protein 8
  • PASD8alpha subunit (basic helix-loop-helix transcriptionfactor)
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Related Products by Gene


HIF1 (hypoxia-inducible factor 1), a heterodimeric transcription factor complex central to cellular response to hypoxia, consists of two subunits (HIF-1 alpha and HIF-1 beta) which are basic helix-loop-helix proteins of the PAS (Per, ARNT, Sim) family. Expression of HIF-1 alpha protein is regulated by cellular oxygen level alterations as well as in oxygen-independent manner via different cytokines (through the PI3K-AKT-mTOR pathway), growth factors, oncogenic activation, or loss of tumor suppressor function etc. In normoxic cells, HIF-1 alpha is proline hydroxylated leading to a conformational change that promotes its binding to the VLH (von Hippel Lindau) protein E3 ligase complex; ubiquitination and followed by rapid proteasomal degradation. Hypoxia as well as chemical hydroxylase inhibitors (desferrioxamine, cobalt etc.) inhibit HIF-1 alpha degradation and lead to its accumulation in the cells, whereas, contrastingly, HIF-1 beta/ARNT (AhR nuclear translocator) remains stable under both conditions. Besides their critical role in hypoxic response, HIF1s regulates the transcription of genes responsible for angiogenesis, erythropoiesis/iron-metabolism, glucose metabolism, cell proliferation/survival, adipogenesis, carotid body formation, B lymphocyte development and immune reactions.

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Publications for HIF-1 alpha Antibody (NB100-105) (481)

Read what people are writing who have used HIF-1 alpha Antibody (NB100-105).

We have publications tested in 10 confirmed species: Human, Mouse, Rat, Bovine, Canine, Porcine, Primate, Rabbit, Sheep, Xenopus.

We have publications tested in 10 applications: WB, ChIP, ELISA, Flow, GS, ICC/IF, IHC, IHC-Fr, IHC-P, IP.

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Ryu J, Lee C-W, Hong K-H et al. Activation of fractalkine/CX3CR1 by vascular endothelial cells induces angiogenesis through VEGF-A/KDR reverses hindlimb ischaemia. Cardiovasc Res. May 1, 200878(2):333-40. [PMID: 18006432] (WB, Human) WB Human
Bohonowych JE, Peng S, Gopal U et al. Comparative analysis of novel and conventional Hsp90 inhibitors on HIF activity and angiogenic potential in clear cell renal cell carcinoma: implications for clinical evaluation. BMC Cancer;11(1):520. 2011 Dec 15. [PMID: 22172030] (WB, Human) WB Human
Duyndam, MC et al. Induction of vascular endothelial growth factor expression and hypoxia-inducible factor 1alpha protein by the oxidative stressor arsenite. J Biol Chem;276(51):48066-76. 2001 Dec 21. [PMID: 11641398] (WB, Human) WB Human
Alberghini A, Recalcati S, Tacchini L et al. Loss of the von Hippel Lindau tumor suppressor disrupts iron homeostasis in renal carcinoma cells. J Biol Chem. 280(34):30120-8. 2005 Aug 26. [PMID: 15985433] (WB, Human) WB Human
Liu W, Guo M, Xu YB et al. Induction of tumor arrest and differentiation with prolonged survival by intermittent hypoxia in a mouse model of acute myeloid leukemia. 107(2):698-707. 2006 Jan 15. [PMID: 16166593] (WB, Mouse) WB Mouse
Trentin, D et al. Peptide-matrix-mediated gene transfer of an oxygen-insensitive hypoxia-inducible factor-1alpha variant for local induction of angiogenesis. Proc Natl Acad Sci U S A. 103(8):2506-11. 2006 Feb 21. [PMID: 16477043] (WB, Human) WB Human
Hsu, T et al. Endocytic function of von Hippel-Lindau tumor suppressor protein regulates surface localization of fibroblast growth factor receptor 1 and cell motility. J Biol Chem. 281(17):12069-80. 2006 Apr 28. [PMID: 16505488] (WB, Human) WB Human
Bracken CP, Fedele AO, Linke S et al. Cell-specific regulation of hypoxia-inducible factor (HIF)-1alpha HIF-2alpha stabilization transactivation in a graded oxygen environment. J Biol Chem;281(32):22575-85. 2006 Aug 11. [PMID: 16760477] (WB, Human) WB Human
McMahon S, Charbonneau M, Grandmont S et al. Transforming growth factor beta1 induces hypoxia-inducible factor-1 stabilization through selective inhibition of PHD2 expression. J Biol Chem;281(34):24171-81. 2006 Aug 25. [PMID: 16815840] (WB, Human) WB Human
Chen, H et al. Hypoxic stress induces dimethylated histone H3 lysine 9 through histone methyltransferase G9a in mammalian cells. Cancer Res;66(18):9009-16. 2006 Sep 15. [PMID: 16982742] (WB, Human) WB Human
Lukashev D, Klebanov B, Kojima H et al. Cutting edge: hypoxia-inducible factor 1alpha and its activation-inducible short isoform I.1 negatively regulate functions of CD4+ and CD8+ T lymphocytes. J Immunol. 177(8):4962-5. 2006 Oct 15. [PMID: 17015677] (WB, Mouse) WB Mouse
Kang, S-H et al. Antitumor effect of 2-methoxyestradiol in a rat orthotopic brain tumor model. Cancer Res;66(24):11991-7. 2006 Dec 15. [PMID: 17178898] (IHC-P, Rat) IHC-P Rat
LaRusch GA, Jackson MW, Dunbar JD et al. Nutlin3 blocks vascular endothelial growth factor induction by preventing the interaction between hypoxia inducible factor 1alpha and Hdm2. Cancer Res;67(2):450-4. 2007 Jan 15. [PMID: 17234751] (IP, Human) IP Human
Liu, Y et al. Calcineurin promotes hypoxia-inducible factor 1alpha expression by dephosphorylating RACK1 and blocking RACK1 dimerization. J Biol Chem;282(51):37064-73. 2007 Dec 21. [PMID: 17965024] (WB, Human) WB Human
Zhang H, Bosch-Marce M, Shimoda LA et al. Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. J Biol Chem;283(16):10892-903. 2008 Apr 18. [PMID: 18281291] (WB, Mouse) WB Mouse
Moser C et al. ENMD-1198, a novel tubulin-binding agent reduces HIF-1alpha and STAT3 activity in human hepatocellular carcinoma(HCC) cells, and inhibits growth and vascularization in vivo. BMC Cancer;8:206. 2008 Jul 23. [PMID: 18651980] (WB, Human) WB Human
Zhang H, Qian DZ, Tan YS et al. Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth. Proc Natl Acad Sci U S A;105(50):19579-86. 2008 Dec 16. [PMID: 19020076] (WB, Human) WB Human
Wong W, Goehring AS, Kapiloff MS et al. mAKAP compartmentalizes oxygen-dependent control of HIF-1alpha. Sci Signal;1(51):ra18. 2008 Dec 23. [PMID: 19109240] (WB, IP, Human) IP, WB Human
Rezvani HR, Mahfouf W, Ali N, Chemin C et al. Hypoxia-inducible factor-1{alpha} regulates the expression of nucleotide excision repair proteins in keratinocytes. Nucleic Acids Res. 2009 Nov 24. [PMID: 19934262] (GS, ChIP, Human) ChIP, GS Human
Regazzetti C, Bost F, Le Marchand-Brustel Y et al. Insulin induces REDD1 expression through hypoxia-inducible factor 1 activation in adipocytes. J Biol Chem;285(8):5157-64. 2010 Feb 19. [PMID: 19996311] (WB, Mouse) WB Mouse
Tanaka T, Wakamatsu T, Daijo H et al. Persisting mild hypothermia suppresses hypoxia-inducible factor 1{alpha} protein synthesis and HIF-1-mediated gene expression. Am J Physiol Regul Integr Comp Physiol. 2009 Dec 30. [PMID: 20042684] (ELISA, Mouse) ELISA Mouse
Evens AM, Sehn LH, Farinha P et al. Hypoxia-inducible factor-1 {alpha} expression predicts superior survival in patients with diffuse large B-cell lymphoma treated with R-CHOP. J Clin Oncol;28(6):1017-24. 2010 Feb 20. [PMID: 20048181] (IHC, Human) IHC Human
Chen H, Kluz T, Zhang R, Costa M. Hypoxia and Nickel inhibit histone demethylase JMJD1A and repress Spry2 expression in human bronchial epithelial BEAS-2B cells. Carcinogenesis. 2010 Sep 29. [PMID: 20881000] (ChIP, Human) ChIP Human
Lunde IG, Anton SL, Bruusgaard JC, Rana ZA, Ellefsen S, Gundersen K. Hypoxia inducible factor 1 links fast-patterned muscle activity and fast muscle phenotype in rats. J Physiol;589(Pt 6):1443-54. 2011 Mar 15. [PMID: 21262877] (WB, Human, Rat) WB Human, Rat
Chaudhuri S, McCullough SS, Hennings L et al. Acetaminophen hepatotoxicity and HIF-1alpha induction in mice occurs without hypoxia. Toxicol Appl Pharmacol. 2011 Feb 10. [PMID: 21316383] (WB, Mouse) WB Mouse
Leh S, Hultstrom M, Rosenberger C, Iversen BM. Afferent arteriolopathy and glomerular collapse but not segmental sclerosis induce tubular atrophy in old spontaneously hypertensive rats. Virchows Arch. 2011 Jun 10. [PMID: 21660521] (IHC-P, Rat) IHC-P Rat
Nonoguchi N, Miyatake S-I, Fukumoto M et al. The distribution of vascular endothelial growth factor-producing cells in clinical radiation necrosis of the brain: pathological consideration of their potential roles. J Neurooncol. 2011 Jun 18. [PMID: 21688077] (IHC, Human) IHC Human
Yamada T, Uchida M, Kwang-Lee K, Kitamura N, Yoshimura T, Sasabe E, Yamamoto T. Correlation of metabolism/hypoxia markers and fluorodeoxyglucose uptake in oral squamous cell carcinomas. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 Jul 19. [PMID: 21778086] (IHC, Human) IHC Human
Kwon T-G, Zhao X, Yang Q et al. Physical and functional interactions between Runx2 and HIF-1[alpha] induce vascular endothelial growth factor gene expression. J Cell Biochem. 2011 Jul 25. [PMID: 21793044] (WB, IP, Mouse, Human) IP, WB Mouse, Human
Dang EV, Barbi J, Yang H-Y et al. Control of T(H)17/T(reg) Balance by Hypoxia-Inducible Factor 1. Cell. 2011 Aug 24. [PMID: 21871655]
Liu C, Tsai A-L, Chen Y-C et al. Facilitation of human osteoblast apoptosis by sulindac and indomethacin under hypoxic injury. J Cell Biochem. 2011 Aug 31. [PMID: 21882223] (WB, Human) WB Human
Ly A, Yee P, Vessey KA et al. Early inner retinal astrocyte dysfunction during diabetes and development of hypoxia, retinal stress and neuronal functional loss. Investigative Ophthalmology & Visual Science. 2011 Nov 22. [PMID: 22110070] (WB, Rat) WB Rat
Doe MR, Ascano J, Kaur M, Cole M. Myc post-transcriptionally induces HIF1 protein and target gene expression in normal and cancer cells. Cancer Research. 2011 Dec 20. [PMID: 22186139] (WB, Human) WB Human
Rezvani HR, Ali N, Serrano-Sanchez M et al. Loss of epidermal hypoxia-inducible factor-1[alpha] accelerates epidermal aging and affects re-epithelialization in human and mouse. Journal of Cell Science. 2011 Dec 22. [PMID: 22193962] (IHC-P, Mouse, Human) IHC-P Mouse, Human
Yang L, Fan M, Du F et al. The increased iron transport rate induced by hypoxic preconditioning in astrocytes. Biochimica Et Biophysica Acta. 2011 Dec 16. [PMID: 22198321] (WB, Rat) WB Rat
Shiau AL, Shen YT, Hsieh JL, Wu CL, Lee CH. Scutellaria barbata inhibits angiogenesis through downregulation of HIF-1 ? in lung tumor. Environ Toxicol doi: 10 1002/tox 21763. 2012 Feb 13. [PMID: 22331677] (WB, Human) WB Human
Hsieh YL, Chou LW, Chang PL, Yang CC, Kao MJ, Hong CZ. Low-level laser therapy alleviates neuropathic pain and promotes function recovery in rats with chronic constriction injury-possible involvements in hypoxia-inducible factor 1? (HIF-1?). J Comp Neurol. 2012 Feb 20. [PMID: 22351621] (WB, Rat) WB Rat
Yang L, Tan P, Zhou W, Zhu X, Cui Y, Zhu L, Feng X, Qi H, Zheng J, Gu P, Fan X, Chen H. N-Acetylcysteine Protects Against Hypoxia Mimetic-Induced Autophagy by Targeting the HIF-1? Pathway in Retinal Ganglion Cells. Cell Mol Neurobiol. 2012 May 23. [PMID: 22618532] (ICC/IF, Rat) ICC/IF Rat
Wang H, Chen Q, Lee SH, Choi Y, Johnson FB, Pignolo RJ. Impairment of Osteoblast Differentiation Due to Proliferation-independent Telomere Dysfunction in Mouse Models of Accelerated Aging. Aging Cell. 2012 May 23. [PMID: 22621437] (ICC/IF, Mouse) ICC/IF Mouse
Birner P, Schindl M, Obermair A et al. Overexpression of hypoxia-inducible factor 1alpha is a marker for an unfavorable prognosis in early-stage invasive cervical cancer. Cancer Res;60(17):4693-6. 2000 Sep 1. [PMID: 10987269] (IHC-P, Human) IHC-P Human
Birner P, Gatterbauer B, Oberhuber G et al. Expression of hypoxia-inducible factor-1 alpha in oligodendrogliomas: its impact on prognosis on neoangiogenesis. Cancer;92(1):165-71. 2001 Jul 1. [PMID: 11443623] (IHC-P, Human) IHC-P Human
Aminova LR, Chavez JC, Lee J et al. Prosurvival prodeath effects of hypoxia-inducible factor-1alpha stabilization in a murine hippocampal cell line. J Biol Chem. 280(5):3996-4003. 2005 Feb 4. [PMID: 15557337] (WB, Mouse) WB Mouse
Kong D, Park EJ, Stephen AG et al. Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity. Cancer Res. 65(19):9047-55. 2005 Oct 1. [PMID: 16204079] (EMSA, Human) Human
Franco, M et al. Targeted anti-vascular endothelial growth factor receptor-2 therapy leads to short-term and long-term impairment of vascular function and increase in tumor hypoxia. Cancer Res;66(7):3639-48. 2006 Apr 1. [PMID: 16585189] (WB, Human) WB Human
Nemetski SM, Gardner LB. Hypoxic regulation of Id-1 and activation of the unfolded protein response are aberrant in neuroblastoma. J Biol Chem;282(1):240-8. 2007 Jan 5. [PMID: 17102133] (WB, Mouse) WB Mouse
Rosenberger C, Rosen S, Shina A et al. Activation of hypoxia-inducible factors ameliorates hypoxic distal tubular injury in the isolated perfused rat kidney. Nephrol Dial Transplant(11):3472-8. 2008 Nov23. [PMID: 18515655] (IHC-P, Rat) IHC-P Rat
Nomura M, Ishii H, Kawakami A et al. Inhibition of Hepatic Neiman-Pick C1-Like 1 Improves Hepatic Insulin Resistance. Am J Physiol Endocrinol Metab. 2009 Aug 4. [PMID: 19654286]
Rey S, Lee K, Wang CJ et al. Synergistic effect of HIF-1alpha gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia. Proc Natl Acad Sci U S A;106(48):20399-404. 2009 Dec 1. [PMID: 19948968] (WB, Mouse) WB Mouse
Wen W, Ding J, Sun W et al. Suppression of cyclin D1 by hypoxia-inducible factor-1 via direct mechanism inhibits the proliferation and 5-fluorouracil-induced apoptosis of A549 cells. Cancer Res;70(5):2010-9. 2010 Mar 1. [PMID: 20179204] (IHC, Human) IHC Human
Jian J, Yang Q, Dai J et al. Effects of iron deficiency and iron overload on angiogenesis and oxidative stress-a potential dual role for iron in breast cancer. Free Radic Biol Med;50(7):841-7. 2011 Apr 1. [PMID: 21193031] (WB, Human) WB Human
Kummar S, Raffeld M, Juwara L et al. Multihistology, Target-Driven Pilot Trial of Oral Topotecan as an Inhibitor of Hypoxia-Inducible Factor-1{alpha} (HIF-1{alpha}) in Advanced Solid Tumors. Clin Cancer Res;17(15):5123-31. 2011 Aug 1. [PMID: 21673063] (IHC-P, Human) IHC-P Human
Hattori H, Okuda K, Murase T et al. Isolation, identification, and biological evaluation of HIF-1-modulating compounds from Brazilian green propolis. Bioorganic & Medicinal Chemistry. 2011 Aug 4. [PMID: 21865046] (WB, Human) WB Human
Han MW, Lee HJ, Cho KJ, Kim JS, Roh JL, Choi SH, Nam SY, Kim SY. Role of FDG-PET as a biological marker for predicting the hypoxic status of tongue cancer. Head Neck. 2011 Nov 3. [PMID: 22052623] (IHC, Human) IHC Human
Tang X, Lucas JE, Chen JL-Y et al. Functional interaction between responses to lactic acidosis and hypoxia regulates genomic transcriptional outputs. Cancer Research. 2011 Dec 1. [PMID: 22135092] (WB, Human) WB Human
Wang, B, Zou, Y, Li, H et al. Genistein Inhibited Retinal Neovascularization Expression of Vascular Endothelial Growth Factor Hypoxia Inducible Factor 1 alpha in a Mouse Model of Oxygen-Induced Retinopathy. J. of Ocular Pharmacology Therapeutics.:107-113. Apr. 2005. [PMID: 15857276] (Mouse) Mouse
Schrobback K, Malda J, Crawford R et al. Effects of Oxygen on Zonal Marker Expression in Human Articular Chondrocytes. Tissue Eng Part A;18(9-10):920-933. 2012 May. [PMID: 22097912] (IHC-Fr, ICC/IF, Human) ICC/IF, IHC-Fr Human
Palladino MA, Powell JD, Korah N et al. Expresion Localization of Hypoxia-Inducible Factor-1 Subunits in the Adult Rat Epididymis. Biol Reprod. 70(4):1121-30. 2004 Apr. [PMID: 1466820]
Lee KS, Kim SR, Park SJ et al. Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) reduces vascular endothelial growth factor expression in allergen-induced airway inflammation. Mol Pharmacol;69(6):1829-39. 2006 Jun. [PMID: 16527906] (WB, Mouse) WB Mouse
Nishimura, R et al. Oxygen concentration is an important factor for modulating progesterone synthesis in bovine corpus luteum. Endocrinology;147(9):4273-80. 2006 Sep. [PMID: 16740971] (WB, Bovine) WB Bovine
Bernhardt WM, Campean V, Kany S et al. Preconditional activation of hypoxia-inducible factors ameliorates ischemic acute renal failure. J Am Soc Nephrol;17(7):1970-8. 2006 Jul. [PMID: 16762988] (IHC-P, Rat) IHC-P Rat
Grimmer, C et al. Regulation of type II collagen synthesis during osteoarthritis by prolyl-4-hydroxylases: possible influence of low oxygen levels. Am J Pathol;169(2):491-502. 2006 Aug. [PMID: 16877351] (ICC/IF, Human) ICC/IF Human
Brooks C, Wang J, Yang T et al. Characterization of cell clones isolated from hypoxia-selected renal proximal tubular cells. Am J Physiol Renal Physiol. 2007 Jan. [PMID: 16885151] (WB, Human) WB Human
Lin AD, Mannikarottu A, Kogan BA et al. Estrogen induces angiogenesis of the female rabbit bladder. J Endocrinol. 190(2):241-6. 2006 Aug. [PMID: 16899558] (WB, Rabbit) WB Rabbit
Hwang II, Watson IR, Der SD, Ohh M. Loss of VHL confers hypoxia-inducible factor (HIF)-dependent resistance to vesicular stomatitis virus: role of HIF in antiviral response. J Virol;80(21):10712-23. 2006 Nov. [PMID: 16928739] (WB, IP, Human) IP, WB Human
McLaren AT, Marsden PA, Mazer CD et al. Increased expression of HIF-1alpha, nNOS, and VEGF in the cerebral cortex of anemic rats. Am J Physiol Regul Integr Comp Physiol;292(1):R403-14. 2007 Jan. [PMID: 16973934] (IHC-P, ICC/IF, Rat) ICC/IF, IHC-P Rat
Khan Z, Michalopoulos GK, Stolz DB. Peroxisomal localization of hypoxia-inducible factors and hypoxia-inducible factor regulatory hydroxylases in primary rat hepatocytes exposed to hypoxia-reoxygenation. Am J Pathol;169(4):1251-69. 2006 Oct. [PMID: 17003483] (IHC-P, Rat) IHC-P Rat
Biswas S, Gupta MK, Chattopadhyay D et al. Insulin-induced activation of hypoxia-inducible factor-1 requires generation of reactive oxygen species by NADPH oxidase. Am J Physiol Heart Circ Physiol;292(2):H758-66. 2007 Feb. [PMID: 17085541] (GS, Human) GS Human
Bernhardt WM, Wiesener MS, Weidemann A et al. Involvement of hypoxia-inducible transcription factors in polycystic kidney disease. Am J Pathol;170(3):830-42. 2007 Mar. [PMID: 17322369] (IHC-P, Rat) IHC-P Rat
Lang SA, Klein D, Moser C et al. Inhibition of heat shock protein 90 impairs epidermal growth factor-mediated signaling in gastric cancer cells and reduces tumor growth and vascularization in vivo. Mol Cancer Ther;6(3):1123-32. 2007 Mar. [PMID: 17363505] (WB, Human) WB Human
Bateman RM, Tokunaga C, Kareco T et al. Myocardial hypoxia-inducible HIF-1alpha, VEGF, and GLUT1 gene expression is associated with microvascular and ICAM-1 heterogeneity during endotoxemia. Am J Physiol Heart Circ Physiol;293(1):H448-56. 2007 Jul. [PMID: 17369472] (WB, Rat) WB Rat
Zhang H et al. HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity. Cancer Cell;11(5):407-20. 2007 May. [PMID: 17482131] (WB, Human) WB Human
Kimura K, Iwano M, Higgins DF et al. Stable expression of HIF-1alpha in tubular epithelial cells promotes interstitial fibrosis. Am J Physiol Renal Physiol;295(4):F1023-9. 2008 Oct. [PMID: 18667485] (IHC-P, Mouse) IHC-P Mouse
Trollmann R, Strasser K, Keller S et al. Placental HIFs as markers of cerebral hypoxic distress in fetal mice. Am J Physiol Regulatory Integrative Comp Physiol;295(6):R1973-81. 2008 Dec. [PMID: 18832080] (WB, IHC, Mouse) IHC, WB Mouse
Keely S, Glover LE, MacManus CF et al. Selective induction of integrin beta1 by hypoxia-inducible factor: implications for wound healing. FASEB J;23(5):1338-46. 2009 May. [PMID: 19103643] (ChIP, Human) ChIP Human
Hammerschmidt E, Loeffler I, Wolf G. Morg1 heterozygous mice are protected from acute renal ischemia-reperfusion injury. Am J Physiol Renal Physiol;297(5):F1273-87. 2009 Nov. [PMID: 19726548] (IHC, Mouse) IHC Mouse
Sims JR, Lee SW, Topalkara K et al. Sonic hedgehog regulates ischemia/hypoxia-induced neural progenitor proliferation. Stroke;40(11):3618-26. 2009 Nov. [PMID: 19762700] (WB, Mouse) WB Mouse
Hsieh CH, Kuo JW, Lee YJ et al. Construction of mutant TKGFP for real-time imaging of temporal dynamics of HIF-1 signal transduction activity mediated by hypoxia and reoxygenation in tumors in living mice. J Nucl Med;50(12):2049-57. 2009 Dec. [PMID: 19910419] (IHC, Mouse) IHC Mouse
Neusser MA, Lindenmeyer MT, Moll AG et al. Human nephrosclerosis triggers a hypoxia-related glomerulopathy. Am J Pathol;176(2):594-607. 2010 Feb. [PMID: 20019191] (IHC, WB, Human) IHC, WB Human
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Imamura Y, Tomita S, Imanishi M et al. HIF-2a/ARNT complex regulates hair development via induction of p21Waf1/Cip1 and p27Kip1. FASEB J. 3/5/2014 [PMID: 24599965] (WB, Mouse) WB Mouse
Shan F, Li J, Huang QY. HIF-1 Alpha-Induced Up-Regulation of miR-9 Contributes to Phenotypic Modulation in Pulmonary Artery Smooth Muscle Cells During Hypoxia. J. Cell. Physiol. 2/25/2014 [PMID: 24615545] (WB, Rat) WB Rat
Zhao L, Yang YF, Gao YB et al. Upregulation of HIF-1a Via Activation of ERK and PI3K Pathway Mediated Protective Response to Microwave-Induced Mitochondrial Injury in Neuron-Like Cells. Mol. Neurobiol. 3/14/2014 [PMID: 24627260] (WB, Rat) WB Rat
Pan WL, Wong JH, Fang EF et al. Preferential cytotoxicity of the type I ribosome inactivating protein alpha-momorcharin on human nasopharyngeal carcinoma cells under normoxia and hypoxia. Biochem. Pharmacol. 3/14/2014 [PMID: 24637239] (WB, Human) WB Human
Sano M, Sasaki T, Hirakawa S et al. Lymphangiogenesis and angiogenesis in abdominal aortic aneurysm. PLoS ONE 3/21/2014 [PMID: 24651519] (IHC-P, Human) IHC-P Human
Zhang WG, He L, Shi XM et al. Regulation of transplanted mesenchymal stem cells by the lung progenitor niche in rats with chronic obstructive pulmonary disease. Respir. Res. 3/25/2014 [PMID: 24661402] (IHC-P, WB, Rat) IHC-P, WB Rat
Raspaglio G, Petrillo M, Martinelli E et al. Sox9 and Hif-2a regulate TUBB3 gene expression and affect ovarian cancer aggressiveness. Gene 3/21/2014 [PMID: 24661907] (WB, Human) WB Human
Chang ML, Chiu CJ, Shang F, Taylor A. High Glucose Activates ChREBP-Mediated HIF-1a and VEGF Expression in Human RPE Cells Under Normoxia. Adv. Exp. Med. Biol. 3/25/2014 [PMID: 24664750] (WB, Human) WB Human
Zheng J, Song F, Lu SL, Wang XQ. Dynamic Hypoxia in Scar Tissue During Human Hypertrophic Scar Progression. Dermatol Surg 2014 Mar 31 [PMID: 24684437] (IHC-P, Human) IHC-P Human
Kim YS, Lee HA, Lim JY et al. beta-Carotene inhibits neuroblastoma cell invasion and metastasis in vitro and in vivo by decreasing level of hypoxia-inducible factor-1alpha. J. Nutr. Biochem. 2014 Mar 13 [PMID: 24746828] (WB, IHC-P, Human) IHC-P, WB Human
Xu W, Kwon JH, Moon YH et al. Influence of preoperative transcatheter arterial chemoembolization on gene expression in the HIF-1alpha pathway in patients with hepatocellular carcinoma. J. Cancer Res. Clin. Oncol. 2014 May 23 [PMID: 24853275] (IHC-P, Human) IHC-P Human
Arreola A, Cowey CL, Coloff JL et al. HIF1alpha and HIF2alpha Exert Distinct Nutrient Preferences in Renal Cells. PLoS ONE. 2014 Jun 02 [PMID: 24879016] (WB, Mouse) WB Mouse
Xiong Y, Qu Z, Chen N et al. The local corticotropin-releasing hormone receptor 2 signalling pathway partly mediates hypoxia-induced increases in lipolysis via the cAMP-protein kinase A signalling pathway in white adipose tissue. Mol. Cell. Endocrinol. 2014 May 22 [PMID: 24859650] (WB, Rat) WB Rat
Wu JB, Shao C, Li X et al. Near-infrared fluorescence imaging of cancer mediated by tumor hypoxia and HIF1alpha/OATPs signaling axis. Biomaterials. 2014 Jun 20 [PMID: 24957295] (IHC-P, Human)

Archival formalin-fixed paraffin-embedded/FFPE human prostate cancer/PCa specimens were processed for IHC staining with HIF1 alpha antibody (clone H1alpha67, 1:30 dilution).
IHC-P Human
Yang MY, Chiao MT, Lee HT et al. An innovative three-dimensional gelatin foam culture system for improved study of glioblastoma stem cell behavior J. Biomed. Mater. Res. Part B Appl. Biomater. 2014 Jun 26 [PMID: 24966152] (IHC, Human)

HIF-1 alpha antibody used for IHC -DAB of xenograft tissue of human glioblastoma stem cells/GSCs grown in gelatin foam. Figure 5 f - HIF1 alpha used as an intrinsic marker of tumor hypoxia.
IHC Human
Vorrink SU, Sarsour EH, Olivier AK et al. PCB 126 perturbs hypoxia-induced HIF-1a activity and glucose consumption in human HepG2 cells Exp. Toxicol. Pathol. 2014 Jun 07 [PMID: 24916446] (IHC-P, Rat)

HIF 1 alpha antibody used for FFPE liver sections from male Sprague-Dawley rats treated or not with PCB 126 (AhR agonist ) - HIER using citrate buffer pH 6.0, Peroxidase quenching with 3% H2O2 for 8 min, blocking with 5% horse serum, 1:50 primary - 2 h incubation at RT, detected via Mouse Envision HRP System Reagent -DAB method. Fig 1 - PCB 126 treated livers had mainly cytoplasmic/decreased nuclear staining compared to control rats.
Privat M, Radosevic-Robin N, Aubel C et al. BRCA1 Induces Major Energetic Metabolism Reprogramming in Breast Cancer Cells. PLoS ONE 2014 Jul 11 [PMID: 25010005] (WB, Human)

HIF-1 alpha antibody used for WB on hypoxia mimetic CoCl2 treated /not treated SUM1315-BRCA1 and SUM1315-LXSN cell lines which were obtained by stable transfection of SUM1315 human breast cancer cells with an empty LXSN plasmid, or a BRCA1-encoding LXSN plasmid (WB image shown in Figure S1).
WB Human
Kalamida D, Karagounis IV, Giatromanolaki A, Koukourakis MI. Important role of autophagy in endothelial cell response to ionizing radiation. PLoS ONE 2014 Jul 11 [PMID: 25010689] (WB, Human)

HIF-1 alpha antibody used for WB on lysates of HUVEC/human umbilical vein endothelial cells after exposure to 2 Gy of IR with or without 2 day pre-incubation with SMER28/Small-Molecule Enhancer of Rapamycin-28 (an mTOR-independent inducer of autophagy). Primary antibody was used at 1:500 dilution and the blot images are not shown in the article.
WB Human
Zhou W, Marinescu M, Veltkamp R. Only Very Early Oxygen Therapy Attenuates Posthemorrhagic Edema Formation and Blood-Brain Barrier Disruption in Murine Intracerebral Hemorrhage. Neurocrit Care 2014 Jul 15 [PMID: 25022804] (WB, Mouse)

HIF-1 alpha antibody used for WB (1:500 dilution) on lysates of serial coronal cryosections of hemorrhagic and nonhemorrhagic hemispheres from C57BL/6 male mice 3d after inducing Intracerebral Hemorrhage/ ICH (Fig 6B).
WB Mouse
Kasper LH, Qu C, Obenauer JC et al. Genome-wide and single-cell analyses reveal a context dependent relationship between CBP recruitment and gene expression. Nucleic Acids Res. 2014 Sep 23 [PMID: 25249627] (ChIP, Mouse) ChIP Mouse
Vorrink SU. Regulatory crosstalk and interference between the PCB 126 stimulated AHR and hypoxia stimulated HIF-1a signaling pathways. 2014 (IHC-P, Rat)

Mouse monoclonal anti-HIF-1 alpha antibody used for IHC on paraffin-embedded livers from untreated and PCB 126 treated rats at a dilution of 1:50, incubated for 2 hours at room temperature (Figure 3-1)
Gu J, Fan Y, Liu X et al. SENP1 protects against myocardial ischaemia/reperfusion injury via a HIF1a-dependent pathway. Cardiovasc. Res. 2014 Jul 31 [PMID: 25082844] (WB, IP, Rat) IP, WB Rat
Huang T, Huang W, Zhang Z et al. Hypoxia-inducible factor-1a upregulation in microglia following hypoxia protects against ischemia-induced cerebral infarction. Neuroreport. 2014 Oct 01 [PMID: 25089804]
Lee HS, Kim KS, Lim HS et al. Priming Wharton's jelly-derived mesenchymal stromal/stem cells with ROCK inhibitor improves recovery in an intracerebral hemorrhage model. J Cell. Biochem. 2014 Sep 04 [PMID: 25185536]
Shinohara M, Kibi M, Riley IR et al. Cell-Cell Interactions and Bronchoconstrictor Eicosanoid Reduction With Inhaled Carbon Monoxide and Resolvin D1. Am. J. Physiol. Lung Cell Mol. Physiol. 2014 Sep 12 [PMID: 25217660] (ICC/IF, Human) ICC/IF Human
Samanta D, Gilkes D, Chaturvedi P, Xiang L, Semenza G. Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells. Proc Natl Acad Sci U S A. 2014 Dec 1 [PMID: 25453096] (WB, Human) WB Human
Bordji K, Grandval A, Cuhna-Alves L et al. Hypoxia-inducible factor-2a (HIF-2a), but not HIF-1a, is essential for hypoxic induction of class III b-tubulin expression in human glioblastoma cells. FEBS J. 2014 Sep 22 [PMID: 25244496] (WB, GS, Human)

HIF-1 alpha antibody used for WB and EMSA/Gel Super Shift Assay in experiments involving human glioblastoma cell lines - U87MG (p53 wild-type, PTEN mutant) , U251MG (p53 mutant, PTEN mutant) and GL15 (obtained from a frontal lobe tumor biopsy of a 59-year-old man with GBM).
GS, WB Human
Funk K, Scheerer N, Verhaegh R et al. Severe blunt muscle trauma in rats: only marginal hypoxia in the injured area PLoS OnE et al. 2014 Nov 01 [PMID: 25360779] (IHC-P, Rat)

HIF1 alpha antibody used for IHC-P on right Musculus gastrocnemius tissue section of male Wistar rats subjected to severe blunt muscle trauma with standardized weight-drop device - paraformaldehyde-fixed-paraffin-embedded sections, primary antibody dilution of 1:10000, catalyzed signal amplification system from DAKO, staining development with DAB-Hematoxylin (Figure 5).
Assar Me, Sanchez-Puelles Jm, Royo I et al. FM19G11 reverses endothelial dysfunction in rat and human arteries through stimulation of the PI3K/Akt/enOS pathway, independently of mTOR/HIF-1Alpha activation Br. J. Pharmacol. 2014 Nov 03 [PMID: 25363469] (WB, Rat)

HIF-1 alpha antibody used for WB on lysates of ex vivo FM19G11 treated aortic and mesenteric arteries from control and insulin-resistant rats (Figure 6).
WB Rat
Rahman Su, Lee Ms, Baek Jh et al. The Prolyl Hydroxylase Inhibitor Dimethyloxalylglycine Enhances Dentin Sialophoshoprotein Expression through VEGF-Induced Runx2 Stabilization PLoS OnE et al. 2014 Nov 05 [PMID: 25369078] (WB, Rat)

HIF1 alpha antibody used for WB on the whole cell lysates of MDPC-23 cells (a rat odontoblast-like cell line) incubated for 24 h in the presence or absence of DMOG 0-1 mM concentration (Figure 1B).
WB Rat
Yoshikawa N, Shimizu N, Ojima H et al. Down-regulation of hypoxia-inducible factor-1 alpha and vascular endothelial growth factor by HEXIM1 attenuates myocardial angiogenesis in hypoxic mice. Biochem. Biophys. Res. Commun. 2014 Oct 06 [PMID: 25301555] (WB, Human) WB Human
Marhold M, Tomasich E, El-Gazzar A et al. HIF-1alpha Regulates mTOR Signaling and Viability of Prostate Cancer Stem Cells. Mol. Cancer Res. 2014 Oct 27 [PMID: 25349289] (WB, IP, Human, Mouse) IP, WB Human, Mouse
Sato Y, Miyauchi Y, Yoshida S et al. The Vitamin D Analogue ED71 but not 1,25(OH)2D3 Targets HIF1Alpha Protein in Osteoclasts PLoS OnE et al. 2014 Nov 07 [PMID: 25375896] (WB, Mouse) WB Mouse
Wu X, He L, Chen F et al. Impaired autophagy contributes to adverse cardiac remodeling in acute myocardial infarction. PLoS OnE. 2014 Nov 21 [PMID: 25409294] (WB, Mouse) WB Mouse
Gillespie DL, Aguirre MT, Ravichandran S et al. RNA interference targeting hypoxia-inducible factor 1alpha via a novel multifunctional surfactant attenuates glioma growth in an intracranial mouse model. J. Neurosurg. 2014 Nov 25 [PMID: 25423275] (IHC-P, Human)

HIF1 alpha antibody used for IHC-P on sections of orthotopic mouse model with U87-LucNeo cells subjected to RNAi mediated knock down HIF-1 alpha in vivo
IHC-P Human
Jeong S, Park H, Hong S et al. Lipophilic modification enhances anti-colitic properties of rosmarinic acid by potentiating its HIF-prolyl hydroxylases inhibitory activity. Eur. J. Pharmacol. 2014 Dec 04 [PMID: 25483211] (WB, Human)

HIF1 alpha antibody used for WB in experiments involving human colon carcinoma HCT116 and HT29 cells, human renal cancer UMRC2 cells and UMRC2/VHL cells (stably transfected with VHL)
WB Human
Rutz S, Kayagaki N, Phung QT et al. Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells. Nature. 2014 Dec 03 [PMID: 25470037] (WB, Mouse)

HIF1 alpha antibody used for WB on lysates of Duba+/+ and Duba-/- mouse CD4+ T(H)17 cells stimulated with anti-CD3 and anti-CD28 antibodies in the presence of TGF-b and IL-6 (Figure 7).
WB Mouse
Hung YH, Chang SH, Huang CT et al. Inhibitor of Differentiation-1 and Hypoxia-Inducible Factor-1 Mediate Sonic Hedgehog Induction by Amyloid Beta-Peptide in Rat Cortical Neurons. Mol. Neurobiol. 2014 Dec 15 [PMID: 25502463] (ChIP, Rat) ChIP Rat
Queisser MA, Dada LA, Deiss-Yehiely N. HOIL-1L Functions as the PKC-zeta Ubiquitin Ligase to Promote Lung Tumor Growth. Am. J. Respir. Crit. Care Med. 2014 Aug 13 [PMID: 25118570]
Brandes F, Schmidt K, Wagner C, Redekopf J. Targeting cMET with INC280 impairs tumour growth and improves efficacy of gemcitabine in a pancreatic cancer model BMC Cancer. 2015 (WB, Human)

HIF-1 alpha antibody used for WB application on lysates of human pancreatic cancer cell line MiaPaCa2 treated or not with cMET inhibitor / ATP-competitive inhibitor INC280 (also known as INCB028060) and/or hypoxia-mimicking agent deferroxaminemesylate (Figure 2-I).
WB Human
Hasan AU, Ohmori K, Konishi K et al. Eicosapentaenoic acid upregulates VEGF-A through both GPR120 and PPARgamma mediated pathways in 3T3-L1 adipocytes Mol. Cell. Endocrinol. 2015 Feb 16 [PMID: 25697344] (WB, Mouse) WB Mouse
Li R, Wang Y, Yang Z et al. Hypoxia-inducible factor-1alpha regulates the expression of L-type voltage-dependent Ca(2+) channels in PC12 cells under hypoxia Cell Stress Chaperones. 2015 Feb 04 [PMID: 25648081] (WB, Rat) WB Rat
Srivastava S, Thakkar B, Yeoh KG et al. Expression of proteins associated with hypoxia and Wnt pathway activation is of prognostic significance in hepatocellular carcinoma Virchows Arch. 2015 Mar 06 [PMID: 25742908] (IHC-P, Human) IHC-P Human
Fillmore N, Huqi A, Jaswal JS et al. Effect of Fatty acids on human bone marrow mesenchymal stem cell energy metabolism and survival. PLoS ONE. 2015 Mar 15 [PMID: 25768019] (WB, Human) WB Human
Wang F, Zhang G, Xing T et al. Renalase contributes to the renal protection of delayed ischaemic preconditioning via the regulation of hypoxia-inducible factor-1a. J. Cell. Mol. Med. 2015 Mar 17 [PMID: 25781495] (WB, Human) WB Human
Paeng SH, Jung WK, Park WS et al. Caffeic acid phenethyl ester reduces the secretion of vascular endothelial growth factor through the inhibition of the ROS, PI3K and HIF-1 alpha signaling pathways in human retinal pigment epithelial cells under hypoxic conditions Int. J. Mol. Med. 2015 May 01 [PMID: 25738890] (WB, Human) WB Human
Schiffer Davide, Mellai Marta, Annovazzi Laura et al. Stem cell niches in glioblastoma: a neuropathological view. Biomed Res Int. 2014 Apr 15 [PMID: 24834433] (Human) Human
Wang Wen-Sheng, Liang Hong-Yin, Cai Yu-Jiao, Yang Hua. DMOG ameliorates IFN-gamma-induced intestinal barrier dysfunction by suppressing PHD2-dependent HIF-1alpha degradation. J Interferon Cytokine Res. 2014 Jan 01 [PMID: 24010824] (Human) Human
Huang Miaoling, Chen Qing, Xiao Jianpeng et al. Overexpression of hypoxia-inducible factor-1alpha is a predictor of poor prognosis in cervical cancer: a clinicopathologic study and a meta-analysis. Int J Gynecol Cancer. 2014 Jul 01 [PMID: 24978711] (Human) Human
Bohuslavova Romana, Kolar Frantisek, Sedmera David et al. Partial deficiency of HIF-1alpha stimulates pathological cardiac changes in streptozotocin-induced diabetic mice. BMC Endocr Disord. 2014 Feb 06 [PMID: 24502509] (WB, Mouse) WB Mouse
He YL, Li MM, Wu LY et al. Enhanced Hypoxia-Inducible Factor (HIF)-1 alpha Stability Induced by 5-Hydroxymethyl-2-Furfural (5-HMF) Contributes to Protection against Hypoxia Mol. Med. 2015 Mar 27 [PMID: 25333920] (WB, ICC/IF, Mouse, Rat) ICC/IF, WB Mouse, Rat
Gauter-Fleckenstein Benjamin, Reboucas Julio S, Fleckenstein Katharina et al. Robust rat pulmonary radioprotection by a lipophilic Mn N-alkylpyridylporphyrin, MnTnHex-2-PyP(5+). Redox Biol. 2014 Jan 09 [PMID: 24624330] (IHC, Rat) IHC Rat
Salman Shaima, Holloway Alison C, Nurse Colin A. Chronic opioids regulate KATP channel subunit Kir6.2 and carbonic anhydrase I and II expression in rat adrenal chromaffin cells via HIF-2alpha and protein kinase A. Am J Physiol Cell Physiol. 2014 Aug 01 [PMID: 24898587] (Rat) Rat
Przybyla Beata D, Shafirstein Gal, Vishal Sagar J et al. Molecular changes in bone marrow, tumor and serum after conductive ablation of murine 4T1 breast carcinoma. Int J Oncol. 2014 Feb 01 [PMID: 24270800] (WB) WB
Narise Kosuke, Okuda Kensuke, Enomoto Yukihiro et al. Optimization of biguanide derivatives as selective antitumor agents blocking adaptive stress responses in the tumor microenvironment. Drug Des Devel Ther. 2014 Jun 06 [PMID: 24944508] (WB) WB
Zhang Xiaonan, Fryknas Marten, Hernlund Emma et al. Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments. Nat Commun. 2014 [PMID: 24548894]
Yang Xi, Zhu Hongcheng, Ge Yangyang et al. Melittin enhances radiosensitivity of hypoxic head and neck squamous cell carcinoma by suppressing HIF-1alpha. Tumour Biol. 2014 Jul 23 [PMID: 25053591]
Chen Jing, Li Tao, Liu Qilun et al. Clinical and prognostic significance of HIF-1alpha, PTEN, CD44v6, and survivin for gastric cancer: a meta-analysis. PLoS One. 2014 Mar 19 [PMID: 24647137]

Product General Protocols

View specific protocols for HIF-1 alpha Antibody (NB100-105): Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

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FAQs for HIF-1 alpha (18)

  1. Which antibody(ies) do you recommend for the detection of HIF-1a by immunohistochemistry in the sections of paraffin-embedded mouse liver samples? I would appreciate if you can give me several choices and rank them in the order of performance. My goal is to distinguish HIF upregulation by prolyl hydroxylase inhibitor in different liver cells.
    • All of our antibodies are of high quality and are well tested/validated in species/applications we list on the datasheet. However, as desired by you, I am suggesting you four HIF-1 alpha antibodies based upon customer reviews, as well as the number of peer reviewed publications in which these products has been cited by researchers from reputed institutes. (1) HIF-1 alpha Antibody (H1alpha67) (cat# NB100-105) (cited in at least 218 peer reviewed publications) (2) HIF-1 alpha Antibody (cat# NB100-479) (cited in at least 51 peer reviewed publications) (3) HIF-1 alpha Antibody (H1alpha67) (cat# NB100-123 ) (cited in at least 38 peer reviewed publications) (4) HIF-1 alpha Antibody (cat# NB100-449 ) (cited in at least 31 peer reviewed publications).
  2. What is the molecular weight (kDa) of protein HIF 1 alpha in western blot?
    • The theoretical molecular weight of HIF 1-alpha is ~93kDa, however, you will likely see a band between 100-120kDa due to phosphorylation.
  3. Why is there a difference between the theoretical MW for HIF1A and the observed MW for HIF-1 alpha?
    • HIF1A, like many other proteins, has post-translational modifications. Depending on the size, amount and nature of the post-translational modifications, it can cause subtle to very large changes in molecular weight.
  4. I would like to know, does it exist path for detection HIF 1 in the venous blood before and after revascularization of the leg?
    • We are not entirely sure if HIF-1 alpha will be present in the leg after revascularization. It may be present but you may want to search the literature to see if this has been looked at before. If not, then this would certainly be an experiment worth doing.
  5. Do you have any suggested IHC Protocol for this antibody? We had been trying to validate protocols from other reserach studies, but failed to get good results. Background staining seems to be the problem.
    • Yes, we have a specific IHC protocol for NB100-105. It is located on the datasheet under the "Protocols & FAQs" tab. We also have over 300 publications that utilize this product. If you need help finding a specific paper or if you would like us to help troubleshoot your experiment, please contact Technical Support at technical@novusbio.com.
  6. Has anyone used this antibody for supershft in EMSA?
    • Yes, this antibody is useful for EMSA and has been documented in couple of recent research publications. You may refer to the following paper for details: Kong D, et al. Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity. Cancer Res. 2005 Oct 1;65(19):9047-55 [PMID: 16204079].
  7. What is the difference in the following two HIF-1 alpha antibodies? Catalog # NB100-105 and NB100-134
    • NB100-105 is a mouse monoclonal antibody, whereas NB100-134 is a rabbit polyclonal. They both use the same immunogen.
  8. I am working on a WB using the antibody against mouse HIF1a and HIF2a (catalog numbers NB100-105 and NB100-122). I tried several anti-mouse and anti-rabbit HRP secondary antibodies (from another company) and found they gave different patterns. Please provide the secondary antibody info which was used in the WB showed on the datasheet.
    • We use catalog numbers NB7570 and NB7183 as our secondary antibodies for testing these antibodies in WB.
  9. What is the difference between NB100-105 and NB100-123?
    • NB100-105 and NB100-123 are similar as far as immunogens and clones are concerned, however, they are different with respect to their purification process, concentrations and recommended dilutions. NB100-123 is Protein A purified IgG2b with a concentration of 1.5 mg/ml, whereas NB100-105 is Protein G purified IgG2b with 4.0 mg/ml concentration. Another difference is the recommended dilutions (because of the differences in their concentration).
  10. Can I get a sample of the HIF1A antibody (NB100-105)?
    • We do offer this antibody is a Sample Size, which contains 0.025ml of antibody. The sample size catalog number is NB100-105SS.
  11. Does NB100-105 work well after stored in -20 degrees Celsius for two days? I forget to read the datasheet and put it in -20 when I got it.
    • In our experience with this product, freezing can damage the function of the antibody. Since it was only frozen for two days, your product might be fine. However, you may want to test it in a preliminary assay to be sure it is still functioning.
  12. I did staining of 150uM Cobalt chloride induced 3T12 for 24 hours using this HIF1alpha antibody. I used a 1:50 dilution for one hour at room temperature. Should I do an overnight incubation?
    • We do recommend incubating samples overnight at 4 degrees Celsius for the best results.
  13. Is there a product available to be used as the blocking peptide of NB100-105?
    • We unfortunately do not have a blocking peptide for NB100-105. It was raised against a fusion protein. We also unfortunately do not sell the protein.
  14. Could you, advice if I can use NBP1-96969 Ab as a control Ab for HIF1a for ChIP asay. I have a problem that normal rabbit IgG that usually are provided in the ChIP kits show higher binding compare to NB100-105 HIF1A Ab. Could you suggest if it is better to use Mouse IgG 2b Isotype control in this case or normal rabbit IgG should work as well? NBP1-96969 Ab are not validated for ChIP, please, let me know if there is something better?
    • Yes, it would be reasonable to use a mouse IgG2b control for NB100-105 (HIF1 alpha) in ChIP assay. The control provided in the ChIP kit is recommended as a control for the histone antibodies (which are rabbit polyclonal). NBP1-96969 would be a good choice for control for the mouse monoclonal NB100-105. It has not yet been validated for ChIP, but it has been validated for use in IP, so I think it will be a good choice for control.
  15. Hi, hope everthing goes well with you Here a customer intends to buy our HIF-1 alpha Antibody (H1alpha67), the link is <a href=http://www.novusbio.com/HIF-1-alpha-Antibody-H1alpha67_NB100-105.html>http://www.novusbio.com/HIF-1-alpha-Antibody-H1alpha67_NB100-105.html</a>.Since HIF-1 is nuclear protein, he wonders why there is obvious stainning in the cytoplasm, which is displayed in the IHC image on the product website. Can you so kind to help him and me?
    • HIF1-alpha is found at very low levels in the cytoplasm under normoxic conditions. During hypoxia, HIF1-alpha is stabilized and translocates to the nucleus to act as a transcription factor. You would therefore expect to see nuclear staining in your hypoxic samples, but may also observe faint cytoplasmic staining in relation to degraded HIF in the samples. As you know the HIF proteins are notoriously difficult to work with as they degrade very rapidly. The cytoplasmic staining is a result of HIF1-alpha degradation. I hope that this helps. if your customer has any further questions they may find our guide to working with hypoxia antibodies to be useful.
  16. I would like to know why I have to dilute 1:500 the primary antibody. How can I know which is the best dilution (or what amount of antibody I need to take) to my sample in the WB?
    • Our recommended dilution for use of NB100-105 in western blot is 1:500. You may need to adjust this dilution depending on the signal you are able to detect in your samples. I would recommend using a titer with 1:500 as the starting point to find the optimal dilution to use in your experiment.
  17. In the immunohistochemistry paraffin section protocol....the PBS buffer....should it be at certain pH?
    • For IHC application, different labs cites the pH of PBS buffer in the range of 7.1 - 7.6 but most commonly used pH is pH 7.4 (this is what we use in our lab). You may use this PBS (pH 7.4) for making permeablization buffer, antibody diluent buffers and for making wash buffer. For more on the protocol that we use in our lab and for IHC-P troubleshooting suggestions, you may visit: IHC-P Protocol and IHC-P Troubleshooting.
  18. I was wondering what does Format 7C mean as far as anitbodies go?
    • 7C is a fluorophore - it is useful for FLOW. The details of the fluor are (A=425, E=500)

Bioinformatics Tool for HIF-1 alpha

Discover related pathways, diseases and genes to HIF-1 alpha. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Bioinformatics Tool

Blogs on HIF-1 alpha

Check out the latest blog posts on HIF-1 alpha.
HIF-1 beta: A dimerization partner of HIF-1 alpha required for an adaptive response to hypoxia
Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease. Hypoxia-indu...  Read full blog post.

HIF-1 Alpha: Infographic
Encoded by the HIF1A gene, HIF-1 alpha has a critical role in cellular response to hypoxia. In hypoxic conditions, HIF-1 alpha activates the transcription of several genes to facilitate metabolic reaction for lack of oxygen. In normoxic conditions, HI...  Read full blog post.

Controlling the HIF-1 Switch
Hypoxia-inducible factor-1 is a major transcription factor composed of two subunits: HIF-1alpha and HIF-1 beta. Under normoxic conditions, HIF-1 alpha is targeted to proteosomal degradation via ubiquitination. On the other hand during hypoxic conditio...  Read full blog post.

Hypoxia Inducible Factor-1 beta and Cancer Development
Hypoxia inducible factor-1 (HIF-1) is a major transcription factor that is composed of two subunits: HIF-1 alpha and HIF-1 beta, the latter being a constitutively-expressed aryl hydrocarbon receptor nuclear transporter (ARNT). Under normoxic condition...  Read full blog post.

HIF Prolyl Hydroxylase 2: an important Oxygen Sensor Protein
Prolyl hydroxylase domain (PHD) proteins, including PHD1, PHD2, and PHD3, mediate oxygen-dependent degradation of hypoxia-inducible factor (HIF) alpha subunits. Suppression of PHD enzymes leads to stabilization of HIFs and offers a potential treatment...  Read full blog post.

Myc-tag: The "Monkey Wrench" of Proteomic Tools
c-Myc is a well-characterized transcription factor encoded by the c-Myc gene on human chromosome 8q24. This cellular proto-oncogene, also known as p62, is commonly activated in a variety of tumor cells and plays a crucial role in cellular proliferatio...  Read full blog post.

MAT2a, MAT2b, HIF-1 alpha: Roles in Liver Cancer and DNA methylation
Methionine Adenosyltransferase II alpha, also known as MAT2a, is a catalytic subunit of methionine adenosyltransferase (MAT) and essential enzyme for the catalysis of the principle biological methyl donor, S-adenosylmethionine (SAM) from methionine an...  Read full blog post.

Heat Shock Proteins: An Overview
Heat Shock Proteins (HSPs) are a ubiquitous group of molecular chaperone proteins that have evolved unique mechanisms, within their host cells, to facilitate survival in hostile environments such as heat, oxidative (hypoxia), pH and cold. Under permis...  Read full blog post.

Carbonic Anhydrase IX and Hypoxic Response: A Path to Tumors
Carbonic Anhydrase IX (CA-IX) is an enzyme that is induced under hypoxic conditions. This enzyme is rarely present in normal cells and is responsible for controlling tumor pH. CA-IX is a transmembrane glycoprotein of the zinc metalloenzyme family. Thi...  Read full blog post.

HIF-2 alpha Antibody Throws New Light on EPO Dilemma
The HIF family are heterodimeric, oxygen-sensitive transcription factors comprising an alpha and beta subunit which are normally dissociated in normoxic conditions. Our antibody catalog contains products targeting all the Hypoxia Inducible Factor isof...  Read full blog post.

HIF Antibodies: Beyond HIF-1 alpha
The hypoxia inducible factors are a family of heterodimeric transcription factors which are activated in response to lowered oxygen levels, or hypoxia. Although it may seem that HIF-1 alpha receives all the attention, other HIF antibodies, such as the...  Read full blog post.

A Role for HIF-1 alpha Antibody in Renal Research
The Hypoxia Inducible Factors (HIFs) are a family of mammalian transcription factors which are expressed in response to low cellular oxygen concentrations (hypoxia). Three human hypoxia inducible factors have been identified, HIF-1, HIF-2 and HIF-3, e...  Read full blog post.

Hypoxia-Inducible Factors and Homeostasis
Hypoxia-Inducible Factor-1 (HIF-1) is a highly conserved heterodimeric transcription factor. Novus' antibody catalogue contains an extensive range of both HIF-1 alpha and HIF-1 beta, useful for hypoxia, angiogenesis, cancer and many other areas of res...  Read full blog post.

We Heart HIF: HIF-1 Improves Angiogenesis Therapy in Ischemic Heart Tissue
Ischemic cardiovascular disease is the leading cause of death for both men and women in the US and most other industrialized countries. Most commonly caused by atherosclerosis of the coronary arteries, ischemic cardiovascular disease is characterized ...  Read full blog post.

Using the Hif-1 Alpha Antibody in Prostate Cancer Research
The Hypoxia-inducible Factor 1 (HIF1) protein is a heterodimeric transcription factor which plays an important role in mammalian oxygen homeostasis in conditions of hypoxia, or low oxygen concentration. HIF-1 alpha antibody reagents are widely used in...  Read full blog post.

HIF-1 Beta Antibody Studies and Developments in Hypoxia Research
We at Novus Biologicals have a large HIF-1 (Hypoxia Inducible Factor-1) antibody catalog, with twenty HIF-1 beta antibody products specifically targeted to the beta subunit of HIF-1, a heterodimer which is known to contribute to many human diseases ar...  Read full blog post.

The Role of LC3 within the Autophagic Pathway
We at Novus Biologicals have a broad antibody databasecovering the area of autophagy - over 1400 reagents in total. Autophagy is bulk degradation of cytoplasmic components - literally, self-digestion of the cell. Double-membrane vesicles, called autop...  Read full blog post.

The Link Between Base Excision Repair and Cancer Antibodies
Base excision repair (BER) is the most fundamental DNA repair mechanism, dealing with alterations arising in individual DNA bases during cellular metabolism. We at Novus Biologicals have a large BER antibody database, which has proven important in var...  Read full blog post.