Factor I Antibody

Catalog#:	H00003426-B01	This product is fully covered under guarantee+

Storage:	Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer:	This antibody is in antisera and the concentration is unavailable.
Preservative:	No Preservative

Purity:	Whole antisera
Host:	Mu
Clonality:	Polyclonal
Specificity:	IF - I factor (complement),
Modification:	No
Immunogen:	IF (-, 1 a.a. ~ 377 a.a) full-length human protein.
Epitope:	MKLLHVFLLFLCFHLRFCKVTYTSQE DLVEKKCLAKKYTHLSCDKVFCQPWQ RCIEGTCVCKLPYQCPKNGTAVCATN RRSFPTYCQQKSLECLHPGTKFLNNG TCTAEGKFSVSLKHGNTDSEGIVEVK LVDQDKTMFICKSSWSMREANVACLD LGFQQGADTQRRFKLSDLSINSTECL HVHCRGLETSLAECTFTKRRTMGYQD FADVVCYTQKADSPMDDFFQCVNGKY ISQMKACDGINDCGDQSDELC

Entrez:	3426 (Human)
Related Genes:	3426
Swiss Prot:	AAH20718.1 (Human)

This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uraemic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immmune deposits is another condition associated with mutation of this gene.

	Hu
reactivity:	Human..

	ELISA, WB
Uses:	Antibody reactive against Tissue Lysate and Transfected Lysate on Western Blot. It has also been used for ELISA.
Dilutions:	Western Blot 1:500, ELISA

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This product is produced by and distributed for Abnova, a company based in Taiwan.