G protein alpha Antibody

Species: Mk Applications: IHC-P, ELISA Clonality: Polyclonal	Gene: GNAS Purity: Protein G purified Host: Rabbit
Specificity: Amino acids 385 to 394 of human GNAS
See All G protein alpha Products See All G protein alpha Related Products: Lysates Peptides and Proteins Primary Antibodies RNAi
*Note not all species have been tested for reactivity. Only those species listed have been tested. We cannot make any guarantees about additional reactivities or cross reactivities beyond those that have been tested. This antibody may or may not react with other species.

Immunogen:	Synthetic peptide - KLH conjugated corresponding to Amino acids 385 to 394 of human GNAS

Entrez:	2778 (Human)
Swiss Prot:	Q5JWF2 (Human)
Related Genes:	PTH, GLUL, APC, PTRH1, ALB, EPO, ASAH1, INS, FXYD6, GH, RACGAP1, SOX3, SERPINI1, SPINK5, GNL3, CD55, STX16, HRAS1, NESPAS, KRAS, GCG, MAS1, AGT, MAPK1, GH1, NOTO, AVP, TRY5, CAT, F2, CDKN1A, GGH, NPPA, PRKAR1A, IAPP, SST, ATP8A2, GHRH, FOS, EPX

The GNAS1 gene encodes the alpha subunit of the G protein Gs, which couples receptor binding by several hormones to activation of adenylate cyclase (Hayward et al., 1998).This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contains a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript exists, and this antisense transcript and one of the transcripts are paternally expressed, produce noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.

Reactivity:	This antibody is reactive to Primate.

Uses:	This antibody is useful for the following applications and at the following dilutions: ELISA 1:0-1:1000, Immunohistochemistry-Paraffin 20 ug/ml
Dilutions:	ELISA 1:0-1:1000, Immunohistochemistry-Paraffin 20 ug/ml,
Concentrations:	1.0 mg/ml

Buffer:	Phosphate buffered saline
Storage:	Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Preservative:	0.1% Sodium Azide
Limitations:	This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.