Fas Antibody (DX2)

Species: Hu Applications: In vitro, IHC-Fr, IP, FACS Clonality: Monoclonal	Gene: FAS Purity: IgG purified Host: Mouse
Specificity: Human CD95/Fas/Apo-1 Publications: Antibody has not yet been mentioned in a publication.
See All Fas Products See All Fas Related Products: Antibody Pairs Kits Lysates Peptides and Proteins Primary Antibodies RNAi
*Note not all species have been tested for reactivity. Only those species listed have been tested. We cannot make any guarantees about additional reactivities or cross reactivities beyond those that have been tested. This antibody may or may not react with other species.

Clone:	DX2
Isotype:	IgG1
Immunogen:	Human CD95/Fas/Apo-1

Related Genes:	FASL, FASLG, TNF, CASP8, CASP3, BCL2, FASN, TNFSF10, BCL2L1, CASP9, TP53, TRP53, IL2, CTLA4, BAX, NKX3-1, CD4, HLA-DQA1, NOD2, LRP6, FADD, CD8A, IFNG, CFLAR, CDKN1A, TNFRSF1A, BID, CYCS, IL6, IL4, NFKB1, CD40, PARP1, ANXA5, IL10, SREBF1, AKT1, CASP1, CD40LG, TNFRSF10B

CD95, also known as Fas and Apo-1, is a 40-50 kDa type I transmembrane glycoprotein and a member of the tumor necrosis factor receptor superfamily. It is expressed by activated lymphocytes, monocytes, neutrophils, fibroblasts and cell lines. Fas ligand binding to CD95 induces apoptosis in activated mature lymphocytes thereby playing a role in maintaining peripheral tolerance. Crosslinking of CD95 by the monoclonal antibodies DX2 and DX3 delivers an apoptotic signal to Fas-sensitive cells, indicating that these monoclonal antibodies recognize a functional epitope of CD95. (1-5)

Reactivity:	Human.

Uses:	Flow cytometry / FACS analysis, Immunoprecipitation, Immunohistochemistry-Frozen and In vitro assay
Dilutions:	flow cytometry / FACS analysis ≤ 1 ug/1^6 cells, immunoprecipitation , Immunohistochemistry-Frozen , In vitro assay

Inquire about low endotoxin/azide-free CD95 antibody.

Buffer:	1.0 mL of 100 mM borate buffered saline, pH 8.2
Storage:	Store at 4C. Do not freeze.
Preservative:	No Preservative
Limitations:	This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.