Fas Antibody (DX2) (NBP1-28532)

Fas Antibody (DX2) (NBP1-28532) ( 0.1 mg)

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	Catalog Number	NBP1-28532
	Size(s)	0.1 mg	Price:
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anti-CD95 antigen antibody, anti-tumor necrosis factor receptor superfamily member 6 antibody, anti-FAS1 antibody, anti-Fas antigen antibody, anti-Apoptosis-mediating surface antigen FAS antibody, anti-Fas AMA antibody, anti-Apo-1 antigen antibody, anti-apoptosis antigen 1 antibody, anti-TNFRSF6member 6 antibody, anti-APT1FASTM antibody, anti-CD95ALPS1A antibody, anti-FASLG receptor antibody, anti-Fas (TNF receptor superfamily, member 6) antibody

Fas Antibody (DX2) Summary:

Species:	Hu	Gene:	FAS
Applications:	FACS, IHC-Fr, In vitro, IP	Purity:	IgG purified
Clonality:	Monoclonal	Host:	Mouse
Specificity:	Human CD95/Fas/Apo-1
Publications:	NBP1-28532 has at least 5 Background References

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Fas Antibody (DX2) Details:

Clone:	DX2
Isotype:	IgG1
Immunogen:	Human CD95/Fas/Apo-1

Species Reactivity:

Human.

Applications:

Uses:	Flow Cytometry, Immunoprecipitation, Immunohistochemistry-Frozen and In vitro assay
Dilutions:	Flow Cytometry < or =1 ug/10^6 cells, Immunohistochemistry-Frozen, Immunoprecipitation, In vitro assay
Unit Size:	0.1 mg
Concentration:	Please see the vial label for concentration.

Notes:

Inquire about low endotoxin/azide-free CD95 antibody.

Packaging:

Storage:	Store at 4°C. Do not freeze.
Buffer:	1.0 mL of 100 mM borate buffered saline, pH 8.2
Preservative:	No Preservative
Limitations:	This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.

Gene Symbol: FAS

Related Genes:

Background:

CD95, also known as Fas and Apo-1, is a 40-50 kDa type I transmembrane glycoprotein and a member of the tumor necrosis factor receptor superfamily. It is expressed by activated lymphocytes, monocytes, neutrophils, fibroblasts and cell lines. Fas ligand binding to CD95 induces apoptosis in activated mature lymphocytes thereby playing a role in maintaining peripheral tolerance. Crosslinking of CD95 by the monoclonal antibodies DX2 and DX3 delivers an apoptotic signal to Fas-sensitive cells, indicating that these monoclonal antibodies recognize a functional epitope of CD95. (1-5)

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Fas Antibody (DX2) Images (1)

	Flow cytometry / FACS analysis: Fas Antibody (DX2) [NBP1-28532] - The Jurkat human lymphoma cell line was stained with mouse anti-human CD95/Fas-FITC, following which large cells were gated and analyzed on a FACScan™ flow cytometer (BDIS, San Jose, CA).

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Publications (5)

Fas Antibody (DX2) Background References:

van Parijs, L., A.K. Abbas. 1996. Curr. Opin. Immunol. 8:355.
Nagata, S., P. Golstein. 1995. Science 267:3378.

more...

Barclay, A.N., M.H. Brown, S.K.A. Law, A.J. McKnight, M.G. Tomlinson, P.A. van der Merwe, eds. 1997. The Leukocyte Antigens Facts Book, 2nd Edition, CD95 Section, Academic Press, New York, p. 363.
Kishimoto, T., A.E.G. von dern Borne, S.M. Goyert, D.Y. Mason, M. Miyasaka, L. Moretta, K. Okumura, S. Shaw, T.A. Springer, K. Sugamura, H. Zola, eds. 1998. Leukocyte Typing VI: White Cell Differentiation Antigens, Academic Press, New York.
Schlossman, S., L. Bloumsell, W. Gilks, J.M. Harlan, C. Kishimoto, J. Ritz, S. Shaw, R. Silverstein, T. Springer, T.F. Tedder, R.F. Todd, eds. 1995. Leukocyte Typing V: White Cell Differentiation Antigens, Oxford University Press, Oxford.